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学科主题: 精神卫生
题名:
Remission Rate and Functional Outcomes During a 6-Month Treatment With Osmotic-Release Oral-System Methylphenidate in Children With Attention-Deficit/Hyperactivity Disorder
作者: Su, Yi1; Li, Haibo2; Chen, Yixin3; Fang, Fang4; Xu, Tong5; Lu, Haiping6; Xie, Ling7; Zhuo, Jianmin8; Qu, Jiazhi8; Yang, Li1; Wang, Yufeng1
关键词: attention-deficit ; hyperactivity disorder ; executive ; methylphenidate ; remission ; social
刊名: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
发表日期: 2015-10-01
DOI: 10.1097/JCP.0000000000000389
卷: 35, 期:5, 页:525-534
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: DEFICIT-HYPERACTIVITY DISORDER ; QUALITY-OF-LIFE ; OROS METHYLPHENIDATE ; ADHD ; SYMPTOMS ; PREVALENCE ; IMPACT ; ADOLESCENTS ; ADULTS ; GOAL
英文摘要:

Many definitions have been used to evaluate remission in patients with attention-deficit/hyperactivity disorder (ADHD) in different studies resulting with varied remission rates. This open-label, multicenter study investigated the remission rate in Chinese children (n = 239; aged 6-16 years) with a diagnosis of ADHD (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition), treated with osmotic-release oral-system methylphenidate at doses of 18, 36, and 54 mg, once daily. Two definitions of remission were used: (1) (primary end point): average scores of SNAP-IV (Swanson, Nolan, and Pelham, Fourth Edition) items of 1 or less (0-3 rating scale for each item) according to the subtype of ADHD (inattentive [1-9], hyperactive-impulsive [10-18], and combined type [1-18]), and (2) total score of SNAP-IV items 1 to 18 of 18 or less, at week 8. The study consisted of screening/baseline, titration/open-label treatment (8 weeks), and extended observation (up to 24 weeks) phases. Secondary efficacy assessments were Clinical Global Impression-Improvement (clinical efficacy), Behavior Rating Inventory of Executive Function Scale (BRIEF; executive function behaviors), and Weiss Functional Impairment Rating Scale (social function). Validity of remission was assessed by comparing the function measures (BRIEF and Weiss′s) between patients who achieved remission and those who did not. At week 8, 69.3% (151/218) of patients achieved remission by definition 1, and 73.2% (161/220) by definition 2. At weeks 8 and 24, the remission group had significantly lower BRIEF, Weiss′s, and Clinical Global Impression-Improvement scores (P < 0.001 for all) compared with the nonremission group. Overall, treatment with osmotic-release oral-system methylphenidate was well tolerated, with increased remission rates in children with ADHD.

语种: 英语
所属项目编号: 2014CB846100
项目资助者: Xi&prime ; an Janssen Pharmaceutical Ltd ; Major State Basic Research Development Program of China (973 Program)
WOS记录号: WOS:000361036100006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58044
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Shanghai Changzheng Hosp, Shanghai, Peoples R China
2.Peking Univ, Hosp 6, Inst Mental Hlth, Natl Clin Res Ctr Mental Disorders, Beijing 100871, Peoples R China
3.Jilin Univ, Hosp 1, Changchun 130023, Jilin Province, Peoples R China
4.Nanjing Med Univ, Nanjing Brain Hosp, Nanjing, Jiangsu, Peoples R China
5.Capital Med Univ, Beijing Childrens Hosp, Beijing, Peoples R China
6.Soochow Univ, Affiliated Childrens Hosp, Suzhou, Peoples R China
7.Nanjing Med Univ, Nanjing Childrens Hosp, Nanjing, Jiangsu, Peoples R China
8.Xian Janssen Pharmaceut Ltd, Janssen Res & Dev Dept, Beijing, Peoples R China

Recommended Citation:
Su, Yi,Li, Haibo,Chen, Yixin,et al. Remission Rate and Functional Outcomes During a 6-Month Treatment With Osmotic-Release Oral-System Methylphenidate in Children With Attention-Deficit/Hyperactivity Disorder[J]. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY,2015,35(5):525-534.
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