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Patients receiving HLA-haploidentical/partially matched related allo-HSCT can achieve desirable health-related QoL that is comparable to that of patients receiving HLA-identical sibling allo-HSCT
Mo, X-D; Xu, L-P; Liu, D-H; Chen, Y-H; Han, W.; Zhang, X-H; Chen, H.; Wang, Y.; Wang, J-Z; Liu, K-Y; Huang, X-J
关键词Health-related Quality Of Life Hla-haploidentical Partially Matched Related Donor Allogeneic Hematopoietic Sct Chronic Gvhd
刊名BONE MARROW TRANSPLANTATION
2012-09-01
DOI10.1038/bmt.2011.250
47期:9页:1201-1205
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]VERSUS-HOST-DISEASE ; QUALITY-OF-LIFE ; BONE-MARROW-TRANSPLANTATION ; STEM-CELL TRANSPLANTATION ; ANTITHYMOCYTE GLOBULIN ; MYELOID-LEUKEMIA ; FOLLOW-UP ; SURVIVORS ; IMPACT ; PHYSICIANS
英文摘要

To investigate the health-related quality of life (HRQoL) of patients receiving allogeneic hematopoietic SCT (allo-HSCT) from HLA-haploidentical/partially matched related donors (HID/PMRD) and to compare this value with that of patients receiving allo-HSCT from HLA-identical sibling donor (ISD), a total of 350 patients receiving allo-HSCT were enrolled in a study (ISD: 173; HID/PMRD: 177). HRQoL post transplantation was evaluated by an SF-36 questionnaire. The effect of various factors on the HRQoL was analyzed through COX regression. Compared with the ISD group, patients in the HID/PMRD group had higher scores in physical functioning, general health, bodily pain, vitality and emotional role functioning, and these patients functioned significantly better on the physical and mental component summaries. Also, long-term survivors exhibit better HRQoL. Measured by multivariate analysis, extensive chronic GVHD was observed to have a strongly negative impact on patients′ HRQoL, while male gender status, lower age when receiving allo-HSCT and returning to work or school were associated with positive impacts on at least one subscale. These results showed that the HRQoL of patients receiving HID/PMRD hematopoietic SCT (HSCT) is comparable to that of patients receiving ISD HSCT, and HLA disparity is not the factor affecting the HRQoL.

语种英语
WOS记录号WOS:000308343200010
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58130
专题北京大学第二临床医学院_血液科
医学人文研究院/公共教学部_哲学与社会科学系
作者单位Peking Univ Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
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GB/T 7714
Mo, X-D,Xu, L-P,Liu, D-H,et al. Patients receiving HLA-haploidentical/partially matched related allo-HSCT can achieve desirable health-related QoL that is comparable to that of patients receiving HLA-identical sibling allo-HSCT[J]. BONE MARROW TRANSPLANTATION,2012,47(9):1201-1205.
APA Mo, X-D.,Xu, L-P.,Liu, D-H.,Chen, Y-H.,Han, W..,...&Huang, X-J.(2012).Patients receiving HLA-haploidentical/partially matched related allo-HSCT can achieve desirable health-related QoL that is comparable to that of patients receiving HLA-identical sibling allo-HSCT.BONE MARROW TRANSPLANTATION,47(9),1201-1205.
MLA Mo, X-D,et al."Patients receiving HLA-haploidentical/partially matched related allo-HSCT can achieve desirable health-related QoL that is comparable to that of patients receiving HLA-identical sibling allo-HSCT".BONE MARROW TRANSPLANTATION 47.9(2012):1201-1205.
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