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学科主题: 药学
题名:
In vitro and in vivo studies on plasma-to-blood ratio of paclitaxel in human, rabbit and rat blood fractions
作者: Liu, Xiang-Rui1; Wu, Ke-Chun1; Huang, Yue1; Sun, Jia-Bei1; Ke, Xi-Yu1; Wang, Jiang-Cheng1; Lu, Wan-Liang1,2; Zhang, Xuan1; Zhang, Qlang1,2
关键词: paclitaxel ; plasma-to-blood ratio ; blood fraction ; human ; rabbits ; rat
刊名: BIOLOGICAL & PHARMACEUTICAL BULLETIN
发表日期: 2008-06-01
卷: 31, 期:6, 页:1215-1220
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: HUMAN VOLUNTEER BLOOD ; CREMOPHOR EL ; FORMULATION VEHICLES ; UNBOUND PACLITAXEL ; PHARMACOKINETICS ; DISPOSITION ; PARTITION ; MICELLES ; BINDING ; TAXANE
英文摘要:

Many pharmacokinetic studies of paclitaxel formulations with or without Cremophor (CrEL) have been performed on experimental animals. However, limited studies describe the different pharmacokinetic behaviors of paclitaxel in animals. The different distribution of drug in blood fractions may have great effect on its pharmacokinctic behaviors. Our present study vas designed to study the characteristics of paclitaxel distribution in human, rabbit and rat blood, by measuring plasma-to-blood ratio (PBR) of paclitaxel in vitro and in vivo, and analyzing the results of equilibrium dialysis of paclitaxel with erythrocyte, plasma and hemoglobin. It vas demonstrated that the paclitaxel PBR values in rat, unlike those in rabbit, are most significantly different from those in human, which may be due to distinct affinity of paclitaxel to blood fractions among different species. The effect of CrEL on increasing paclitaxel plasma concentration and in vitro & in vivo correlation in animal PBR values were observed. The findings in this study are of significance in the evaluation of the newly developed formulations of paclitaxel.

语种: 英语
所属项目编号: 2004AA2Z3072 ; 30430760
项目资助者: High Technology Project of Ministry of Science and Technology of China ; National Natural Science Foundation of China
WOS记录号: WOS:000258634800030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58126
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Peking Univ, Dept Pharmaceut, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Liu, Xiang-Rui,Wu, Ke-Chun,Huang, Yue,et al. In vitro and in vivo studies on plasma-to-blood ratio of paclitaxel in human, rabbit and rat blood fractions[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2008,31(6):1215-1220.
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