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学科主题: 临床医学
题名:
Translocation chromosome karyotypes of the Robertsonian translocation carriers′ embryos
作者: Jin, Huang; Ping, Liu; Jie, Qiao; Ying, Lian; Chen Yongjian
关键词: Preimplantation genetic diagnosis ; Robertsonian translocation ; alternate ; adjacent ; meiotic division
刊名: FERTILITY AND STERILITY
发表日期: 2010-03-01
DOI: 10.1016/j.fertnstert.2008.11.020
卷: 93, 期:4, 页:1061-1065
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]: Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]: MEIOTIC SEGREGATION PATTERNS ; SPERM ; FISH ; ABNORMALITIES ; ASSOCIATION ; ANEUPLOIDY ; MOSAICISM ; TRIVALENT ; REVEALS ; NUCLEI
英文摘要:

Objective: To explore the translocation karyotypes of the Robertsonian translocation (RT) carriers′ embryos in their preimplantation genetic diagnosis (PGD) cycles.

Design: Retrospective.

Setting: University-affiliated IVF center.

Patient(s): A total of 35 RT carrier Couples underwent 39 blastomere PGD cycles from August 2005 to June 2008.

Intervention(S): The PGD analysis of embryos.

Main Outcome Measure(s): Meiotic segregation patterns of the 253 embryos were analyzed in their PGD cycles.

Result(s): The alternate embryos were approximately one third of all the embryos (82 of 253, 32.41%). The ratio 14 among the alternate embryos, the adjacent-1 embryos and the adjacent-2 embryos was 2:1:1. There was no significant difference between the male RT Subgroup and the female RT subgroup (31.43% vs. 37.21%) regarding the proportion of the alternate embryos and no significant difference was found between the common RT subgroup and the rare RT subgroup (33.48% vs. 25.00%). In contrast, the alternate embryo percentage in the pregnancy subgroup was much higher than that of the pregnancy failure subgroup (45.16% vs. 28.27%).

Conclusion(S): The alternate embryos are dominant among the RT carriers′ embryos and different gender and different translocation chromosomes have no effect on the alternate embryos rate. The ratio among the alternate embryos, the adjacent-1 embryos and the adjacent-2 embryos is 2:1:1. (Fertil Steril (R) 2010;93:1061-5. (C)2010 by American Society for Reproductive Medicine.)

语种: 英语
所属项目编号: 2007ZB948102
项目资助者: Nation Basic Research Program of China
WOS记录号: WOS:000275541000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58087
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: Peking Univ, Hosp 3, Ctr Reprod Med, Beijing 100191, Peoples R China

Recommended Citation:
Jin, Huang,Ping, Liu,Jie, Qiao,et al. Translocation chromosome karyotypes of the Robertsonian translocation carriers′ embryos[J]. FERTILITY AND STERILITY,2010,93(4):1061-1065.
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