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学科主题: 基础医学
题名:
beta-Catenin/TCF/LEF1 can directly regulate phenylephrine-induced cell hypertrophy and Anf transcription in cardiomyocytes
作者: Zhang, Chen-Guang; Jia, Zhu-Qing; Li, Bin-Hong; Zhang, Hui; Liu, Yi-Nan; Chen, Ping; Ma, Kang-Tao; Zhou, Chun-Yan
关键词: beta-Catenin/TCF/LEF1 ; Cardiomyocyte hypertrophy ; Anf
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2009-12-11
DOI: 10.1016/j.bbrc.2009.09.101
卷: 390, 期:2, 页:258-262
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: INDUCED CARDIAC-HYPERTROPHY ; ATRIAL-NATRIURETIC-FACTOR ; BETA-CATENIN ; DOWN-REGULATION ; PATHWAY ; EXPRESSION ; GENE ; IDENTIFICATION ; MYOCYTES ; PROTEIN
英文摘要:

beta-Catenin/TCF/LEF1 signaling is implicated in cardiac hypertrophy. We demonstrate that knockdown of beta-catenin attenuates phenylephrine (PE)-induced cardiomyocyte hypertrophy and the up-regulation of the fetal gene Anf. We explore the mechanism through which p-catenin regulates Anf expression and find a consensus binding sequence on the Anf promoter for TCF/LEF1 family members. LEF1 binds directly to the Anf promoter via this sequence, which shows functional significance, and PE Stimulation enhances recruitment of beta-catenin onto the Anf promoter. Thus, we document a direct positive role of beta-catenin on PE-induced cardiomyocyte hypertrophy and identify a new target gene for beta-catenin/TCF/LEF1. (C) 2009 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 30871253 ; 90919022 ; 1307001
项目资助者: National Natural Sciences Foundation of China ; Ministry of Education of China
WOS记录号: WOS:000271552400016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58040
Appears in Collections:基础医学院_期刊论文

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作者单位: Peking Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Chen-Guang,Jia, Zhu-Qing,Li, Bin-Hong,et al. beta-Catenin/TCF/LEF1 can directly regulate phenylephrine-induced cell hypertrophy and Anf transcription in cardiomyocytes[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,390(2):258-262.
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