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Association study of neuregulin 1 gene with schizophrenia
Yang, JZ; Si, TM; Ruan, Y; Ling, YS; Han, YH; Wang, XL; Zhou, M; Zhang, HY; Kong, QM; Liu, C; Zhang, DR; Yu, YQ; Liu, SZ; Ju, GZ; Shu, L; Ma, DL; Zhang, D
关键词Schizophrenia Single Nucleotide Polymorphism (Snp) Neuregulin 1(Nrg1) The Transmission Disequilibrium Test (Tdt) Haplotype
刊名MOLECULAR PSYCHIATRY
2003
DOI10.1038/sj.mp.4001377
8期:7页:706-709
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences ; Psychiatry
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry
关键词[WOS]SUSCEPTIBILITY ; SYNAPSES ; LINKAGE ; 8P
英文摘要

A number of studies have indicated that 8p22-p12 is likely to harbor schizophrenia susceptibility loci. In this region, the candidate gene of interest, neuregulin 1 (NRG1), may play a role in the pathogenesis of schizophrenia. Then in the present study, we performed the linkage disequilibrium to determine the association between three genetic variants (SNPs: rs3924999, rs2954041, SNP8NRG221533) on NRG1 gene and schizophrenia in 246 Chinese Han schizophrenic family trios using PCR-based restriction fragment length polymorphism method and denaturing high-performance liquid chromatography. The transmission disequilibrium test analysis for each variant showed a significant difference between two transmitted alleles even after Bonferroni correction (rs3924999, P=0.007752; rs2954041, P=0.0009309; SNP8NRG221533, P=0.012606). The global chi(2) test for haplotype transmission also revealed a strong association (chi(2)=46.068, df=7, P<0.000001). Our results suggest that the NRG1 gene may play a role in conferring susceptibility to the disease.

语种英语
WOS记录号WOS:000184427800010
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被引频次:176[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58077
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Jilin Univ, Ctr Genom Med, Changchun 130021, Peoples R China
3.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
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GB/T 7714
Yang, JZ,Si, TM,Ruan, Y,et al. Association study of neuregulin 1 gene with schizophrenia[J]. MOLECULAR PSYCHIATRY,2003,8(7):706-709.
APA Yang, JZ.,Si, TM.,Ruan, Y.,Ling, YS.,Han, YH.,...&Zhang, D.(2003).Association study of neuregulin 1 gene with schizophrenia.MOLECULAR PSYCHIATRY,8(7),706-709.
MLA Yang, JZ,et al."Association study of neuregulin 1 gene with schizophrenia".MOLECULAR PSYCHIATRY 8.7(2003):706-709.
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