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Twelve-month follow-up detection of high-risk human papillomavirus (HPV) DNA for 93 cases with cervical intraepithelial neoplasia grade 2 or 3 (CIN 2-3) after a loop electrosurgical excisional procedure (LEEP)
Guo, H. Y.; Guo, Y. L.; You, K.; Geng, L.
关键词Loop Electrosurgical Excisional Procedure Human Papillomavirus Follow-up
刊名EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
2011
32期:2页:164-167
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Obstetrics & Gynecology
研究领域[WOS]Oncology ; Obstetrics & Gynecology
关键词[WOS]COLD KNIFE CONIZATION ; TRANSFORMATION ZONE ; NATURAL-HISTORY ; DISEASE ; DYSPLASIA ; MARGINS ; LESIONS
英文摘要

Purpose: The purpose of this study was to follow-up cervical intraepithelial neoplasia grades 2 or 3 (CIN2/3) cases after a loop electrosurgical excisional procedure (LEEP) by liquid-based cytology (LBC) and detection of HPV DNA. Methods: LEEP was performed for the first diagnosed CIN2/3 cases. Six and 12 months after LEEP, LBC and HPV DNA detection were performed. Results: The number of cases with CIN2 accounted for 64.5% (60/93) of the total cases before LEEP. Six months post LEEP, the number of cases with normal LBC and negative HPV DNA accounted for 63.4% (59/93). Cases with abnormal LBC accounted for 17.2 (16/93), and cases with persistent positive HPV DNA accounted for 11.8% (7/93). Two cases had both persistent positive HPV DNA and abnormal LBC. A vaginal intraepithelial neoplasm (VAIN2) was found in one of the HPV DNA persistent positive cases. Twelve months post LEEP, 4.3% (8/93) of the cases were HPV DNA positive. Abnormal LBC was observed in four cases (of which 2 cases were HPV DNA positive) with normal LBC and negative HPV DNA at six months post LEEP. Conclusion: HPV DNA examination is instrumental for the detection of VAIN.

语种英语
WOS记录号WOS:000289188000010
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58083
专题北京大学第三临床医学院
北京大学第三临床医学院_妇产科
作者单位Peking Univ, Hosp 3, Dept Obstet & Gynaecol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Guo, H. Y.,Guo, Y. L.,You, K.,et al. Twelve-month follow-up detection of high-risk human papillomavirus (HPV) DNA for 93 cases with cervical intraepithelial neoplasia grade 2 or 3 (CIN 2-3) after a loop electrosurgical excisional procedure (LEEP)[J]. EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY,2011,32(2):164-167.
APA Guo, H. Y.,Guo, Y. L.,You, K.,&Geng, L..(2011).Twelve-month follow-up detection of high-risk human papillomavirus (HPV) DNA for 93 cases with cervical intraepithelial neoplasia grade 2 or 3 (CIN 2-3) after a loop electrosurgical excisional procedure (LEEP).EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY,32(2),164-167.
MLA Guo, H. Y.,et al."Twelve-month follow-up detection of high-risk human papillomavirus (HPV) DNA for 93 cases with cervical intraepithelial neoplasia grade 2 or 3 (CIN 2-3) after a loop electrosurgical excisional procedure (LEEP)".EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY 32.2(2011):164-167.
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