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学科主题: 临床医学
题名:
The role of contrast-enhanced ultrasound on the diagnosis of small hepatocellular carcinoma (<= 3 cm) in patients with cirrhosis
作者: Chen, Min Hua; Dai, Ying; Yan, Kun; Fan, Zhi Hui; Yin, Shan Shan; Yang, Wei; Wu, Wei; Wang, Yan Bin; Li, Ji You
关键词: ultrasound ; contrast agent ; cirrhosis ; hepatocellular carcinoma ; small lesion
刊名: HEPATOLOGY RESEARCH
发表日期: 2006-08-01
DOI: 10.1016/j.hepres.2006.04.013
卷: 35, 期:4, 页:281-288
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: FOCAL LIVER-LESIONS ; DYSPLASTIC NODULES ; HEPATIC-TUMORS ; AGENT ; ULTRASONOGRAPHY ; PATTERNS ; CT ; US
英文摘要:

Background: This study aimed to investigate the diagnostic value of contrast-enhanced ultrasound (CEUS) of small hepatocellular carcinomas (HCC) (<= 3cm) in patient with cirrhosis.

Materials and methods: Fifty-seven cases with 64 small HCC tumors (<= 3cm) were analyzed in this study. In these cases, all patients had liver cirrhosis and surgical or biopsy histopathological diagnosis. Diagnosis of baseline ultrasound (US) and CEUS of each lesion was made separately using a 5-point scoring system based on the US and CEUS characteristics of the lesions and was compared with histopathological results.

Results: All of the 47 moderately to poorly differentiated (MD-PD) HCC presented the "fast-in and fast-out" (FIFO) pattern with fast enhancement within 25 s and then a quick wash-out within 90 s after contrast injection. Ten of 17 well-differentiated (WD) HCC (58.8%) had "fast-in and slow-out" (FISO) pattern which washed out after 90 s and I WD HCC had "fast-in and no-out" (FINO) pattern which did not wash out till 360 s. Three well differentiated clear cell carcinomas smaller than 1.5 cm showed "slow-in and slow-out" (SISO) pattern which enhanced after 25 s and washed out after 90 s. On baseline US, only 36 lesions (56.3%) were diagnosed as definitely or possibly malignant lesions. After CEUS, 50 lesions (78.1%) with "FIFO" pattern were diagnosed as definitely malignant, while 15.6% (10 lesions) with "FISO" pattern as possibly malignant, only 4 lesions (6.3%) with "FINO" or "SISO" pattern could not be diagnosed by CEUS.

Conclusion: The typical enhancement patterns of "FIFO" or "FISO" of small HCC could improve the diagnostic ability of ultrasound in cirrhotic liver. Small HCC also had atypical enhancement patterns including "FINO" and "SISO". It shows that CEUS could be a useful imaging modality in small HCC diagnosis. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000240159300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58140
Appears in Collections:北京大学临床肿瘤学院_超声科_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Dept Ultrasound, Beijing 100036, Peoples R China
2.Peking Univ, Sch Oncol, Dept Pathol, Beijing 100036, Peoples R China

Recommended Citation:
Chen, Min Hua,Dai, Ying,Yan, Kun,et al. The role of contrast-enhanced ultrasound on the diagnosis of small hepatocellular carcinoma (&lt;= 3 cm) in patients with cirrhosis[J]. HEPATOLOGY RESEARCH,2006,35(4):281-288.
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