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学科主题: 药学
题名:
ZnCl2-Promoted One-Pot Three-Component Synthesis of Multisubstituted Thiazolo[4,5-b]pyridines and Thieno[2,3-b:4,5-b ′]dipyridines
作者: Luo, Laichun; Meng, Lanlan; Peng, Yangqiu; Xing, Yongning; Sun, Qi; Ge, Zemei; Li, Runtao
关键词: Multicomponent reactions ; Polycycles ; Sulfur heterocycles ; Cyclization ; Synthetic methods
刊名: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
发表日期: 2015
DOI: 10.1002/ejoc.201403156
期: 3, 页:631-637
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: MULTICOMPONENT REACTIONS ; REGIOSELECTIVE SYNTHESIS ; MERCAPTONITRILE SALTS ; FRIEDLANDER REACTION ; DERIVATIVES ; INHIBITORS ; ANALOGS ; THIOPHENES ; THIAZOLES ; CHEMISTRY
英文摘要:

A ZnCl2-promoted one-pot synthesis of multisubstituted thiazolo[4,5-b]pyridines and thieno[2,3-b:4,5-b ′]dipyridines from mercaptonitrile salts, a-bromo ketones and ketones has been developed. This approach involves a tandem S(N)2 alkylation/Thorpe-Ziegler cyclization/Friedlander reaction, which allows the creation of two hetero rings and four new bonds in a single operation. The reaction proceeds smoothly under solvent-free conditions to afford fused pyridines in moderate to good yields.

语种: 英语
所属项目编号: NSFC 21272009
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000348436000023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58113
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Luo, Laichun,Meng, Lanlan,Peng, Yangqiu,et al. ZnCl2-Promoted One-Pot Three-Component Synthesis of Multisubstituted Thiazolo[4,5-b]pyridines and Thieno[2,3-b:4,5-b ′]dipyridines[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2015(3):631-637.
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