IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Postauricular hypodermic injection to treat inner ear disorders: experimental feasibility study using magnetic resonance imaging and pharmacokinetic comparison
Li, J.1; Yu, L.1; Xia, R.2; Gao, F.2; Luo, W.3; Jing, Y.1
关键词Perilymph Ear Inner Pharmacokinetics Administration Gadolinium Transcutaneous Magnetic Resonance Imaging
刊名JOURNAL OF LARYNGOLOGY AND OTOLOGY
2013-03-01
DOI10.1017/S0022215113000017
127期:3页:239-245
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Otorhinolaryngology
资助者National Natural Science Foundation of China ; Capital Medical Development Scientific Research Foundation ; National Natural Science Foundation of China ; Capital Medical Development Scientific Research Foundation
研究领域[WOS]Otorhinolaryngology
关键词[WOS]ROUND WINDOW MEMBRANE ; LOCAL-DRUG DELIVERY ; DTPA-BMA UPTAKE ; PERMEABILITY ; GADOLINIUM ; PERILYMPH ; COCHLEA ; MRI ; LABYRINTH
英文摘要

Background: To investigate the feasibility of postauricular hypodermic injection for treating inner ear disorders, we compared perilymph pharmacokinetics for postauricular versus intravenous injection, using magnetic resonance imaging, in an animal model.

Methods: Twelve albino guinea pigs were divided randomly into two groups and administered gadopentetate dimeglumine via either a postauricular or an intravenous bolus injection. A 7.0 Tesla magnetic resonance imaging system was used to assess the signal intensities of gadolinium-enhanced images of the cochlea, as a biomarker for changes in gadopentetate dimeglumine concentration in the perilymph. Pharmacokinetic parameters were calculated based on these signal intensity values.

Results: Guinea pigs receiving postauricular injection showed longer times to peak signal intensity, longer elimination half-life, longer mean residence time and a greater area under the signal-time curve (from pre-injection to the last time point) (p < 0.05).

Conclusion: Postauricular injection shows potential as an efficient drug delivery route for the treatment of inner ear disorders.

语种英语
所属项目编号81070780 ; 20091015
资助者National Natural Science Foundation of China ; Capital Medical Development Scientific Research Foundation ; National Natural Science Foundation of China ; Capital Medical Development Scientific Research Foundation
WOS记录号WOS:000317234400005
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58068
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100871, Peoples R China
2.Sichuan Univ, West China Hosp, Dept Radiol & Mol Imaging Ctr, Chengdu 610064, Peoples R China
3.Chongqing Univ Med Sci, Affiliated Hosp 2, Dept Otolaryngol Head & Neck Surg, Chongqing, Peoples R China
推荐引用方式
GB/T 7714
Li, J.,Yu, L.,Xia, R.,et al. Postauricular hypodermic injection to treat inner ear disorders: experimental feasibility study using magnetic resonance imaging and pharmacokinetic comparison[J]. JOURNAL OF LARYNGOLOGY AND OTOLOGY,2013,127(3):239-245.
APA Li, J.,Yu, L.,Xia, R.,Gao, F.,Luo, W.,&Jing, Y..(2013).Postauricular hypodermic injection to treat inner ear disorders: experimental feasibility study using magnetic resonance imaging and pharmacokinetic comparison.JOURNAL OF LARYNGOLOGY AND OTOLOGY,127(3),239-245.
MLA Li, J.,et al."Postauricular hypodermic injection to treat inner ear disorders: experimental feasibility study using magnetic resonance imaging and pharmacokinetic comparison".JOURNAL OF LARYNGOLOGY AND OTOLOGY 127.3(2013):239-245.
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