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学科主题: 公共卫生
题名:
Effects of cod bone gelatin on bone metabolism and bone microarchitecture in ovariectomized rats
作者: Han, XiaoLong1; Xu, YaJun1; Wang, JunBo1; Pei, XinRong1; Yang, RuiYue1; Li, Ning2; Li, Yong1
关键词: Cod bone gelatin ; BMD ; Trabecular microarchitecture ; Osteoporosis ; Ovariectomy
刊名: BONE
发表日期: 2009-05-01
DOI: 10.1016/j.bone.2008.12.005
卷: 44, 期:5, 页:942-947
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: MICRO-COMPUTED TOMOGRAPHY ; INHIBITORY FACTOR OCIF ; CANCELLOUS BONE ; OSTEOCLAST DIFFERENTIATION ; POSTMENOPAUSAL WOMEN ; TRABECULAR BONE ; RANK LIGAND ; STRENGTH ; OSTEOPROTEGERIN ; RESORPTION
英文摘要:

Several animal studies have showed that gelatin may be effective for minimizing bone loss in OVX rats with established osteopenia. To gain insight into how cod bone gelatin administration affects bone loss after ovariectomy, Studies were carried out focusing on bone quality and the molecular mechanisms. Eighty-four female rats were ovariectomized, 12 sham-operated, divided into six groups of 12 each and treated one week after ovariectomy either with vehicle or cod bone gelatin (0.375, 0.75, 1.5, 3, 6 mg/kg body weight) for 90 days. Bone densitometry, mu CT analysis, real-time PCR analysis and biochemical analysis were used at the end of the Study. After 90 days, BMD of proximal tibia and femoral neck decreased in OVX rats, whereas the loss of BMD in those regions was prevented at 3 g/kg (P<0.05). However, the BMD of midshaft femurs showed no significant differences. BV/TV, Tb.N. and Tb.Th. in the 3 g/kg group were, respectively, 30.4% (P<0.05), 145.5% (P<0.05) and 81.5% (P<0.05) higher than in the OVX group. A significant decrease was detected in urine CTX, NTX and DPD, suggesting decreased bone resorption. Treatment with 3 g/kg and 6 g/kg cod bone gelatin attenuated the increase in serum IL-1 beta, IL-6 and TNF-alpha observed in the OVX group. Real-time PCR showed significantly decreased levels of mRNA expression for RANKL at the dosage of 6 g/kg and the RANKL/OPG mRNA ratio in the 3 g/kg and 6 g/kg group significantly decreased compared to the OVX group (P<0.05). In Conclusion, our data confirmed that the cod bone gelatin treatment at 3 g/kg is effective in the prevention of estrogen deficient bone loss by modulating the expression of RANKL and OPG and suppressing the release of proinflammatory cytokines. (C) 2008 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: C030103 ; 2006BAK02A07-6
项目资助者: National Natural Science Foundation of China ; National Key Technology RD Program
WOS记录号: WOS:000265436000028
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58115
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Dept Food Hyg & Nutr, Sch Publ Hlth, Beijing 100083, Peoples R China
2.Chinese Ctr Dis Prevent & Control, Natl Inst Nutr & Food Safety, Beijing 100050, Peoples R China

Recommended Citation:
Han, XiaoLong,Xu, YaJun,Wang, JunBo,et al. Effects of cod bone gelatin on bone metabolism and bone microarchitecture in ovariectomized rats[J]. BONE,2009,44(5):942-947.
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