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学科主题: 临床医学
题名:
Donor B Cells in Transplants Augment Clonal Expansion and Survival of Pathogenic CD4(+) T Cells That Mediate Autoimmune-like Chronic Graft-versus-Host Disease
作者: Young, James S.1,2,3; Wu, Tao1,3,4; Chen, Yuhong1,3,5; Zhao, Dongchang1,3; Liu, Hongjun1,3; Yi, Tangsheng1,2,3; Johnston, Heather1,2,3; Racine, Jeremy1,2,3; Li, Xiaofan1,3,6; Wang, Audrey7; Todorov, Ivan1; Zeng, Defu1,2,3
刊名: JOURNAL OF IMMUNOLOGY
发表日期: 2012-07-01
DOI: 10.4049/jimmunol.1200677
卷: 189, 期:1, 页:222-233
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: BONE-MARROW-TRANSPLANTATION ; ANTIGEN-PRESENTING CELLS ; CHRONIC GVHD ; STEM-CELLS ; IN-VIVO ; RITUXIMAB ; DEPLETION ; MEMORY ; SKIN ; RECONSTITUTION
英文摘要:

We reported that both donor CD4(+) T and B cells in transplants were required for induction of an autoimmune-like chronic graft-versus-host disease (cGVHD) in a murine model of DBA/2 donor to BALB/c recipient, but mechanisms whereby donor B cells augment cGVHD pathogenesis remain unknown. In this study, we report that, although donor B cells have little impact on acute GVHD severity, they play an important role in augmenting the persistence of tissue damage in the acute and chronic GVHD overlapping target organs (i.e., skin and lung); they also markedly augment damage in a prototypical cGVHD target organ, the salivary gland. During cGVHD pathogenesis, donor B cells are activated by donor CD4(+) T cells to upregulate MHC II and costimulatory molecules. Acting as efficient APCs, donor B cells augment donor CD4(+) T clonal expansion, autoreactivity, IL-7Ra expression, and survival. These qualitative changes markedly augment donor CD4(+) T cells′ capacity in mediating autoimmune-like cGVHD, so that they mediate disease in the absence of donor B cells in secondary recipients. Therefore, a major mechanism whereby donor B cells augment cGVHD is through augmenting the clonal expansion, differentiation, and survival of pathogenic CD4(+) T cells. The Journal of Immunology, 2012, 189: 222-233.

语种: 英语
WOS记录号: WOS:000305636000026
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58134
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.City Hope Natl Med Ctr, Beckman Res Inst, Dept Diabet Endocrinol, Duarte, CA 91010 USA
2.City Hope Natl Med Ctr, Irell & Manella Grad Sch Biol Sci, Duarte, CA 91010 USA
3.City Hope Natl Med Ctr, Beckman Res Inst, Dept Hematol & Hematopoiet Cell Transplantat, Duarte, CA 91010 USA
4.Second Mil Med Univ, Changhai Hosp, Dept Hematol, Shanghai 200433, Peoples R China
5.Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
6.Fujian Med Univ, Union Hosp, Fujian Inst Hematol, Dept Hematol, Fuzhou 350001, Peoples R China
7.City Hope Natl Med Ctr, Eugene & Ruth Roberts Summer Student Acad, Duarte, CA 91010 USA

Recommended Citation:
Young, James S.,Wu, Tao,Chen, Yuhong,et al. Donor B Cells in Transplants Augment Clonal Expansion and Survival of Pathogenic CD4(+) T Cells That Mediate Autoimmune-like Chronic Graft-versus-Host Disease[J]. JOURNAL OF IMMUNOLOGY,2012,189(1):222-233.
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