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学科主题: 临床医学
题名:
Mesenchymal stem cells derived from different origins have unique sensitivities to different chemotherapeutic agents
作者: Qi, Zhengyu1,2; Zhang, Yanmin1,2; Liu, Lin3; Guo, Xin1,2; Qin, Jie1,2; Cui, Guanghui1,2
关键词: adipose-tissue-derived mesenchymal stem cell ; apoptosis ; bone-marrow-derived mesenchymal stem cell ; chemosensitivity ; proliferation ; senescence
刊名: CELL BIOLOGY INTERNATIONAL
发表日期: 2012-09-01
DOI: 10.1042/CBI20110637
卷: 36, 期:9, 页:857-862
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: HUMAN ADIPOSE-TISSUE ; BONE-MARROW ; BUSULFAN ; PROTEIN ; KINASE
英文摘要:

BMSCs (bone-marrow-derived mesenchymal stem cells) and ADSCs (adipose tissue-derived mesenchymal stem cells) are virtually identical in cell surface marker profile and differentiation potential. These cell populations have promising characteristics for clinical application. We have investigated the sensitivity of these cell populations to various chemotherapeutic agents by testing the inhibition of cell proliferation, low molecular DNA bands formation, in situ apoptosis, apoptosis-related gene expression and cell senescence after treatment. BU (busulfan), methotrexate and doxorubicin treatment led to a marked and dose-dependent reduction in cell viability compared with 5-FU (5-fluorouracil) treatment. Different expression patterns of apoptosis-related genes were found in the BMSCs and ADSCs following treatment with the agents, but no low molecular mass DNA bands were detected. BMSCs had a higher percentage of apoptotic and senescent cells following treatment with chemotherapeutic agents compared with ADSCs. These findings suggest that these two cell populations respond differently to chemotherapy treatment. ADSCs are more resistant than BMSCs to chemotherapy-induced senescence and apoptosis, indicating that they might be more advantageous to use in the clinic than BMSCs.

语种: 英语
所属项目编号: 81070530 ; 201002070
项目资助者: China National Natural Science Foundation ; Shenzhen Science and Technology Project Foundation
WOS记录号: WOS:000308286000011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58106
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Peoples Hosp Donghai, Donghai 222300, Jiangsu, Peoples R China
2.Peking Univ, Shenzhen Hosp, Med Ctr, Guangdong Key Lab Male Reprod Med & Genet, Guangzhou 518036, Guangdong, Peoples R China
3.Hong Kong Univ Sci & Technol, Guangzhou 518036, Guangdong, Peoples R China

Recommended Citation:
Qi, Zhengyu,Zhang, Yanmin,Liu, Lin,et al. Mesenchymal stem cells derived from different origins have unique sensitivities to different chemotherapeutic agents[J]. CELL BIOLOGY INTERNATIONAL,2012,36(9):857-862.
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