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In vitro and in vivo studies on plasma-to-blood ratio of paclitaxel in human, rabbit and rat blood fractions
Liu, Xiang-Rui1; Wu, Ke-Chun1; Huang, Yue1; Sun, Jia-Bei1; Ke, Xi-Yu1; Wang, Jiang-Cheng1; Lu, Wan-Liang1,2; Zhang, Xuan1; Zhang, Qlang1,2
关键词Paclitaxel Plasma-to-blood Ratio Blood Fraction Human Rabbits Rat
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
2008-06-01
31期:6页:1215-1220
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]HUMAN VOLUNTEER BLOOD ; CREMOPHOR EL ; FORMULATION VEHICLES ; UNBOUND PACLITAXEL ; PHARMACOKINETICS ; DISPOSITION ; PARTITION ; MICELLES ; BINDING ; TAXANE
英文摘要

Many pharmacokinetic studies of paclitaxel formulations with or without Cremophor (CrEL) have been performed on experimental animals. However, limited studies describe the different pharmacokinetic behaviors of paclitaxel in animals. The different distribution of drug in blood fractions may have great effect on its pharmacokinctic behaviors. Our present study vas designed to study the characteristics of paclitaxel distribution in human, rabbit and rat blood, by measuring plasma-to-blood ratio (PBR) of paclitaxel in vitro and in vivo, and analyzing the results of equilibrium dialysis of paclitaxel with erythrocyte, plasma and hemoglobin. It vas demonstrated that the paclitaxel PBR values in rat, unlike those in rabbit, are most significantly different from those in human, which may be due to distinct affinity of paclitaxel to blood fractions among different species. The effect of CrEL on increasing paclitaxel plasma concentration and in vitro & in vivo correlation in animal PBR values were observed. The findings in this study are of significance in the evaluation of the newly developed formulations of paclitaxel.

语种英语
WOS记录号WOS:000258634800030
项目编号2004AA2Z3072 ; 30430760
资助机构High Technology Project of Ministry of Science and Technology of China ; National Natural Science Foundation of China
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58126
专题北京大学药学院_药剂学系
作者单位1.Peking Univ, Dept Pharmaceut, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Liu, Xiang-Rui,Wu, Ke-Chun,Huang, Yue,et al. In vitro and in vivo studies on plasma-to-blood ratio of paclitaxel in human, rabbit and rat blood fractions[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2008,31(6):1215-1220.
APA Liu, Xiang-Rui.,Wu, Ke-Chun.,Huang, Yue.,Sun, Jia-Bei.,Ke, Xi-Yu.,...&Zhang, Qlang.(2008).In vitro and in vivo studies on plasma-to-blood ratio of paclitaxel in human, rabbit and rat blood fractions.BIOLOGICAL & PHARMACEUTICAL BULLETIN,31(6),1215-1220.
MLA Liu, Xiang-Rui,et al."In vitro and in vivo studies on plasma-to-blood ratio of paclitaxel in human, rabbit and rat blood fractions".BIOLOGICAL & PHARMACEUTICAL BULLETIN 31.6(2008):1215-1220.
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