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学科主题: 临床医学
题名:
The Role of Sulfur Dioxide in the Regulation of Mitochondrion-Related Cardiomyocyte Apoptosis in Rats with Isopropylarterenol-Induced Myocardial Injury
作者: Jin, Hongfang1; Liu, Angie Dong2; Holmberg, Lukas2; Zhao, Manman1; Chen, Siyao1; Yang, Jinyan1; Sun, Yan1; Chen, Shanshan1; Tang, Chaoshu3,4; Du, Junbao1,3
关键词: isopropylarterenol ; sulfur dioxide ; myocardium ; apoptosis ; mitochondrial membrane potential
刊名: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
发表日期: 2013-05-01
DOI: 10.3390/ijms140510465
卷: 14, 期:5, 页:10465-10482
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: ENDOPLASMIC-RETICULUM STRESS ; CYTOCHROME-C ; CELL APOPTOSIS ; AIR-POLLUTION ; DEATH ; PROTEIN ; ISOPROTERENOL ; BAX ; ACTIVATION ; MECHANISMS
英文摘要:

The authors investigated the regulatory effects of sulfur dioxide (SO2) on myocardial injury induced by isopropylarterenol (ISO) hydrochloride and its mechanisms. Wistar rats were divided into four groups: control group, ISO group, ISO plus SO2 group, and SO2 only group. Cardiac function was measured and cardiomyocyte apoptosis was detected. Bcl-2, bax and cytochrome c (cytc) expressions, and caspase-9 and caspase-3 activities in the left ventricular tissues were examined in the rats. The opening status of myocardial mitochondrial permeability transition pore (MPTP) and membrane potential were analyzed. The results showed that ISO-treated rats developed heart dysfunction and cardiac injury. Furthermore, cardiomyocyte apoptosis in the left ventricular tissues was augmented, left ventricular tissue bcl-2 expression was down-regulated, bax expression was up-regulated, mitochondrial membrane potential was significantly reduced, MPTP opened, cytc release from mitochondrion into cytoplasm was significantly increased, and both caspase-9 and caspase-3 activities were increased. Administration of an SO2 donor, however, markedly improved heart function and relieved myocardial injury of the ISO-treated rats; it lessened cardiomyocyte apoptosis, up-regulated myocardial bcl-2, down-regulated bax expression, stimulated mitochondrial membrane potential, closed MPTP, and reduced cytc release as well as caspase-9 and caspase-3 activities in the left ventricular tissue. Hence, SO2 attenuated myocardial injury in association with the inhibition of apoptosis in myocardial tissues, and the bcl-2/cytc/caspase-9/caspase-3 pathway was possibly involved in this process.

语种: 英语
所属项目编号: 2012CB517806 ; 2011CB503904 ; 81121061 ; 81070111 ; 31130030 ; NCET-11-0005
项目资助者: Major Basic Research Program of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talent of Ministry of Education of China
WOS记录号: WOS:000319441500100
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58047
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Linkoping Univ, Dept Med & Hlth Sci, S-58183 Linkoping, Sweden
3.Minist Educ, Mol Cardiol Lab, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China

Recommended Citation:
Jin, Hongfang,Liu, Angie Dong,Holmberg, Lukas,et al. The Role of Sulfur Dioxide in the Regulation of Mitochondrion-Related Cardiomyocyte Apoptosis in Rats with Isopropylarterenol-Induced Myocardial Injury[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2013,14(5):10465-10482.
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