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Elevation of C-reactive protein and interleukin-6 in plasma of patients with aggressive periodontitis
Sun, X. J.; Meng, H. X.; Shi, D.; Xu, L.; Zhang, L.; Chen, Z. B.; Feng, X. H.; Lu, R. F.; Ren, X. Y.
关键词Aggressive Periodontitis C-reactive Proteins Interleukin-6
刊名JOURNAL OF PERIODONTAL RESEARCH
2009-06-01
DOI10.1111/j.1600-0765.2008.01131.x
44期:3页:311-316
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]CORONARY-HEART-DISEASE ; CARDIOVASCULAR-DISEASE ; INSULIN-RESISTANCE ; IN-VITRO ; RISK ; POPULATION ; GLUCOSE ; BLOOD ; ASSOCIATION ; PREVENTION
英文摘要

Systemic levels of C-reactive protein and interleukin-6 have been reported to be elevated in patients with periodontitis compared with periodontally healthy individuals. Most studies included patients with chronic periodontitis and comprised predominantly Caucasians. The aim of this study was to determine the relative levels of C-reactive protein and interleukin-6 in plasma of patients with aggressive periodontitis in China and to examine the relationships between these two inflammatory mediators and clinical parameters, peripheral blood cells and protein variables.

Plasma samples were collected from 84 patients with aggressive periodontitis and from 65 control subjects. Periodontal examination consisted of taking probing depth and attachment loss measurements. The levels of plasma C-reactive protein and interleukin-6 were determined using enzyme-linked immunosorbent assays.

The levels of plasma C-reactive protein in patients with aggressive periodontitis were significantly higher than those in control subjects (1.87 vs. 0.52 mg/L). The level of plasma interleukin-6 in patients with aggressive periodontitis was 1.20 pg/mL, higher than that in control subjects (0.08 pg/mL). Multiple linear regression analysis showed that log C-reactive protein was significantly related to severe sites percentage and albumin following correction for age, gender, body mass index and smoking (p = 0.000, p = 0.008, respectively). Log interleukin-6 was found to be significantly correlated with periodontal diagnosis, leukocyte count and level of fasting blood glucose after adjusting for the confounders (p = 0.000, p = 0.009 and p = 0.013, respectively).

Patients with aggressive periodontitis have significantly elevated levels of plasma C-reactive protein and interleukin-6. These elevated inflammatory factors might potentially increase the risk for cardiovascular events and glucose dysregulation in relatively young individuals.

语种英语
WOS记录号WOS:000265556000005
项目编号30471882 ; 2007BAZ18B02
资助机构National Natural Science Foundations of China ; National Key Project of Scientific and Technical Supporting Programs of China ; Clinical Research Fund, Ministry of Health
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58142
专题北京大学口腔医学院_牙周科
北京大学第三临床医学院_麻醉科
作者单位Peking Univ, Sch & Hosp Stomatol, Dept Periodontol, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Sun, X. J.,Meng, H. X.,Shi, D.,et al. Elevation of C-reactive protein and interleukin-6 in plasma of patients with aggressive periodontitis[J]. JOURNAL OF PERIODONTAL RESEARCH,2009,44(3):311-316.
APA Sun, X. J..,Meng, H. X..,Shi, D..,Xu, L..,Zhang, L..,...&Ren, X. Y..(2009).Elevation of C-reactive protein and interleukin-6 in plasma of patients with aggressive periodontitis.JOURNAL OF PERIODONTAL RESEARCH,44(3),311-316.
MLA Sun, X. J.,et al."Elevation of C-reactive protein and interleukin-6 in plasma of patients with aggressive periodontitis".JOURNAL OF PERIODONTAL RESEARCH 44.3(2009):311-316.
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