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学科主题: 药物依赖
题名:
Microstructure Abnormalities in Adolescents with Internet Addiction Disorder
作者: Yuan, Kai1; Qin, Wei1; Wang, Guihong1,2; Zeng, Fang3; Zhao, Liyan4; Yang, Xuejuan1; Liu, Peng1; Liu, Jixin1; Sun, Jinbo1; von Deneen, Karen M.1; Gong, Qiyong5; Liu, Yijun6,7; Tian, Jie1,8
刊名: PLOS ONE
发表日期: 2011-06-03
DOI: 10.1371/journal.pone.0020708
卷: 6, 期:6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: HEROIN-DEPENDENT INDIVIDUALS ; FRONTAL-SUBCORTICAL CIRCUITS ; ANTERIOR CINGULATE CORTEX ; SUBJECT DIFFUSION DATA ; PRIMARY MOTOR CORTEX ; COGNITIVE-DEVELOPMENT ; RESPONSE-INHIBITION ; PREFRONTAL CORTEX ; ORBITOFRONTAL CORTEX ; SPATIAL STATISTICS
英文摘要:

Background: Recent studies suggest that internet addiction disorder (IAD) is associated with structural abnormalities in brain gray matter. However, few studies have investigated the effects of internet addiction on the microstructural integrity of major neuronal fiber pathways, and almost no studies have assessed the microstructural changes with the duration of internet addiction.

Methodology/Principal Findings: We investigated the morphology of the brain in adolescents with IAD (N = 18) using an optimized voxel-based morphometry (VBM) technique, and studied the white matter fractional anisotropy (FA) changes using the diffusion tensor imaging (DTI) method, linking these brain structural measures to the duration of IAD. We provided evidences demonstrating the multiple structural changes of the brain in IAD subjects. VBM results indicated the decreased gray matter volume in the bilateral dorsolateral prefrontal cortex (DLPFC), the supplementary motor area (SMA), the orbitofrontal cortex (OFC), the cerebellum and the left rostral ACC (rACC). DTI analysis revealed the enhanced FA value of the left posterior limb of the internal capsule (PLIC) and reduced FA value in the white matter within the right parahippocampal gyrus (PHG). Gray matter volumes of the DLPFC, rACC, SMA, and white matter FA changes of the PLIC were significantly correlated with the duration of internet addiction in the adolescents with IAD.

Conclusions: Our results suggested that long-term internet addiction would result in brain structural alterations, which probably contributed to chronic dysfunction in subjects with IAD. The current study may shed further light on the potential brain effects of IAD.

语种: 英语
所属项目编号: 30970774 ; 60901064 ; 30873462 ; 30870685 ; 81000641 ; 81000640 ; 81071217 ; 31028010 ; 81071137 ; 2011CB707700 ; 2011CB707702 ; 2008AA01Z411
项目资助者: CAS ; National Natural Science Foundation of China ; Project for the National Key Basic Research and Development Program (973) ; 863 program ; Fundamental Research Funds for the Central Universities
WOS记录号: WOS:000291355500036
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58045
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian, Shaanxi, Peoples R China
2.Xidian Univ, Dept Appl Math, Xian, Shaanxi, Peoples R China
3.Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Chengdu, Sichuan, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
5.Sichuan Univ, Dept Radiol, Ctr Med Imaging, Huaxi MR Res Ctr HMRRC,W China Hosp, Chengdu 610064, Sichuan, Peoples R China
6.Univ Florida, Dept Psychiat, McKnight Brain Inst, Gainesville, FL 32611 USA
7.Univ Florida, Dept Neurosci, McKnight Brain Inst, Gainesville, FL 32610 USA
8.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China

Recommended Citation:
Yuan, Kai,Qin, Wei,Wang, Guihong,et al. Microstructure Abnormalities in Adolescents with Internet Addiction Disorder[J]. PLOS ONE,2011,6(6).
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