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学科主题: 临床医学
题名:
Implications of transcriptional factor, OCT-4, in human bladder malignancy and tumor recurrence
作者: Huang, Peng1,2; Chen, Jie1,2; Wang, Lei1,2,3; Na, Yanqun3; Kaku, Haruki1,2; Ueki, Hideo1,2; Sasaki, Katsumi2; Yamaguchi, Ken1,2; Zhang, Kai4; Saika, Takashi2; Nasu, Yasutomo2; Watanabe, Masami1,2; Kumon, Hiromi1,2
关键词: OCT-4 ; Bladder cancer ; High grade ; Recurrence ; Immunostaining
刊名: MEDICAL ONCOLOGY
发表日期: 2012-06-01
DOI: 10.1007/s12032-011-9962-4
卷: 29, 期:2, 页:829-834
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CANCER STEM-CELLS ; EXPRESSION ; DIFFERENTIATION ; REIC/DKK-3
英文摘要:

OCT-4, which is also known as POU5f1, is a key regulator of self-renewal in embryonic stem cells. The new cancer stem cell concept proposes that the expression of such genes is potentially correlated with tumorigenesis and can affect some aspects of the cancer behavior, such as recurrence or metastasis. This study investigated the association between OCT-4 expression in cancer tissues obtained by transurethral surgery and the clinical data to clarify the involvement of OCT-4 in human bladder malignancy. Immunohistochemical analysis demonstrated that a positive rate of OCT-4 expression was significantly associated with the higher-grade cancer (G2 and G3) in comparison with that of the lower grade (G1). In addition, positive OCT-4 expression was significantly associated with the intra-bladder tumor recurrence after the operation. The staining intensity of OCT-4 expression was also correlated with tumor recurrence. These data indicate that positive OCT-4 expression may be involved in the development of high-grade bladder cancer and with the bladder cancer recurrence. This is the first study showing a correlation between the expression of OCT-4 and bladder cancer recurrence. OCT-4 may be a valuable clinical marker for the progression of bladder cancer and may be an attractive therapeutic target for the development of new medicines for the treatment of malignancy.

语种: 英语
项目资助者: Ministry of Education, Culture, Sports, Science and Technology in JAPAN
WOS记录号: WOS:000303539000068
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58107
Appears in Collections:北京大学第二临床医学院_泌尿外科_期刊论文

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作者单位: 1.Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Ctr Gene & Cell Therapy, Okayama 7008558, Japan
2.Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Urol, Okayama 7008558, Japan
3.Peking Univ, Peoples Hosp, Dept Urol, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 1, Inst Urol, Dept Urol, Beijing 100871, Peoples R China

Recommended Citation:
Huang, Peng,Chen, Jie,Wang, Lei,et al. Implications of transcriptional factor, OCT-4, in human bladder malignancy and tumor recurrence[J]. MEDICAL ONCOLOGY,2012,29(2):829-834.
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