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学科主题临床医学
Tumor-Infiltrating Dendritic Cells May Be Used as Clinicopathologic Prognostic Factors in Endometrial Carcinoma
Zhao Lijun1; Zhao Xin1,2; Shen Danhua3; Li Xiaoping1; Wang Jianliu1; Wang Huilan2; Wei Lihui1
关键词Dendritic Cell S100 Hla-dr Cd1a Endometrial Endometrioid Adenocarcinoma
刊名INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
2012-06-01
DOI10.1097/IGC.0b013e31825401c6
22期:5页:836-841
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Obstetrics & Gynecology
资助者Peking University Health Science Centre ; Peking University Health Science Centre
研究领域[WOS]Oncology ; Obstetrics & Gynecology
关键词[WOS]COLORECTAL-CANCER ; EXPRESSION ; BREAST
英文摘要

Objective: To investigate the distribution of dendritic cells (DCs) at different development status in endometrial carcinoma and their relationship with clinical pathology.

Methods: Samples were collected from 95 patients with endometrial endometrioid adenocarcinoma treated in Peking University People′s Hospital from 2002 to 2010. Normal endometrial tissue was obtained from 40 women and served as controls. Immunohistochemistry was used to detect the expression of S100-, human leukocyte antigen (HLA)- DR, and CD1a-positive DCs within the tumor glandular epithelium, the surrounding tumor interstitial tissue, and the equivalent normal endometrial tissue. The relationship of these DCs with clinical stage, pathology grade, myometrial invasion, and lymph node metastasis was analyzed.

Results: The rate of S100-positive DCs in the endometrial endometrioid adenocarcinoma glandular epithelium samples from the 95 patients was 48.4% (46/95), and that of the HLA-DR-positive DCs was 27.4% (26/95), which were both significantly higher (P < 0.05) than that in the control group. CD la-positive DC was rarely expressed in endometrial endometrioid adenocarcinoma glandular epithelium. The rates of the S100- and HLA-DR-positive DCs in tumor interstitial tissue were similar to that of the control group (both, P > 0.05). The proportion of invasion of the S100- and HLA-DR positive DCs was negatively correlated with the clinical stage and lymph node metastasis but was not correlated with the pathological grade and myometrial invasion.

Conclusions: Dendritic cell invasion was detected in endometrial endometrioid adenocarcinoma. S100- and HLA-DR positive DCs may have functions related to the delay of tumor progression and lymph node metastasis.

语种英语
所属项目编号BMU20100064
资助者Peking University Health Science Centre ; Peking University Health Science Centre
WOS记录号WOS:000305316300021
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58054
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100044, Peoples R China
2.Hebei Med Univ, Hosp 2, Dept Obstet & Gynecol, Shijiazhuang, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Pathol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Zhao Lijun,Zhao Xin,Shen Danhua,et al. Tumor-Infiltrating Dendritic Cells May Be Used as Clinicopathologic Prognostic Factors in Endometrial Carcinoma[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,2012,22(5):836-841.
APA Zhao Lijun.,Zhao Xin.,Shen Danhua.,Li Xiaoping.,Wang Jianliu.,...&Wei Lihui.(2012).Tumor-Infiltrating Dendritic Cells May Be Used as Clinicopathologic Prognostic Factors in Endometrial Carcinoma.INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,22(5),836-841.
MLA Zhao Lijun,et al."Tumor-Infiltrating Dendritic Cells May Be Used as Clinicopathologic Prognostic Factors in Endometrial Carcinoma".INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 22.5(2012):836-841.
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