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The synthesis, distribution, and anti-hepatic cancer activity of YSL
Ding, WF; Zhang, JL; Yao, Z; Lu, R; Wu, DZ; Li, GF; Shen, ZL; Sun, YJ; Lin, G; Wang, C; Zhao, M; Peng, SQ
关键词Ysl Distribution [3 Anti-hepatic Cancer 5-h-3-tyr]-ser-leu-oh
刊名BIOORGANIC & MEDICINAL CHEMISTRY
2004-09-15
DOI10.1016/j.bmc.2004.06.030
12期:18页:4989-4994
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
关键词[WOS]PEPTIDE ; PHARMACOKINETICS ; SEQUENCE
英文摘要

YSL was prepared stepwise from C terminal to N terminal with the side chain un-protective amino acids, Boc-Leu-OMe, Boc-Ser-OH, and Boc-Tyr-OH, as the starting materials in 39.5% total yield (31.2g/per batch). With the side chain un-protective Boc-(3,5-dibromo)-Tyr-OH and HCl.Ser-Leu-OMe as the starting materials (3,5-H-3-Tyr)-Ser-Leu-OH was obtained in 29% yield. The determination of radioactive quantity in the urine and feces indicated that even after the administration for [30h only 8.4% (5.35% in urine and 3.05% in feces) of total radioactive quantity from the metabolite of [3,5-H-3-Tyr]-Ser-Leu-OH were monitored. The distribution study revealed the relative accumulation level of the individual tissue was arranged in the sequence of spleen > liver > kidney > lung > heart > muscle > brain. Selecting hepatic cancer as the target YSL significantly increased the survival time of H22 tumor cells implanted mice. (C) 2004 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000223845300024
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58053
专题北京大学药学院
作者单位1.China Pharmaceut Univ, Nanjing 210009, Peoples R China
2.Tianjin Med Univ, Tianjin 300070, Peoples R China
3.Kangzhe Pharmaceut Ltd Co, Shenzhen 518029, Peoples R China
4.Capital Univ Med Sch, Coll Pharmaceut Sci, Beijing 100054, Peoples R China
5.Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China
6.China Inst Atom Energy, Dept Isotopes, Beijing 102413, Peoples R China
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GB/T 7714
Ding, WF,Zhang, JL,Yao, Z,et al. The synthesis, distribution, and anti-hepatic cancer activity of YSL[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2004,12(18):4989-4994.
APA Ding, WF.,Zhang, JL.,Yao, Z.,Lu, R.,Wu, DZ.,...&Peng, SQ.(2004).The synthesis, distribution, and anti-hepatic cancer activity of YSL.BIOORGANIC & MEDICINAL CHEMISTRY,12(18),4989-4994.
MLA Ding, WF,et al."The synthesis, distribution, and anti-hepatic cancer activity of YSL".BIOORGANIC & MEDICINAL CHEMISTRY 12.18(2004):4989-4994.
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