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Microstructure Abnormalities in Adolescents with Internet Addiction Disorder
Yuan, Kai1; Qin, Wei1; Wang, Guihong1,2; Zeng, Fang3; Zhao, Liyan4; Yang, Xuejuan1; Liu, Peng1; Liu, Jixin1; Sun, Jinbo1; von Deneen, Karen M.1; Gong, Qiyong5; Liu, Yijun6,7; Tian, Jie1,8
刊名PLOS ONE
2011-06-03
DOI10.1371/journal.pone.0020708
6期:6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]HEROIN-DEPENDENT INDIVIDUALS ; FRONTAL-SUBCORTICAL CIRCUITS ; ANTERIOR CINGULATE CORTEX ; SUBJECT DIFFUSION DATA ; PRIMARY MOTOR CORTEX ; COGNITIVE-DEVELOPMENT ; RESPONSE-INHIBITION ; PREFRONTAL CORTEX ; ORBITOFRONTAL CORTEX ; SPATIAL STATISTICS
英文摘要

Background: Recent studies suggest that internet addiction disorder (IAD) is associated with structural abnormalities in brain gray matter. However, few studies have investigated the effects of internet addiction on the microstructural integrity of major neuronal fiber pathways, and almost no studies have assessed the microstructural changes with the duration of internet addiction.

Methodology/Principal Findings: We investigated the morphology of the brain in adolescents with IAD (N = 18) using an optimized voxel-based morphometry (VBM) technique, and studied the white matter fractional anisotropy (FA) changes using the diffusion tensor imaging (DTI) method, linking these brain structural measures to the duration of IAD. We provided evidences demonstrating the multiple structural changes of the brain in IAD subjects. VBM results indicated the decreased gray matter volume in the bilateral dorsolateral prefrontal cortex (DLPFC), the supplementary motor area (SMA), the orbitofrontal cortex (OFC), the cerebellum and the left rostral ACC (rACC). DTI analysis revealed the enhanced FA value of the left posterior limb of the internal capsule (PLIC) and reduced FA value in the white matter within the right parahippocampal gyrus (PHG). Gray matter volumes of the DLPFC, rACC, SMA, and white matter FA changes of the PLIC were significantly correlated with the duration of internet addiction in the adolescents with IAD.

Conclusions: Our results suggested that long-term internet addiction would result in brain structural alterations, which probably contributed to chronic dysfunction in subjects with IAD. The current study may shed further light on the potential brain effects of IAD.

语种英语
WOS记录号WOS:000291355500036
引用统计
被引频次:113[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58045
专题中国药物依赖性研究所
北京大学医学部管理机构_医学部
作者单位1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian, Shaanxi, Peoples R China
2.Xidian Univ, Dept Appl Math, Xian, Shaanxi, Peoples R China
3.Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Chengdu, Sichuan, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
5.Sichuan Univ, Dept Radiol, Ctr Med Imaging, Huaxi MR Res Ctr HMRRC,W China Hosp, Chengdu 610064, Sichuan, Peoples R China
6.Univ Florida, Dept Psychiat, McKnight Brain Inst, Gainesville, FL 32611 USA
7.Univ Florida, Dept Neurosci, McKnight Brain Inst, Gainesville, FL 32610 USA
8.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Yuan, Kai,Qin, Wei,Wang, Guihong,et al. Microstructure Abnormalities in Adolescents with Internet Addiction Disorder[J]. PLOS ONE,2011,6(6).
APA Yuan, Kai.,Qin, Wei.,Wang, Guihong.,Zeng, Fang.,Zhao, Liyan.,...&Tian, Jie.(2011).Microstructure Abnormalities in Adolescents with Internet Addiction Disorder.PLOS ONE,6(6).
MLA Yuan, Kai,et al."Microstructure Abnormalities in Adolescents with Internet Addiction Disorder".PLOS ONE 6.6(2011).
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