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Organochlorine pesticide levels inmaternal serumand risk of neural tube defects in offspring in Shanxi Province, China: A case-control study
Wang, Bin1; Yi, Deqing1; Jin, Lei1; Li, Zhiwen1; Liu, Jufen1; Zhang, Yali1; Qiu, Xinghua3,4; Liu, Wenxin2; Tao, Shu2; Ren, Aiguo1
关键词Neural Tube Defect Risk Organochlorine Pesticides Maternal Serum Case-control Study
刊名SCIENCE OF THE TOTAL ENVIRONMENT
2014-08-15
DOI10.1016/j.scitotenv.2014.05.075
490页:1037-1043
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Environmental Sciences
研究领域[WOS]Environmental Sciences & Ecology
关键词[WOS]PERSISTENT ORGANIC POLLUTANTS ; HUMAN BLOOD-PLASMA ; POLYCHLORINATED-BIPHENYLS ; EXPOSURE ; URBAN ; OCPS ; CONTAMINANTS ; ASSOCIATION ; INHABITANTS ; METABOLITES
英文摘要

Organochlorine pesticides (OCPs) in placental tissue have been reported to be associated with an increased risk for fetal neural tube defects (NTDs). Our case-control study was performed to explore the association between maternal serum OCP concentration and NTD risk in offspring. Serum samples were collected from 117 mothers who delivered NTD infants (case group) and 121 mothers who delivered healthy infants (control group). Only three of the 25 OCPs were detected in more than half of the maternal serum samples. The median concentration of total OCPs in the case group was significantly higher than that of the control group. However, no dose-response relationships between higher levels of any individual OCPs or total OCPs and the risk of NTDs or subtypes were observed in either the unadjusted binary unconditional logistic regression model or the model adjusted by potential confounders. We conclude that no clear association between maternal serum OCP residues and NTD risk in offspring was observed in this population.

Capsule: No clear association between maternal serum levels of organochlorine pesticides and risk of neural tube defects in offspring was observed for a Chinese population. (C) 2014 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000347293800110
项目编号31371523 ; 31071315 ; 41390243 ; ES021006
资助机构National Natural Science Foundation of China ; NIH
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58072
专题北京大学公共卫生学院
北京大学医学部管理机构_医学部
北京大学公共卫生学院_卫计委生育健康重点实验室
作者单位1.Peking Univ, Inst Reprod & Child Hlth, Sch Publ Hlth, Minist Hlth Key Lab Reprod Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Coll Urban & Environm Sci, Lab Earth Surface Proc, Beijing 100871, Peoples R China
3.Peking Univ, State Key Joint Lab Environm Simulat & Pollut Con, Coll Environm Sci & Engn, Beijing 100871, Peoples R China
4.Peking Univ, Ctr Environm & Hlth, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Wang, Bin,Yi, Deqing,Jin, Lei,et al. Organochlorine pesticide levels inmaternal serumand risk of neural tube defects in offspring in Shanxi Province, China: A case-control study[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2014,490:1037-1043.
APA Wang, Bin.,Yi, Deqing.,Jin, Lei.,Li, Zhiwen.,Liu, Jufen.,...&Ren, Aiguo.(2014).Organochlorine pesticide levels inmaternal serumand risk of neural tube defects in offspring in Shanxi Province, China: A case-control study.SCIENCE OF THE TOTAL ENVIRONMENT,490,1037-1043.
MLA Wang, Bin,et al."Organochlorine pesticide levels inmaternal serumand risk of neural tube defects in offspring in Shanxi Province, China: A case-control study".SCIENCE OF THE TOTAL ENVIRONMENT 490(2014):1037-1043.
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