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学科主题: 基础医学
题名:
The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund′s adjuvant
作者: Yu, Lu1; Yang, Fei1; Luo, Hao1; Liu, Feng-Yu1; Han, Ji-Sheng1,2,3; Xing, Guo-Gang1,2; Wan, You1,2,3
刊名: MOLECULAR PAIN
发表日期: 2008-12-04
DOI: 10.1186/1744-8069-4-61
卷: 4, 期:1
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: RECEPTOR 1 VR1 ; VANILLOID RECEPTOR-1 ; CAPSAICIN RECEPTORS ; HOT-PLATE ; EXPRESSION ; HYPERALGESIA ; ACTIVATION ; MICE ; NALTREXONE
英文摘要:

Background: The present study aims to investigate the role of transient receptor potential vanilloid 1 (TRPV1) in dorsal root ganglion (DRG) neurons in chronic pain including thermal hyperalgesia and mechanical allodynia. Chronic inflammatory nociception of rats was produced by intraplantar injection of complete Freund′s adjuvant (CFA) and data was collected until day 28 following injection.

Results: Thermal hyperalgesia was evident from day 1 to day 28 with peak at day 7, while mechanical allodynia persisted from day 1 to day 14 and was greatest at day 7. Intrathecal administration of AMG 9810 at day 7, a selective TRPV1 antagonist, significantly reduced thermal hyperalgesia and mechanical allodynia. TRPV1 expression in DRG detected by Western blotting was increased relative to baseline throughout the observation period. Double labeling of TRPV1 with neuronal marker neurofilament 200 (NF200), calcitonin gene-related peptide (CGRP) or isolectin B4 (IB4) was used to distinguish different subtypes of DRG neurons. TRPV1 expression was increased in the medium-sized myelinated A fiber (NF200 positive) neurons and in small non-peptidergic (IB4 positive) neurons from day 1 to day 14 and was increased in small peptidergic (CGRP positive) neurons from day 1 to day 28.

Conclusion: TRPV1 expression increases in all three types of DRG neurons after CFA injection and plays a role in CFA-induced chronic inflammatory pain including thermal hyperalgesia and mechanical allodynia.

语种: 英语
所属项目编号: 30700206 ; 30600173 ; 30570566 ; 2007CB512501
项目资助者: National Natural Science Foundation of China ; "111" Project of the Ministry of Education of China ; "973" Program of the Ministry of Science and Technology of China
WOS记录号: WOS:000263592400001
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58075
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Neurosci Res Inst, Beijing 100871, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing 100871, Peoples R China
3.Minist Publ Hlth, Minist Educ, Key Lab Neurosci, Beijing 100191, Peoples R China

Recommended Citation:
Yu, Lu,Yang, Fei,Luo, Hao,et al. The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund′s adjuvant[J]. MOLECULAR PAIN,2008,4(1).
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