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学科主题: 临床医学
题名:
Endogenous Hydrogen Sulfide Regulates Pulmonary Artery Collagen Remodeling in Rats with High Pulmonary Blood Flow
作者: Li, Xiaohui1,2; Jin, Hongfang1,2; Bin, Geng3; Wang, Li4; Tang, Chaoshu3; Du, Junbao1,2
关键词: hydrogen sulfide ; collagen ; pulmonary artery ; inhibitor of metalloproteinase-1 (TIMP-1) ; matrix metalloproteinase-13 (MMP-13)
刊名: EXPERIMENTAL BIOLOGY AND MEDICINE
发表日期: 2009-05-01
DOI: 10.3181/0807-RM-230
卷: 234, 期:5, 页:504-512
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: PROPARGYLGLYCINE ; INACTIVATION ; HYPERTENSION ; PATHOGENESIS ; FIBROBLASTS ; H2S
英文摘要:

The mechanisms responsible for the structural remodeling of pulmonary vasculature induced by increased pulmonary blood flow are not fully understood. This study explores the effect of endogenous hydrogen sulfide (H(2)S), a novel gasotransmitter, on collagen remodeling of the pulmonary artery in rats with high pulmonary blood flow. Thirty-two Sprague-Dawley rats were randomly divided into sham, shunt, sham+PPG (D,L-propargylglycine, an inhibitor of cystathionine-gamma-lyase), and shunt+PPG groups. After 4 weeks of shunting, the relative medial thickness (RMT) of pulmonary arteries and H(2)S concentration in lung tissues were investigated. Collagen I and collagen III were evaluated by hydroxyproline assay, sirius-red staining, and immunohistochemistry. Pulmonary artery matrix metalloproteinase-13 (MMP-13), tissue inhibitor of metalloproteinase-1 (TIMP-1), and connective tissue growth factor (CTGF) were evaluated by immunohistochemistry. After 4 weeks of aortocaval shunting, resulting in an elevation of lung tissue H(2)S to 116.4%, rats exhibited collagen remodeling and increased CTGF expression in the pulmonary arteries. Compared with those of the shunt group, lung tissue H(2)S production was lowered by 23.4%, RMT of the pulmonary artery further increased by 39.5%, pulmonary artery collagen accumulation became obvious, and pulmonary artery CTGF expression elevated (P < 0.01) in the shunted rats treated with PPG. However, pulmonary artery MMP-13 and TIMP-1 expressions decreased significantly in rats of shunt+PPG group (P < 0.01). This study suggests that endogenous H(2)S exerts an important regulatory effect on pulmonary collagen remodeling induced by high pulmonary blood flow. Exp Biol Med 234:504-512, 2009

语种: 英语
所属项目编号: 7072087 ; 30425010 ; 30821001 ; 30801251 ; 30630031 ; 30872787
项目资助者: Natural Science Foundation of Beijing. P. R. China ; National Natural Science Foundation of China
WOS记录号: WOS:000265626800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58092
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Minist Educ, Kev Lab Mol Cardiovasc Sci, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100034, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Sci Res, Beijing 100034, Peoples R China

Recommended Citation:
Li, Xiaohui,Jin, Hongfang,Bin, Geng,et al. Endogenous Hydrogen Sulfide Regulates Pulmonary Artery Collagen Remodeling in Rats with High Pulmonary Blood Flow[J]. EXPERIMENTAL BIOLOGY AND MEDICINE,2009,234(5):504-512.
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