IR@PKUHSC  > 北京大学第一临床医学院  > 放射治疗科
学科主题临床医学
Detection of abnormal visual cortex in children with amblyopia by voxel-based morphometry
Xiao, Jiang Xi; Xie, Sheng; Ye, Jin Tang; Liu, Hai Hua; Gan, Xiao Ling; Gong, Gao Lang; Jiang, Xue Xiang
刊名AMERICAN JOURNAL OF OPHTHALMOLOGY
2007-03-01
DOI10.1016/j.ajo.2006.11.039
143期:3页:489-493
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]MONKEY
英文摘要

center dot PURPOSE: To detect the abnormalities of gray matter in children with amblyopia by voxel-based morphometry (VBM).

center dot DESIGN: Prospective, nonrandomized clinical trial.

center dot METHODS: Thirteen children with amblyopia and 14 normally sighted children underwent magnetic resonance (MR) examination. The two groups were age,matched with a mean age of 5.8 years. In the amblyopia group, five children had strabismus amblyopia, and eight had anisometropic amblyopia. We analyzed the original 3-dimensional T I brain images using the VBM module within the widely used analysis software package SPM2 (Welcome Department of Cognitive Neurology, London, United Kingdom). After normalization, segmentation, and smoothing of the images, comparison between amblyopic and control groups was derived for the gray matter of the entire brain using parametric statistics.

center dot RESULTS: The results of VBM analysis indicated that the amblyopic group had decreased gray matter density in the middle frontal gyrus, parahippocampal gyrus, fusiform gyrus, inferior temporal gyrus of the left hemi, sphere, and the bilateral calcarine cortices. The radii of these regions ranged from 12 to 36 voxels. These abnormalities were consistent with morphologic changes in brain regions related to visual function.

center dot CONCLUSIONS: Using MR and VBM analysis, we detected morphologic changes in the visual cortex of children with amblyopia, which may indicate develop, mental abnormalities of visual cortex during the critical growth period.

语种英语
WOS记录号WOS:000244555700015
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58074
专题北京大学第一临床医学院_放射治疗科
作者单位1.Peking Univ First Hosp, Dept Radiol, Beijing 100034, Peoples R China
2.Peking Univ First Hosp, Dept Pediat Ophthalmol, Beijing 100034, Peoples R China
3.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing, Peoples R China
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Xiao, Jiang Xi,Xie, Sheng,Ye, Jin Tang,et al. Detection of abnormal visual cortex in children with amblyopia by voxel-based morphometry[J]. AMERICAN JOURNAL OF OPHTHALMOLOGY,2007,143(3):489-493.
APA Xiao, Jiang Xi.,Xie, Sheng.,Ye, Jin Tang.,Liu, Hai Hua.,Gan, Xiao Ling.,...&Jiang, Xue Xiang.(2007).Detection of abnormal visual cortex in children with amblyopia by voxel-based morphometry.AMERICAN JOURNAL OF OPHTHALMOLOGY,143(3),489-493.
MLA Xiao, Jiang Xi,et al."Detection of abnormal visual cortex in children with amblyopia by voxel-based morphometry".AMERICAN JOURNAL OF OPHTHALMOLOGY 143.3(2007):489-493.
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