北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学口腔医学院  > 口腔病理科  > 期刊论文
学科主题: 口腔医学
题名:
Two cases of multiple ossifying fibromas in the jaws
作者: Wang, Ting-Ting1; Zhang, Ran2; Wang, Lin1; Chen, Yan2; Dong, Qing1; Li, Tie-Jun2,3,4
关键词: Multiple ossifying fibroma ; HPT-JT ; Fibrous dysplasia ; GNAS gene ; HRPT2 gene ; Osseous dysplasia
刊名: DIAGNOSTIC PATHOLOGY
发表日期: 2014-03-28
DOI: 10.1186/1746-1596-9-75
卷: 9
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: CEMENTO-OSSEOUS DYSPLASIA ; BENIGN FIBROOSSEOUS LESIONS ; GERMLINE HRPT2 MUTATIONS ; OF-THE-LITERATURE ; TUMOR SYNDROME ; FAMILIAL HYPERPARATHYROIDISM ; HEREDITARY HYPERPARATHYROIDISM ; PARATHYROID CARCINOMA ; FOLLOW-UP ; MAXILLARY SINUS
英文摘要:

Background: The clinicopathologic characteristics of multiple ossifying fibroma (OF) are unclear due to the condition′s rarity, making diagnosis challenging. Sporadic multiple OFs must be distinguished from hyperparathyroidism-jaw tumour syndrome (HPT-JT) related OF and other fibro-osseous lesions.

Methods: Multiple OF cases were identified from ossifying fibroma cases. Clinical data including age, sex, anatomic site, radiographic features, clinical impression, treatment and available follow-up data as well as serum calcium, phosphorus, and parathyroid hormone (PTH) were recorded. GNAS and HRPT2 genetic mutations were examined in the two present cases. Case reports of sporadic multiple ossifying fibroma and HPT-JT-related OF were also reviewed.

Results: The two present cases were confirmed as sporadic multiple OF, with no genetic GNAS and HRPT2 mutations found. The incidence of sporadic multiple ossifying fibroma was 2.0% (2/102). The total 18 sporadic multiform OF cases were characterized as followed: 13 (72.2%) female; 5 (27.8%) male; mean age 28.6 years; 2/16 (11.1%) cases only in the mandible; 4/18 (22.2%) cases only in the maxilla; and 12/18 (66.7%) cases in both the maxilla and mandible. Radiographically, the lesions were radiolucent in 5/18 (27.8%) cases and mixed density in 13/18 (72.2%) cases. Along with 24 cases of HPT-JT related OF were reviewed, sixteen (66.7%) patients were diagnosed with a single lesion, and 8 patients (33.3%) were diagnosed with multiple jaw lesions.

Conclusions: Sporadic multiple OFs are very rare, but must be distinguished from HPT-JT related OF. We strongly recommend that patients diagnosed with multiple ossifying fibromas receive serum PTH testing and mutation screening of HRPT2.

Virtual slides: http://www.diagnosticpathology.diagnomx.eu/vs/1194507146115753

语种: 英语
所属项目编号: 81141092 ; 81030018 ; 81302349
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000334617700001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58103
Appears in Collections:北京大学口腔医学院_口腔病理科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Natl Engn Lab Digital & Mat Technol Stomatol, Beijing, Peoples R China
2.Hebei United Univ, Sch & Hosp Stomatol, Dept Oral Med, Tangshan 063000, Hebei, Peoples R China
3.Peking Univ, Dept Oral Pathol, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
4.Peking Univ, Cent Lab, Sch & Hosp Stomatol, Beijing 100081, Peoples R China

Recommended Citation:
Wang, Ting-Ting,Zhang, Ran,Wang, Lin,et al. Two cases of multiple ossifying fibromas in the jaws[J]. DIAGNOSTIC PATHOLOGY,2014,9.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Ting-Ting]'s Articles
[Zhang, Ran]'s Articles
[Wang, Lin]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Ting-Ting]‘s Articles
[Zhang, Ran]‘s Articles
[Wang, Lin]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace