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Effects of polyinosinic-polycytidylic acid (Poly I:C) on naloxone-precipitated withdrawal in morphine-dependent mice
Chen, Lei; Zhai, Haifeng; Lu, Lin; Chen, Suqing; Ning, Yaqing; Wang, Weiping
关键词Immune Challenge Morphine Poly i:c Tail Suspension Test
刊名NEUROSCIENCE LETTERS
2011-01-10
DOI10.1016/j.neulet.2010.10.052
487期:3页:341-344
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
资助者National Science Foundation ; National Basic Research Program ; Scientific Research Foundation for Returned Overseas Chinese Scholars from the State Education Ministry of China ; National Science Foundation ; National Basic Research Program ; Scientific Research Foundation for Returned Overseas Chinese Scholars from the State Education Ministry of China
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]OPIATE WITHDRAWAL ; INTERFERON-ALPHA ; IMMUNE-SYSTEM ; PHYSICAL-DEPENDENCE ; ADDICTED RATS ; DEPRESSION ; BRAIN ; MODEL ; RNA ; ABSTINENCE
英文摘要

Viral infections are frequently found in opioid addicts, subjecting them to immune challenge. However, the effects of immune challenge on opioid withdrawal are not fully understood. In the present study, mice were intraperitoneally injected with 2 mg/kg polyinosinic-polycytidylic acid (Poly I:C, a viral mimetic) for 3 days to induce an immune challenge, followed by subcutaneous injection of morphine 3 times per day for 3 days to induce morphine dependence. Withdrawal was induced by an intraperitoneal injection of 5 mg/kg naloxone, an opioid receptor antagonist. The results showed that Poly I:C pretreatment did not alter body weight loss, jumping behavior, or locomotion during naloxone-precipitated withdrawal. In contrast, Poly I:C pretreatment significantly increased immobility time in the tail suspension test. Our findings suggest that Poly I:C-induced immune challenge has no effects on acute physical opioid withdrawal symptoms but facilitates depression-like behavior. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

语种英语
所属项目编号30873051 ; 2007CB512302
资助者National Science Foundation ; National Basic Research Program ; Scientific Research Foundation for Returned Overseas Chinese Scholars from the State Education Ministry of China ; National Science Foundation ; National Basic Research Program ; Scientific Research Foundation for Returned Overseas Chinese Scholars from the State Education Ministry of China
WOS记录号WOS:000286697400020
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58065
Collection中国药物依赖性研究所
作者单位Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Chen, Lei,Zhai, Haifeng,Lu, Lin,et al. Effects of polyinosinic-polycytidylic acid (Poly I:C) on naloxone-precipitated withdrawal in morphine-dependent mice[J]. NEUROSCIENCE LETTERS,2011,487(3):341-344.
APA Chen, Lei,Zhai, Haifeng,Lu, Lin,Chen, Suqing,Ning, Yaqing,&Wang, Weiping.(2011).Effects of polyinosinic-polycytidylic acid (Poly I:C) on naloxone-precipitated withdrawal in morphine-dependent mice.NEUROSCIENCE LETTERS,487(3),341-344.
MLA Chen, Lei,et al."Effects of polyinosinic-polycytidylic acid (Poly I:C) on naloxone-precipitated withdrawal in morphine-dependent mice".NEUROSCIENCE LETTERS 487.3(2011):341-344.
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