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学科主题: 临床医学
题名:
Effects of the Number and Interval of Balloon Inflations during Primary PCI on the Extent of Myocardial Injury in Patients with STEMI: Does Postconditioning Exist in Real-World Practice?
作者: Wang, Guisong2; Zhang, Sanguo3,4; Joggerst, Steven J.; McPherson, John; Zhao, David X.1
关键词: Myocardial infarction ; postconditioning ; ischemia reperfusion ; cardioprotection
刊名: JOURNAL OF INVASIVE CARDIOLOGY
发表日期: 2009-09-01
卷: 21, 期:9, 页:451-455
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: PERCUTANEOUS CORONARY INTERVENTION ; PRIMARY ANGIOPLASTY ; INFARCT SIZE ; HUMAN HEART ; REPERFUSION ; RESOLUTION ; MULTIPLE ; BENEFIT ; TERM
英文摘要:

Postconditioning reduces infarct size in animal models and clinical studies The present retrospective study aimed to evaluate the effects of the number and interval delay of balloon inflations during primary percutaneous coronary intervention (PCI) on enzymatic infarct size myocardial perfusion and cardiac function in patients with ST-segment elevation myocardial infarction (STEMI) in routine clinical practice Methods Of the 433 STEMI patients who underwent primary PCI at Vanderbilt University Medical Center from October 2003 to August 2007, 85 (19 6%) met criteria and were en rolled into two groups those with >= 3 versus with <= 2 balloon inflations Peak CK ST segment resolution, myocardial blush grade (MBG) and left ventricular (LV) function were compared between the two groups Correlations of peak CK MBG and LV ejection fraction (LVEF) with the number average duration and the first delay interval of balloon inflations were analyzed A stepwise multiple regression analysis was used to identify the possible determinants of echocardiographic LVEF Results The LV end-systolic volume (LVESV) index in the group with >= 3 inflations was significantly lower than that with <= 2 inflations (33 1 +/- 7 9 ml/m(2) versus 37 5 +/- 11 2 ml/m(2) p = 0 036) while LVEF was significantly higher (50 4 +/- 6 3% versus 46 1 +/- 8 5% p = 0 009) Post hoc analysis showed peak CK in patients with 4 inflations was significantly lower than that with <= 2 inflations (1 698 +/- 1 266 IU/L vs 2 603 +/- 1 532 IU/L p < 0 05) There was a positive correlation between LVEF and the number of balloon inflations (r = 0 222 p = 0 041) Conclusions Repetitive balloon inflations during primary PO appear to confer cardioprotection The data suggest that postconditioning may exist in real-world practice and contribute to myocardial protection

语种: 英语
WOS记录号: WOS:000284807000007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58144
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Vanderbilt Univ, Med Ctr, Cardiac Catheterizat Lab, Div Cardiovasc Med, Nashville, TN 37232 USA
2.Peking Univ, Dept Cardiol, Hosp 3, Beijing 100871, Peoples R China
3.Vanderbilt Univ, Dept Biostat, Sch Med, Nashville, TN 37232 USA
4.Chinese Acad Sci, Sch Math Sci, Grad Univ, Beijing, Peoples R China

Recommended Citation:
Wang, Guisong,Zhang, Sanguo,Joggerst, Steven J.,et al. Effects of the Number and Interval of Balloon Inflations during Primary PCI on the Extent of Myocardial Injury in Patients with STEMI: Does Postconditioning Exist in Real-World Practice?[J]. JOURNAL OF INVASIVE CARDIOLOGY,2009,21(9):451-455.
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