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学科主题口腔医学
Two cases of multiple ossifying fibromas in the jaws
Wang, Ting-Ting1; Zhang, Ran2; Wang, Lin1; Chen, Yan2; Dong, Qing1; Li, Tie-Jun2,3,4
关键词Multiple Ossifying Fibroma Hpt-jt Fibrous Dysplasia Gnas Gene Hrpt2 Gene Osseous Dysplasia
刊名DIAGNOSTIC PATHOLOGY
2014-03-28
DOI10.1186/1746-1596-9-75
9
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]CEMENTO-OSSEOUS DYSPLASIA ; BENIGN FIBROOSSEOUS LESIONS ; GERMLINE HRPT2 MUTATIONS ; OF-THE-LITERATURE ; TUMOR SYNDROME ; FAMILIAL HYPERPARATHYROIDISM ; HEREDITARY HYPERPARATHYROIDISM ; PARATHYROID CARCINOMA ; FOLLOW-UP ; MAXILLARY SINUS
英文摘要

Background: The clinicopathologic characteristics of multiple ossifying fibroma (OF) are unclear due to the condition′s rarity, making diagnosis challenging. Sporadic multiple OFs must be distinguished from hyperparathyroidism-jaw tumour syndrome (HPT-JT) related OF and other fibro-osseous lesions.

Methods: Multiple OF cases were identified from ossifying fibroma cases. Clinical data including age, sex, anatomic site, radiographic features, clinical impression, treatment and available follow-up data as well as serum calcium, phosphorus, and parathyroid hormone (PTH) were recorded. GNAS and HRPT2 genetic mutations were examined in the two present cases. Case reports of sporadic multiple ossifying fibroma and HPT-JT-related OF were also reviewed.

Results: The two present cases were confirmed as sporadic multiple OF, with no genetic GNAS and HRPT2 mutations found. The incidence of sporadic multiple ossifying fibroma was 2.0% (2/102). The total 18 sporadic multiform OF cases were characterized as followed: 13 (72.2%) female; 5 (27.8%) male; mean age 28.6 years; 2/16 (11.1%) cases only in the mandible; 4/18 (22.2%) cases only in the maxilla; and 12/18 (66.7%) cases in both the maxilla and mandible. Radiographically, the lesions were radiolucent in 5/18 (27.8%) cases and mixed density in 13/18 (72.2%) cases. Along with 24 cases of HPT-JT related OF were reviewed, sixteen (66.7%) patients were diagnosed with a single lesion, and 8 patients (33.3%) were diagnosed with multiple jaw lesions.

Conclusions: Sporadic multiple OFs are very rare, but must be distinguished from HPT-JT related OF. We strongly recommend that patients diagnosed with multiple ossifying fibromas receive serum PTH testing and mutation screening of HRPT2.

Virtual slides: http://www.diagnosticpathology.diagnomx.eu/vs/1194507146115753

语种英语
WOS记录号WOS:000334617700001
项目编号81141092 ; 81030018 ; 81302349
资助机构National Natural Science Foundation of China
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58103
专题北京大学口腔医学院_口腔病理科
作者单位1.Natl Engn Lab Digital & Mat Technol Stomatol, Beijing, Peoples R China
2.Hebei United Univ, Sch & Hosp Stomatol, Dept Oral Med, Tangshan 063000, Hebei, Peoples R China
3.Peking Univ, Dept Oral Pathol, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
4.Peking Univ, Cent Lab, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Wang, Ting-Ting,Zhang, Ran,Wang, Lin,et al. Two cases of multiple ossifying fibromas in the jaws[J]. DIAGNOSTIC PATHOLOGY,2014,9.
APA Wang, Ting-Ting,Zhang, Ran,Wang, Lin,Chen, Yan,Dong, Qing,&Li, Tie-Jun.(2014).Two cases of multiple ossifying fibromas in the jaws.DIAGNOSTIC PATHOLOGY,9.
MLA Wang, Ting-Ting,et al."Two cases of multiple ossifying fibromas in the jaws".DIAGNOSTIC PATHOLOGY 9(2014).
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