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学科主题: 药学
题名:
Cardenolides from Saussurea stella with cytotoxicity toward cancer cells
作者: Wang, Tian-Min; Hojo, Toshinari; Ran, Fu-Xiang; Wang, Ru-Feng; Wang, Rui-Qing; Chen, Hu-Biao; Cui, Jing-Rong; Shang, Ming-Ying; Cai, Shao-Qing
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2007-09-01
DOI: 10.1021/np070150o
卷: 70, 期:9, 页:1429-1433
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: GLYKOSIDE UND AGLYKONE ; CARDIAC-GLYCOSIDES ; LOPHOPETALUM-TOXICUM ; DIE GLYKOSIDE ; ARROW POISON
英文摘要:

Three new cardenolides, 3-O-beta-D-fucopyranosylstrophanthidin (1), 3-O-beta-D-quinovopyranosylperiplogenin (2), and 3-O-beta-D-glucopyranosyl-(1 -> 4)-alpha-L-rhamnopyranosylcannogenin (3), together with seven known cardenolides (4-10), were isolated from a cytotoxic ethanol extract of the whole dried plants of Saussurea stella. The structures of these compounds were established by spectroscopic and chemical methods. When the cytotoxicity of compounds 2-10 toward Bel-7402 human hepatoma cells and BGC-823 human gastric cancer cells was evaluated, all compounds showed IC50 values of <1 mu M for both cell lines. This is the first report of cardenolides occurring in a species of the family Asteraceae.

语种: 英语
WOS记录号: WOS:000249871200007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58082
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.ARSOA Honsha Corp ARSOA R&D Ctr, Yamanashi, Japan
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
3.Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Wang, Tian-Min,Hojo, Toshinari,Ran, Fu-Xiang,et al. Cardenolides from Saussurea stella with cytotoxicity toward cancer cells[J]. JOURNAL OF NATURAL PRODUCTS,2007,70(9):1429-1433.
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