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学科主题基础医学
beta-Catenin/TCF/LEF1 can directly regulate phenylephrine-induced cell hypertrophy and Anf transcription in cardiomyocytes
Zhang, Chen-Guang; Jia, Zhu-Qing; Li, Bin-Hong; Zhang, Hui; Liu, Yi-Nan; Chen, Ping; Ma, Kang-Tao; Zhou, Chun-Yan
关键词Beta-catenin/tcf/lef1 Cardiomyocyte Hypertrophy Anf
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2009-12-11
DOI10.1016/j.bbrc.2009.09.101
390期:2页:258-262
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]INDUCED CARDIAC-HYPERTROPHY ; ATRIAL-NATRIURETIC-FACTOR ; BETA-CATENIN ; DOWN-REGULATION ; PATHWAY ; EXPRESSION ; GENE ; IDENTIFICATION ; MYOCYTES ; PROTEIN
英文摘要

beta-Catenin/TCF/LEF1 signaling is implicated in cardiac hypertrophy. We demonstrate that knockdown of beta-catenin attenuates phenylephrine (PE)-induced cardiomyocyte hypertrophy and the up-regulation of the fetal gene Anf. We explore the mechanism through which p-catenin regulates Anf expression and find a consensus binding sequence on the Anf promoter for TCF/LEF1 family members. LEF1 binds directly to the Anf promoter via this sequence, which shows functional significance, and PE Stimulation enhances recruitment of beta-catenin onto the Anf promoter. Thus, we document a direct positive role of beta-catenin on PE-induced cardiomyocyte hypertrophy and identify a new target gene for beta-catenin/TCF/LEF1. (C) 2009 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000271552400016
项目编号30871253 ; 90919022 ; 1307001
资助机构National Natural Sciences Foundation of China ; Ministry of Education of China
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58040
专题北京大学基础医学院
北京大学药学院_药学院
作者单位Peking Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100191, Peoples R China
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GB/T 7714
Zhang, Chen-Guang,Jia, Zhu-Qing,Li, Bin-Hong,et al. beta-Catenin/TCF/LEF1 can directly regulate phenylephrine-induced cell hypertrophy and Anf transcription in cardiomyocytes[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,390(2):258-262.
APA Zhang, Chen-Guang.,Jia, Zhu-Qing.,Li, Bin-Hong.,Zhang, Hui.,Liu, Yi-Nan.,...&Zhou, Chun-Yan.(2009).beta-Catenin/TCF/LEF1 can directly regulate phenylephrine-induced cell hypertrophy and Anf transcription in cardiomyocytes.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,390(2),258-262.
MLA Zhang, Chen-Guang,et al."beta-Catenin/TCF/LEF1 can directly regulate phenylephrine-induced cell hypertrophy and Anf transcription in cardiomyocytes".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 390.2(2009):258-262.
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