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学科主题: 药物依赖
题名:
Effects of polyinosinic-polycytidylic acid (Poly I:C) on naloxone-precipitated withdrawal in morphine-dependent mice
作者: Chen, Lei; Zhai, Haifeng; Lu, Lin; Chen, Suqing; Ning, Yaqing; Wang, Weiping
关键词: Immune challenge ; Morphine ; Poly I:C ; Tail suspension test
刊名: NEUROSCIENCE LETTERS
发表日期: 2011-01-10
DOI: 10.1016/j.neulet.2010.10.052
卷: 487, 期:3, 页:341-344
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: OPIATE WITHDRAWAL ; INTERFERON-ALPHA ; IMMUNE-SYSTEM ; PHYSICAL-DEPENDENCE ; ADDICTED RATS ; DEPRESSION ; BRAIN ; MODEL ; RNA ; ABSTINENCE
英文摘要:

Viral infections are frequently found in opioid addicts, subjecting them to immune challenge. However, the effects of immune challenge on opioid withdrawal are not fully understood. In the present study, mice were intraperitoneally injected with 2 mg/kg polyinosinic-polycytidylic acid (Poly I:C, a viral mimetic) for 3 days to induce an immune challenge, followed by subcutaneous injection of morphine 3 times per day for 3 days to induce morphine dependence. Withdrawal was induced by an intraperitoneal injection of 5 mg/kg naloxone, an opioid receptor antagonist. The results showed that Poly I:C pretreatment did not alter body weight loss, jumping behavior, or locomotion during naloxone-precipitated withdrawal. In contrast, Poly I:C pretreatment significantly increased immobility time in the tail suspension test. Our findings suggest that Poly I:C-induced immune challenge has no effects on acute physical opioid withdrawal symptoms but facilitates depression-like behavior. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 30873051 ; 2007CB512302
项目资助者: National Science Foundation ; National Basic Research Program ; Scientific Research Foundation for Returned Overseas Chinese Scholars from the State Education Ministry of China
WOS记录号: WOS:000286697400020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58065
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100191, Peoples R China

Recommended Citation:
Chen, Lei,Zhai, Haifeng,Lu, Lin,et al. Effects of polyinosinic-polycytidylic acid (Poly I:C) on naloxone-precipitated withdrawal in morphine-dependent mice[J]. NEUROSCIENCE LETTERS,2011,487(3):341-344.
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