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学科主题: 基础医学
题名:
The spleen as a target in severe acute respiratory syndrome
作者: Zhan, Jun; Deng, Ruishu; Tang, Junmin; Zhang, Bo; Tang, Yan; Wang, Jeffrey K.; Li, Feng; Anderson, Virginia M.; McNutt, Michael A.; Gu, Jiang
关键词: immunodeficiency ; T lymphocytes ; B lymphocytes ; SARS
刊名: FASEB JOURNAL
发表日期: 2006-11-01
DOI: 10.1096/fj.06-6324com
卷: 20, 期:13, 页:2321-2328
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
关键词[WOS]: A H5N1 VIRUS ; SARS-CORONAVIRUS ; DENDRITIC CELLS ; HUMAN-DISEASE ; INFECTION ; IDENTIFICATION ; PATHOGENESIS ; MACROPHAGES ; CYTOKINES ; PATHOLOGY
英文摘要:

It has been proposed that immune injury is the central mechanism of pathogenesis of the infectious disease, severe acute respiratory syndrome (SARS). To gain a better understanding of immune injury in the spleen, we investigated the number and distribution of various immune cell types in the spleens of SARS patients. We performed autopsies on six confirmed SARS cases, with six normal subjects as controls; spleen samples from these autopsies were examined with hematoxylin and eosin (H&E) sections, in situ hybridization for SARS virus genomic sequences, and immunohistochemistry with seven monoclonal antibodies to five cell types. The number and distribution of these cells were measured and analyzed using an image analysis system. SARS genomic sequences were detected in all SARS spleens. The SARS spleens all had severe damage to the white pulp and showed an alteration of the normal distribution of various cell types. Immunocytes in the red pulp were decreased by 68.0-90.7% except for CD68(+) macrophages and human leukocyte antigen (HLA)-DR positive antigen-presenting cells (APC), which were decreased to a lesser degree. On average, CD68(+) macrophages were increased in size by 2.21-fold. We hypothesize that the collapse of the splenic immune system plays a key role in the clinical outcome of these patients.

语种: 英语
WOS记录号: WOS:000241702600017
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58104
Appears in Collections:基础医学院_北京大学感染病研究中心_期刊论文

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作者单位: 1.Univ So Calif, Keck Sch Med, Los Angeles, CA USA
2.Peking Univ, Ctr Infect Dis, Sch Basic Med Sci, Dept Pathol,Hlth Sci Ctr, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Histol & Embryol, Beijing 100083, Peoples R China
4.SUNY Hlth Sci Ctr Brooklyn, Dept Pathol, Brooklyn, NY USA

Recommended Citation:
Zhan, Jun,Deng, Ruishu,Tang, Junmin,et al. The spleen as a target in severe acute respiratory syndrome[J]. FASEB JOURNAL,2006,20(13):2321-2328.
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