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学科主题: 临床医学
题名:
Identification and function of coactivator of estrogen receptor: ERIAP
作者: Meng, QH; Zhou, LX; Cao, JP; Gao, B; Shao, RG; Li, JY; Fan, SJ
关键词: estrogen receptor ; breast cancer ; new gene ; ERIAP
刊名: SCIENCE IN CHINA SERIES C-LIFE SCIENCES
发表日期: 2003-10-01
DOI: 10.1360/03yc0062
卷: 46, 期:5, 页:546-558
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biology
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics
关键词[WOS]: STEROID-HORMONE RECEPTORS ; NUCLEAR RECEPTOR ; TRANSCRIPTIONAL ACTIVATION ; BRCA1 INHIBITION ; BREAST-CANCER ; ER-ALPHA ; BINDING ; LXXLL ; BETA ; RECRUITMENT
英文摘要:

Estrogen receptor (ER), one member of nuclear hormone receptor (NR) family, is an estrogen-dependent transcriptional factor that plays an important role in development, progression and treatment of breast cancer. Transcriptional co-factors (co-activators and co-repressors) are critical for ER to transduce hormone and metabolic signaling to target genes. A number of functional and structural studies have elucidated the precise mechanisms of co-activator interaction with the ligand-inducible activation domain in ER via one and several MILL motifs (where X is any amino acid) known as NR-Box. By the yeast two-hybrid system we have identified a novel ER-a interacting protein ERIAP (Estrogen Receptor Interacting and Activating Protein) which contains two consensus MILL motifs. ERIAP associated with ER-a in a ligand-dependent manner, as demonstrated by in vivo immunoprecipitation and in vitro GST capture assays. The two NR boxes were essential for ERIAP interaction with ER-a. Furthermore, ERIAP specifically enhanced ligand-mediated ER-a transcriptional activity in a dose-dependent fasion and increased the expression of estrogen-responsive gene pS2. Thus, our present findings indicate that ERIAP funcions as a new coactivator for ER-a transcriptional activity, which may play an important role in development and progression of breast cancer.

语种: 英语
WOS记录号: WOS:000185764100011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58043
Appears in Collections:北京大学临床肿瘤学院_病理科_期刊论文

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作者单位: 1.N Shore Long Isl Jewish Res Inst, Mol Oncol Lab, Manhasset, NY 11030 USA
2.Peking Univ, Beijing Canc Hosp, Dept Pathol, Beijing 100036, Peoples R China
3.Suzhou Univ, Sch Radiol & Publ Hlth, Suzhou 215007, Peoples R China
4.NIAAA, Div Liver Biol, NIH, Rockville, MD 20852 USA
5.Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China

Recommended Citation:
Meng, QH,Zhou, LX,Cao, JP,et al. Identification and function of coactivator of estrogen receptor: ERIAP[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,2003,46(5):546-558.
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