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学科主题: 临床医学
题名:
A novel molecular marker for early detection and evaluating prognosis of gastric cancer: N-myc downstream regulated gene-1 (NDRG1)
作者: Jiang, Kewei; Shen, Zhanlong; Ye, Yingjiang; Yang, Xiaodong; Wang, Shan
关键词: Apoptosis ; gastric cancer ; invasion ; metastasis ; NDRG1 ; proliferation
刊名: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
发表日期: 2010-08-01
DOI: 10.3109/00365520903242580
卷: 45, 期:7-8, 页:898-908
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: DIFFERENTIATION-RELATED GENE ; SUPPRESSOR GENE ; TUMOR-METASTASIS ; HEPATOCELLULAR-CARCINOMA ; PROSTATE-CANCER ; BREAST-CANCER ; EXPRESSION ; DRG-1 ; HYPOXIA ; CELLS
英文摘要:

Objective. N-myc downstream regulated gene-1 (NDRG1) is known as a differentiation-related gene that plays important roles in cell differentiation, organ formation, and embryonic development. NDRG1 was recently found to significantly down regulate in a variety of different neoplasms. Its significance in gastric cancer has not been studied. Materials and methods. NDRG1 was detected at its protein level by immunohistochemistry in formalin-fixed and paraffin-embedded sections with a total of 110 pair gastric cancer specimens including tumor and corresponding paraneoplastic tissues; NDRG1 mRNA was detected by real time-polymerase chain reaction. Meanwhile, the correlations between NDRG1 and clinicopathological factors were observed. Overexpression of NDRG1 has influence on the biological behavior of gastric cancer cell, which was detected by cell growth assay, apoptosis assay, and in vitro motility and invasion assay. Results. NDRG1 protein was down regulated in gastric cancer tissues, and the NDRG1 low expression rate was 73.6% (79/110). Moreover, NDRG1 expression has a significant inverse correlation with tumor stromal invasion, lymph node metastasis, pathological stage, but not with distant metastasis. The patients with low NDRG1 expression had a significantly shorter survival opportunity than those with high NDRG1 expression. In addition, overexpression of NDRG1 induced early apoptosis and inhibited SGC7901 cell proliferation and its motility and invasion capability. Conclusions. NDRG1 plays a significant role in carcinogenesis and preventing the metastasis and invasion of gastric cancer cells. NDRG1 could be developed as a marker contributing to diagnosis and evaluating prognosis in gastric cancer, as well as a potential therapeutic target of gastric cancer.

语种: 英语
WOS记录号: WOS:000281039400016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58046
Appears in Collections:北京大学第二临床医学院_胃肠外科_期刊论文

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作者单位: Peking Univ, Dept Surg Gastroenterol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Jiang, Kewei,Shen, Zhanlong,Ye, Yingjiang,et al. A novel molecular marker for early detection and evaluating prognosis of gastric cancer: N-myc downstream regulated gene-1 (NDRG1)[J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY,2010,45(7-8):898-908.
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