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学科主题: 临床医学
题名:
Clinical and pathological characterization of patients with microscopic polyangiitis with medium artery involvement
作者: Zhao, MH; Sun, QZ; Wang, HY
关键词: microscopic polyangntis ; medium vessel vasculitides ; anti-neutrophil ; cytoplasmic antibodies
刊名: RENAL FAILURE
发表日期: 2003
DOI: 10.1081/JDI-120026034
卷: 25, 期:6, 页:989-995
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES ; POLYARTERITIS-NODOSA ; VASCULITIDES
英文摘要:

Objective. To study the clinical and pathological characteristics of patients with microscopic polyangiitis (MPA) with medium artery involvement. Methods. Hospitalized patients with MPA in recent two years were retrospectively studied. Their clinical and pathological features were compared between patients with and without renal medium artery involvement. Results. Thirty-nine patients had renal pathology confirmed MPA. Nine cases were with medium artery involvement. For the 30 patients without medium artery involvement, 24/30 had crescentic glomerulonephritis and 11/30 also had focal segmental glomerular fibrinoid necrosis; clinically, 21/30 patients were pANCA/MPO-ANCA positive, 26/30 had acute renal failure with an average duration of 14 weeks before MPA was diagnosed, eight cases achieved complete remission after intensive immunosuppressive therapy. Nine MPA patients had medium artery involvement, manifested as segmental fibrinoid necrosis of major branch of arcuate artery, glomerulus ischemia was predominant, but crescentic lesions were mild, none of them reached crescentic glomerulonephritis. Five of the nine were pANCA/MPO-ANCA positive, eight out of the nine patients had acute renal failure with an average duration of eight weeks before diagnosed, seven of the nine achieved complete remission after intensive immunosuppressive therapy. In comparison, MPA with medium artery involvement had a shorter duration ( p < 0.05), less crescentic glomerulonephritis in patients with acute renal failure (p < 0,01) and more patients achieved complete remission after treatment (p < 0.05). Conclusion. In present study, about 23% MPA patients had medium artery involvement and their impaired renal function is mainly due to extensive glomerular ischemia. These patients progressed to acute renal failure quicker and responded to therapy better.

语种: 英语
WOS记录号: WOS:000187078100011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58063
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: Peking Univ, First Hosp, Inst Nephrol, Beijing 100034, Peoples R China

Recommended Citation:
Zhao, MH,Sun, QZ,Wang, HY. Clinical and pathological characterization of patients with microscopic polyangiitis with medium artery involvement[J]. RENAL FAILURE,2003,25(6):989-995.
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