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学科主题: 临床医学
题名:
Patients receiving HLA-haploidentical/partially matched related allo-HSCT can achieve desirable health-related QoL that is comparable to that of patients receiving HLA-identical sibling allo-HSCT
作者: Mo, X-D; Xu, L-P; Liu, D-H; Chen, Y-H; Han, W.; Zhang, X-H; Chen, H.; Wang, Y.; Wang, J-Z; Liu, K-Y; Huang, X-J
关键词: health-related quality of life ; HLA-haploidentical ; partially matched related donor ; allogeneic hematopoietic SCT ; chronic GVHD
刊名: BONE MARROW TRANSPLANTATION
发表日期: 2012-09-01
DOI: 10.1038/bmt.2011.250
卷: 47, 期:9, 页:1201-1205
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]: VERSUS-HOST-DISEASE ; QUALITY-OF-LIFE ; BONE-MARROW-TRANSPLANTATION ; STEM-CELL TRANSPLANTATION ; ANTITHYMOCYTE GLOBULIN ; MYELOID-LEUKEMIA ; FOLLOW-UP ; SURVIVORS ; IMPACT ; PHYSICIANS
英文摘要:

To investigate the health-related quality of life (HRQoL) of patients receiving allogeneic hematopoietic SCT (allo-HSCT) from HLA-haploidentical/partially matched related donors (HID/PMRD) and to compare this value with that of patients receiving allo-HSCT from HLA-identical sibling donor (ISD), a total of 350 patients receiving allo-HSCT were enrolled in a study (ISD: 173; HID/PMRD: 177). HRQoL post transplantation was evaluated by an SF-36 questionnaire. The effect of various factors on the HRQoL was analyzed through COX regression. Compared with the ISD group, patients in the HID/PMRD group had higher scores in physical functioning, general health, bodily pain, vitality and emotional role functioning, and these patients functioned significantly better on the physical and mental component summaries. Also, long-term survivors exhibit better HRQoL. Measured by multivariate analysis, extensive chronic GVHD was observed to have a strongly negative impact on patients′ HRQoL, while male gender status, lower age when receiving allo-HSCT and returning to work or school were associated with positive impacts on at least one subscale. These results showed that the HRQoL of patients receiving HID/PMRD hematopoietic SCT (HSCT) is comparable to that of patients receiving ISD HSCT, and HLA disparity is not the factor affecting the HRQoL.

语种: 英语
所属项目编号: 30725038 ; IRT 0702
项目资助者: National Outstanding Young Scientist&prime ; s Foundation of China ; Program for Innovative Research Team in University
WOS记录号: WOS:000308343200010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58130
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China

Recommended Citation:
Mo, X-D,Xu, L-P,Liu, D-H,et al. Patients receiving HLA-haploidentical/partially matched related allo-HSCT can achieve desirable health-related QoL that is comparable to that of patients receiving HLA-identical sibling allo-HSCT[J]. BONE MARROW TRANSPLANTATION,2012,47(9):1201-1205.
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