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学科主题: 药学
题名:
Cholesteryl hemisuccinate as a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing saikosaponin-d
作者: Ding, WX; Qi, XR; Li, P; Maitani, Y; Nagai, T
关键词: cholesteryl hemisuccinate ; saikosaponin-d ; saponin ; liposome ; differential scanning calorimetry ; Fourier transform infrared spectroscopy
刊名: INTERNATIONAL JOURNAL OF PHARMACEUTICS
发表日期: 2005-08-26
DOI: 10.1016/j.ijpharm.2005.05.005
卷: 300, 期:1-2, 页:38-47
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: DIFFERENTIAL SCANNING CALORIMETRY ; RATS ; PROTECTION ; TOCOPHEROL
英文摘要:

In the present study, cholesteryl hemisuccinate (CHEMS) was evaluated for use as a membrane stabilizer in dipalmitoylphos-phatidylcholine (DPPC) liposomes. Differential scanning calorimetry (DSC) and a calcein release study showed that CHEMS was more effective than cholesterol (CHOL) in increasing DPPC membrane stability. The findings of Fourier transform infrared spectroscopy (FT-IR) also suggested that CHEMS interacts with DPPC via both hydrogen bonding and electrostatic interaction. More importantly, CHEMS did not interact with saikosaponin-d (SSD), a triterpene saponin from Bupleurum species, unlike CHOL. SSD-containing liposomes with DPPC, CHEMS and DSPE-PEG could greatly decrease the hemolytic activity of SSD. This study demonstrated that CHEMS has more stabilization ability than CHOL since CHEMS may exhibit both hydrogen bond interaction and electrostatic interaction with DPPC membrane while CHOL only has hydrogen bond interaction, resulting in stable and low-hemolytic SSD-liposomes. (c) 2005 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000231530200007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58039
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Hoshi Univ, Inst Med Chem, Shinagawa Ku, Tokyo 1428501, Japan
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China
3.China Japan Friendship Hosp, Dept Mat Med & Pharmacol, Beijing 100029, Peoples R China

Recommended Citation:
Ding, WX,Qi, XR,Li, P,et al. Cholesteryl hemisuccinate as a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing saikosaponin-d[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2005,300(1-2):38-47.
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