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Effects of cod bone gelatin on bone metabolism and bone microarchitecture in ovariectomized rats
Han, XiaoLong1; Xu, YaJun1; Wang, JunBo1; Pei, XinRong1; Yang, RuiYue1; Li, Ning2; Li, Yong1
关键词Cod Bone Gelatin Bmd Trabecular Microarchitecture Osteoporosis Ovariectomy
刊名BONE
2009-05-01
DOI10.1016/j.bone.2008.12.005
44期:5页:942-947
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]MICRO-COMPUTED TOMOGRAPHY ; INHIBITORY FACTOR OCIF ; CANCELLOUS BONE ; OSTEOCLAST DIFFERENTIATION ; POSTMENOPAUSAL WOMEN ; TRABECULAR BONE ; RANK LIGAND ; STRENGTH ; OSTEOPROTEGERIN ; RESORPTION
英文摘要

Several animal studies have showed that gelatin may be effective for minimizing bone loss in OVX rats with established osteopenia. To gain insight into how cod bone gelatin administration affects bone loss after ovariectomy, Studies were carried out focusing on bone quality and the molecular mechanisms. Eighty-four female rats were ovariectomized, 12 sham-operated, divided into six groups of 12 each and treated one week after ovariectomy either with vehicle or cod bone gelatin (0.375, 0.75, 1.5, 3, 6 mg/kg body weight) for 90 days. Bone densitometry, mu CT analysis, real-time PCR analysis and biochemical analysis were used at the end of the Study. After 90 days, BMD of proximal tibia and femoral neck decreased in OVX rats, whereas the loss of BMD in those regions was prevented at 3 g/kg (P<0.05). However, the BMD of midshaft femurs showed no significant differences. BV/TV, Tb.N. and Tb.Th. in the 3 g/kg group were, respectively, 30.4% (P<0.05), 145.5% (P<0.05) and 81.5% (P<0.05) higher than in the OVX group. A significant decrease was detected in urine CTX, NTX and DPD, suggesting decreased bone resorption. Treatment with 3 g/kg and 6 g/kg cod bone gelatin attenuated the increase in serum IL-1 beta, IL-6 and TNF-alpha observed in the OVX group. Real-time PCR showed significantly decreased levels of mRNA expression for RANKL at the dosage of 6 g/kg and the RANKL/OPG mRNA ratio in the 3 g/kg and 6 g/kg group significantly decreased compared to the OVX group (P<0.05). In Conclusion, our data confirmed that the cod bone gelatin treatment at 3 g/kg is effective in the prevention of estrogen deficient bone loss by modulating the expression of RANKL and OPG and suppressing the release of proinflammatory cytokines. (C) 2008 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000265436000028
项目编号C030103 ; 2006BAK02A07-6
资助机构National Natural Science Foundation of China ; National Key Technology RD Program
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58115
专题北京大学公共卫生学院
北京大学公共卫生学院_营养与食品卫生学系
北京大学公共卫生学院_公共卫生学院
作者单位1.Peking Univ, Dept Food Hyg & Nutr, Sch Publ Hlth, Beijing 100083, Peoples R China
2.Chinese Ctr Dis Prevent & Control, Natl Inst Nutr & Food Safety, Beijing 100050, Peoples R China
推荐引用方式
GB/T 7714
Han, XiaoLong,Xu, YaJun,Wang, JunBo,et al. Effects of cod bone gelatin on bone metabolism and bone microarchitecture in ovariectomized rats[J]. BONE,2009,44(5):942-947.
APA Han, XiaoLong.,Xu, YaJun.,Wang, JunBo.,Pei, XinRong.,Yang, RuiYue.,...&Li, Yong.(2009).Effects of cod bone gelatin on bone metabolism and bone microarchitecture in ovariectomized rats.BONE,44(5),942-947.
MLA Han, XiaoLong,et al."Effects of cod bone gelatin on bone metabolism and bone microarchitecture in ovariectomized rats".BONE 44.5(2009):942-947.
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