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学科主题: 精神卫生
题名:
Association study of neuregulin 1 gene with schizophrenia
作者: Yang, JZ; Si, TM; Ruan, Y; Ling, YS; Han, YH; Wang, XL; Zhou, M; Zhang, HY; Kong, QM; Liu, C; Zhang, DR; Yu, YQ; Liu, SZ; Ju, GZ; Shu, L; Ma, DL; Zhang, D
关键词: schizophrenia ; single nucleotide polymorphism (SNP) ; neuregulin 1(NRG1) ; the transmission disequilibrium test (TDT) ; haplotype
刊名: MOLECULAR PSYCHIATRY
发表日期: 2003
DOI: 10.1038/sj.mp.4001377
卷: 8, 期:7, 页:706-709
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences ; Psychiatry
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry
关键词[WOS]: SUSCEPTIBILITY ; SYNAPSES ; LINKAGE ; 8P
英文摘要:

A number of studies have indicated that 8p22-p12 is likely to harbor schizophrenia susceptibility loci. In this region, the candidate gene of interest, neuregulin 1 (NRG1), may play a role in the pathogenesis of schizophrenia. Then in the present study, we performed the linkage disequilibrium to determine the association between three genetic variants (SNPs: rs3924999, rs2954041, SNP8NRG221533) on NRG1 gene and schizophrenia in 246 Chinese Han schizophrenic family trios using PCR-based restriction fragment length polymorphism method and denaturing high-performance liquid chromatography. The transmission disequilibrium test analysis for each variant showed a significant difference between two transmitted alleles even after Bonferroni correction (rs3924999, P=0.007752; rs2954041, P=0.0009309; SNP8NRG221533, P=0.012606). The global chi(2) test for haplotype transmission also revealed a strong association (chi(2)=46.068, df=7, P<0.000001). Our results suggest that the NRG1 gene may play a role in conferring susceptibility to the disease.

语种: 英语
WOS记录号: WOS:000184427800010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58077
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Jilin Univ, Ctr Genom Med, Changchun 130021, Peoples R China
3.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China

Recommended Citation:
Yang, JZ,Si, TM,Ruan, Y,et al. Association study of neuregulin 1 gene with schizophrenia[J]. MOLECULAR PSYCHIATRY,2003,8(7):706-709.
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