学科主题基础医学
The spleen as a target in severe acute respiratory syndrome
Zhan, Jun; Deng, Ruishu; Tang, Junmin; Zhang, Bo; Tang, Yan; Wang, Jeffrey K.; Li, Feng; Anderson, Virginia M.; McNutt, Michael A.; Gu, Jiang
关键词immunodeficiency T lymphocytes B lymphocytes SARS
刊名FASEB JOURNAL
2006-11-01
DOI10.1096/fj.06-6324com
20期:13页:2321-2328
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
关键词[WOS]A H5N1 VIRUS ; SARS-CORONAVIRUS ; DENDRITIC CELLS ; HUMAN-DISEASE ; INFECTION ; IDENTIFICATION ; PATHOGENESIS ; MACROPHAGES ; CYTOKINES ; PATHOLOGY
英文摘要

It has been proposed that immune injury is the central mechanism of pathogenesis of the infectious disease, severe acute respiratory syndrome (SARS). To gain a better understanding of immune injury in the spleen, we investigated the number and distribution of various immune cell types in the spleens of SARS patients. We performed autopsies on six confirmed SARS cases, with six normal subjects as controls; spleen samples from these autopsies were examined with hematoxylin and eosin (H&E) sections, in situ hybridization for SARS virus genomic sequences, and immunohistochemistry with seven monoclonal antibodies to five cell types. The number and distribution of these cells were measured and analyzed using an image analysis system. SARS genomic sequences were detected in all SARS spleens. The SARS spleens all had severe damage to the white pulp and showed an alteration of the normal distribution of various cell types. Immunocytes in the red pulp were decreased by 68.0-90.7% except for CD68(+) macrophages and human leukocyte antigen (HLA)-DR positive antigen-presenting cells (APC), which were decreased to a lesser degree. On average, CD68(+) macrophages were increased in size by 2.21-fold. We hypothesize that the collapse of the splenic immune system plays a key role in the clinical outcome of these patients.

语种英语
WOS记录号WOS:000241702600017
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58104
专题北京大学基础医学院_北京大学感染病研究中心
作者单位1.Univ So Calif, Keck Sch Med, Los Angeles, CA USA
2.Peking Univ, Ctr Infect Dis, Sch Basic Med Sci, Dept Pathol,Hlth Sci Ctr, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Histol & Embryol, Beijing 100083, Peoples R China
4.SUNY Hlth Sci Ctr Brooklyn, Dept Pathol, Brooklyn, NY USA
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GB/T 7714
Zhan, Jun,Deng, Ruishu,Tang, Junmin,et al. The spleen as a target in severe acute respiratory syndrome[J]. FASEB JOURNAL,2006,20(13):2321-2328.
APA Zhan, Jun.,Deng, Ruishu.,Tang, Junmin.,Zhang, Bo.,Tang, Yan.,...&Gu, Jiang.(2006).The spleen as a target in severe acute respiratory syndrome.FASEB JOURNAL,20(13),2321-2328.
MLA Zhan, Jun,et al."The spleen as a target in severe acute respiratory syndrome".FASEB JOURNAL 20.13(2006):2321-2328.
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