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学科主题: 公共卫生
题名:
Organochlorine pesticide levels inmaternal serumand risk of neural tube defects in offspring in Shanxi Province, China: A case-control study
作者: Wang, Bin1; Yi, Deqing1; Jin, Lei1; Li, Zhiwen1; Liu, Jufen1; Zhang, Yali1; Qiu, Xinghua3,4; Liu, Wenxin2; Tao, Shu2; Ren, Aiguo1
关键词: Neural tube defect ; Risk ; Organochlorine pesticides ; Maternal serum ; Case-control study
刊名: SCIENCE OF THE TOTAL ENVIRONMENT
发表日期: 2014-08-15
DOI: 10.1016/j.scitotenv.2014.05.075
卷: 490, 页:1037-1043
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Environmental Sciences
研究领域[WOS]: Environmental Sciences & Ecology
关键词[WOS]: PERSISTENT ORGANIC POLLUTANTS ; HUMAN BLOOD-PLASMA ; POLYCHLORINATED-BIPHENYLS ; EXPOSURE ; URBAN ; OCPS ; CONTAMINANTS ; ASSOCIATION ; INHABITANTS ; METABOLITES
英文摘要:

Organochlorine pesticides (OCPs) in placental tissue have been reported to be associated with an increased risk for fetal neural tube defects (NTDs). Our case-control study was performed to explore the association between maternal serum OCP concentration and NTD risk in offspring. Serum samples were collected from 117 mothers who delivered NTD infants (case group) and 121 mothers who delivered healthy infants (control group). Only three of the 25 OCPs were detected in more than half of the maternal serum samples. The median concentration of total OCPs in the case group was significantly higher than that of the control group. However, no dose-response relationships between higher levels of any individual OCPs or total OCPs and the risk of NTDs or subtypes were observed in either the unadjusted binary unconditional logistic regression model or the model adjusted by potential confounders. We conclude that no clear association between maternal serum OCP residues and NTD risk in offspring was observed in this population.

Capsule: No clear association between maternal serum levels of organochlorine pesticides and risk of neural tube defects in offspring was observed for a Chinese population. (C) 2014 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 31371523 ; 31071315 ; 41390243 ; ES021006
项目资助者: National Natural Science Foundation of China ; NIH
WOS记录号: WOS:000347293800110
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58072
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Inst Reprod & Child Hlth, Sch Publ Hlth, Minist Hlth Key Lab Reprod Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Coll Urban & Environm Sci, Lab Earth Surface Proc, Beijing 100871, Peoples R China
3.Peking Univ, State Key Joint Lab Environm Simulat & Pollut Con, Coll Environm Sci & Engn, Beijing 100871, Peoples R China
4.Peking Univ, Ctr Environm & Hlth, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Bin,Yi, Deqing,Jin, Lei,et al. Organochlorine pesticide levels inmaternal serumand risk of neural tube defects in offspring in Shanxi Province, China: A case-control study[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2014,490:1037-1043.
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