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ZnCl2-Promoted One-Pot Three-Component Synthesis of Multisubstituted Thiazolo[4,5-b]pyridines and Thieno[2,3-b:4,5-b ′]dipyridines
Luo, Laichun; Meng, Lanlan; Peng, Yangqiu; Xing, Yongning; Sun, Qi; Ge, Zemei; Li, Runtao
关键词Multicomponent Reactions Polycycles Sulfur Heterocycles Cyclization Synthetic Methods
刊名EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
2015
DOI10.1002/ejoc.201403156
3页:631-637
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]MULTICOMPONENT REACTIONS ; REGIOSELECTIVE SYNTHESIS ; MERCAPTONITRILE SALTS ; FRIEDLANDER REACTION ; DERIVATIVES ; INHIBITORS ; ANALOGS ; THIOPHENES ; THIAZOLES ; CHEMISTRY
英文摘要

A ZnCl2-promoted one-pot synthesis of multisubstituted thiazolo[4,5-b]pyridines and thieno[2,3-b:4,5-b ′]dipyridines from mercaptonitrile salts, a-bromo ketones and ketones has been developed. This approach involves a tandem S(N)2 alkylation/Thorpe-Ziegler cyclization/Friedlander reaction, which allows the creation of two hetero rings and four new bonds in a single operation. The reaction proceeds smoothly under solvent-free conditions to afford fused pyridines in moderate to good yields.

语种英语
WOS记录号WOS:000348436000023
项目编号NSFC 21272009
资助机构National Natural Science Foundation of China
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58113
专题北京大学药学院
北京大学药学院_化学生物学系
作者单位Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Luo, Laichun,Meng, Lanlan,Peng, Yangqiu,et al. ZnCl2-Promoted One-Pot Three-Component Synthesis of Multisubstituted Thiazolo[4,5-b]pyridines and Thieno[2,3-b:4,5-b ′]dipyridines[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2015(3):631-637.
APA Luo, Laichun.,Meng, Lanlan.,Peng, Yangqiu.,Xing, Yongning.,Sun, Qi.,...&Li, Runtao.(2015).ZnCl2-Promoted One-Pot Three-Component Synthesis of Multisubstituted Thiazolo[4,5-b]pyridines and Thieno[2,3-b:4,5-b ′]dipyridines.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(3),631-637.
MLA Luo, Laichun,et al."ZnCl2-Promoted One-Pot Three-Component Synthesis of Multisubstituted Thiazolo[4,5-b]pyridines and Thieno[2,3-b:4,5-b ′]dipyridines".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .3(2015):631-637.
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