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Heterosexual transmission of HIV and related risk factors among serodiscordant couples in Henan province, China
Wang Lan2; Wang Lu2; Smith, M. Kumi2; Li Li-ming1; Ming Shuai2; Lu Jun1; Cao Wei-hua1; He Wen-sheng3; Zhou Jian-ping3; Wang Ning2
关键词Hiv Serodiscordant Couples Seroconversion Rate Antiretroviral Therapy Treatment As Prevention
刊名CHINESE MEDICAL JOURNAL
2013-10-05
DOI10.3760/cma.j.issn.0366-6999.20123311
126期:19页:3694-3700
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]ANTIRETROVIRAL TREATMENT PROGRAM ; COMMERCIAL PLASMA DONORS ; DISCORDANT COUPLES ; PREVENTION ; INFECTION ; METAANALYSIS ; RETHINKING ; PREVALENCE ; TYPE-1 ; INDIA
英文摘要

Background HIV transmission between discordant couples has become an important source of new infections in China. To describe the seroconversion rate among serodiscordant couples and to identify salient behavioral and clinical risk factors including ART that affect heterosexual HIV transmission risk among couples in rural China.

Methods Longitudinal follow-up of an open cohort of HIV serodiscordant couples took place between 2007 and 2011 in Zhumadian, a city in southern Henan province in China, where blood plasma selling in 1990s led to a regional HIV epidemic. Annual follow-up included separate face-to-face interviews of husbands and wives, and HIV antibody testing for non-index partners. Cox proportional-hazard modeling was used to assess the relationship between HIV seroconversion and covariates of interest.

Results By the end of 2011, 4499 HIV serodiscordant couples had been enrolled in at least two follow-up interviews; 100 non-index partners seroconverted during the entire observation period for an incidence rate of 0.82 per 100 person-years (95% CI: 0.66-0.99). The incidence rates by the end of 2008, 2009, and 2010 were 2.14, 1.51, and 0.90 per 100 person-years respectively. Always using condoms in the past year of sex, gender of the index partner, frequency of sex, and ART exposure were all significant predictors of HIV seroconversion in the negative spouse. ART was highly protective against seroconversion whether the index partner was actively receiving treatment at the last follow-up (RR=0.05, 95% Cl, 0.01-0.16) or if the index partner had ever received ART (RR=0.01, 95% CI, 0.00, 0.12). The risk of seroconversion in the non-index spouse also decreased the longer the duration of the index partner′s exposure to ART.

Conclusions ART exposure and always using condom were highly protective against HIV seroconversion in the negative spouse. HIV incidence in serodiscordant couples has been decreasing over time, associated with ART treatment time within 7 years in the index partner. Gender of the index spouse and frequency of sex were also important predictors. Treatment as part of a combination prevention package may be a feasible method of HIV control in this population.

语种英语
WOS记录号WOS:000326426800018
项目编号2008ZX10001-003
资助机构Mega-Projects of the National Science Research for the 11th Five-Year Plan
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58076
专题北京大学公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, Beijing 102206, Peoples R China
3.Zhumadian Ctr Dis Control & Prevent, Zhumadian 463000, Henan, Peoples R China
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GB/T 7714
Wang Lan,Wang Lu,Smith, M. Kumi,et al. Heterosexual transmission of HIV and related risk factors among serodiscordant couples in Henan province, China[J]. CHINESE MEDICAL JOURNAL,2013,126(19):3694-3700.
APA Wang Lan.,Wang Lu.,Smith, M. Kumi.,Li Li-ming.,Ming Shuai.,...&Wang Ning.(2013).Heterosexual transmission of HIV and related risk factors among serodiscordant couples in Henan province, China.CHINESE MEDICAL JOURNAL,126(19),3694-3700.
MLA Wang Lan,et al."Heterosexual transmission of HIV and related risk factors among serodiscordant couples in Henan province, China".CHINESE MEDICAL JOURNAL 126.19(2013):3694-3700.
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