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学科主题基础医学
The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund′s adjuvant
Yu, Lu1; Yang, Fei1; Luo, Hao1; Liu, Feng-Yu1; Han, Ji-Sheng1,2,3; Xing, Guo-Gang1,2; Wan, You1,2,3
刊名MOLECULAR PAIN
2008-12-04
DOI10.1186/1744-8069-4-61
4期:1
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]RECEPTOR 1 VR1 ; VANILLOID RECEPTOR-1 ; CAPSAICIN RECEPTORS ; HOT-PLATE ; EXPRESSION ; HYPERALGESIA ; ACTIVATION ; MICE ; NALTREXONE
英文摘要

Background: The present study aims to investigate the role of transient receptor potential vanilloid 1 (TRPV1) in dorsal root ganglion (DRG) neurons in chronic pain including thermal hyperalgesia and mechanical allodynia. Chronic inflammatory nociception of rats was produced by intraplantar injection of complete Freund′s adjuvant (CFA) and data was collected until day 28 following injection.

Results: Thermal hyperalgesia was evident from day 1 to day 28 with peak at day 7, while mechanical allodynia persisted from day 1 to day 14 and was greatest at day 7. Intrathecal administration of AMG 9810 at day 7, a selective TRPV1 antagonist, significantly reduced thermal hyperalgesia and mechanical allodynia. TRPV1 expression in DRG detected by Western blotting was increased relative to baseline throughout the observation period. Double labeling of TRPV1 with neuronal marker neurofilament 200 (NF200), calcitonin gene-related peptide (CGRP) or isolectin B4 (IB4) was used to distinguish different subtypes of DRG neurons. TRPV1 expression was increased in the medium-sized myelinated A fiber (NF200 positive) neurons and in small non-peptidergic (IB4 positive) neurons from day 1 to day 14 and was increased in small peptidergic (CGRP positive) neurons from day 1 to day 28.

Conclusion: TRPV1 expression increases in all three types of DRG neurons after CFA injection and plays a role in CFA-induced chronic inflammatory pain including thermal hyperalgesia and mechanical allodynia.

语种英语
WOS记录号WOS:000263592400001
项目编号30700206 ; 30600173 ; 30570566 ; 2007CB512501
资助机构National Natural Science Foundation of China ; "111" Project of the Ministry of Education of China ; "973" Program of the Ministry of Science and Technology of China
引用统计
被引频次:88[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58075
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
北京大学第二临床医学院_病理科
作者单位1.Peking Univ, Sch Basic Med Sci, Neurosci Res Inst, Beijing 100871, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing 100871, Peoples R China
3.Minist Publ Hlth, Minist Educ, Key Lab Neurosci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yu, Lu,Yang, Fei,Luo, Hao,等. The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund′s adjuvant[J]. MOLECULAR PAIN,2008,4(1).
APA Yu, Lu.,Yang, Fei.,Luo, Hao.,Liu, Feng-Yu.,Han, Ji-Sheng.,...&Wan, You.(2008).The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund′s adjuvant.MOLECULAR PAIN,4(1).
MLA Yu, Lu,et al."The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund′s adjuvant".MOLECULAR PAIN 4.1(2008).
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