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Translocation chromosome karyotypes of the Robertsonian translocation carriers′ embryos
Jin, Huang; Ping, Liu; Jie, Qiao; Ying, Lian; Chen Yongjian
关键词Preimplantation Genetic Diagnosis Robertsonian Translocation Alternate Adjacent Meiotic Division
刊名FERTILITY AND STERILITY
2010-03-01
DOI10.1016/j.fertnstert.2008.11.020
93期:4页:1061-1065
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]MEIOTIC SEGREGATION PATTERNS ; SPERM ; FISH ; ABNORMALITIES ; ASSOCIATION ; ANEUPLOIDY ; MOSAICISM ; TRIVALENT ; REVEALS ; NUCLEI
英文摘要

Objective: To explore the translocation karyotypes of the Robertsonian translocation (RT) carriers′ embryos in their preimplantation genetic diagnosis (PGD) cycles.

Design: Retrospective.

Setting: University-affiliated IVF center.

Patient(s): A total of 35 RT carrier Couples underwent 39 blastomere PGD cycles from August 2005 to June 2008.

Intervention(S): The PGD analysis of embryos.

Main Outcome Measure(s): Meiotic segregation patterns of the 253 embryos were analyzed in their PGD cycles.

Result(s): The alternate embryos were approximately one third of all the embryos (82 of 253, 32.41%). The ratio 14 among the alternate embryos, the adjacent-1 embryos and the adjacent-2 embryos was 2:1:1. There was no significant difference between the male RT Subgroup and the female RT subgroup (31.43% vs. 37.21%) regarding the proportion of the alternate embryos and no significant difference was found between the common RT subgroup and the rare RT subgroup (33.48% vs. 25.00%). In contrast, the alternate embryo percentage in the pregnancy subgroup was much higher than that of the pregnancy failure subgroup (45.16% vs. 28.27%).

Conclusion(S): The alternate embryos are dominant among the RT carriers′ embryos and different gender and different translocation chromosomes have no effect on the alternate embryos rate. The ratio among the alternate embryos, the adjacent-1 embryos and the adjacent-2 embryos is 2:1:1. (Fertil Steril (R) 2010;93:1061-5. (C)2010 by American Society for Reproductive Medicine.)

语种英语
WOS记录号WOS:000275541000006
项目编号2007ZB948102
资助机构Nation Basic Research Program of China
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58087
专题北京大学第三临床医学院_生殖医学中心
作者单位Peking Univ, Hosp 3, Ctr Reprod Med, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Jin, Huang,Ping, Liu,Jie, Qiao,et al. Translocation chromosome karyotypes of the Robertsonian translocation carriers′ embryos[J]. FERTILITY AND STERILITY,2010,93(4):1061-1065.
APA Jin, Huang,Ping, Liu,Jie, Qiao,Ying, Lian,&Chen Yongjian.(2010).Translocation chromosome karyotypes of the Robertsonian translocation carriers′ embryos.FERTILITY AND STERILITY,93(4),1061-1065.
MLA Jin, Huang,et al."Translocation chromosome karyotypes of the Robertsonian translocation carriers′ embryos".FERTILITY AND STERILITY 93.4(2010):1061-1065.
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