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学科主题药学
Preactivation: An Alternative Strategy in Stereoselective Glycosylation and Oligosaccharide Synthesis
Yang, Lin; Qin, Qi; Ye, Xin-Shan
关键词Carbohydrates Glycosylation Oligosaccharide Synthesis Preactivation Stereoselectivity
刊名ASIAN JOURNAL OF ORGANIC CHEMISTRY
2013
DOI10.1002/ajoc.201200136
2期:1页:30-49
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]4,6-O-BENZYLIDENE-DIRECTED BETA-MANNOPYRANOSYLATION ; NEIGHBORING-GROUP PARTICIPATION ; DIRECT CHEMICAL-SYNTHESIS ; ONE-POT SYNTHESIS ; ANTIGEN GLOBO-H ; ALPHA-SELECTIVE GLYCOSYLATIONS ; HEPARAN-SULFATE PROTEOGLYCANS ; GLYCOSIDE-BOND FORMATION ; PRE-ACTIVATION PROTOCOL ; 1,2-CIS O-GLYCOSYLATION
英文摘要

The multifaceted biological importance of carbohydrates has made them very popular targets in modern synthetic chemistry. Great progress has been made in stereoselective glycosylation methods and the construction of complex oligosaccharides. This Focus Review highlights the versatile applications of preactivation strategies in stereoselective glycosylation and oligosaccharide synthesis. Recent advances in synthetic methods, such as 4,6-O-benzylidene-acetal-directed beta-mannosylation, the 1,2-cis-glycosylation mediated by a chiral auxiliary, the use of an oxazolidinone or carbonate protecting group, and glycosylation with participating additives, are described. Various examples of sequential glycosylation based on preactivation protocols for efficient oligosaccharide assembly are also summarized.

语种英语
WOS记录号WOS:000325949000002
项目编号2012ZX09502001-001 ; 2012CB822100
资助机构Ministry of Science and Technology of China
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58042
专题北京大学药学院
北京大学药学院_药物化学系
北京大学第二临床医学院_图书馆
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
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GB/T 7714
Yang, Lin,Qin, Qi,Ye, Xin-Shan. Preactivation: An Alternative Strategy in Stereoselective Glycosylation and Oligosaccharide Synthesis[J]. ASIAN JOURNAL OF ORGANIC CHEMISTRY,2013,2(1):30-49.
APA Yang, Lin,Qin, Qi,&Ye, Xin-Shan.(2013).Preactivation: An Alternative Strategy in Stereoselective Glycosylation and Oligosaccharide Synthesis.ASIAN JOURNAL OF ORGANIC CHEMISTRY,2(1),30-49.
MLA Yang, Lin,et al."Preactivation: An Alternative Strategy in Stereoselective Glycosylation and Oligosaccharide Synthesis".ASIAN JOURNAL OF ORGANIC CHEMISTRY 2.1(2013):30-49.
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