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学科主题: 药学
题名:
A series of strategies for solving the shortage of reference standards for multi-components determination of traditional Chinese medicine, Mahoniae Caulis as a case
作者: Wang, Wenguang; Ma, Xiaoli; Guo, Xiaoyu; Zhao, Mingbo; Tu, Pengfei; Jiang, Yong
关键词: Traditional Chinese medicine ; Reference standards shortage ; One single reference standard to determine multi-compounds ; Quantitative analysis by standardized reference extract ; Quantitative nuclear magnetic resonance spectroscopy ; Relative expanded uncertainty of measurement
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2015-09-18
DOI: 10.1016/j.chroma.2015.08.015
卷: 1412, 页:100-111
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: SINGLE REFERENCE-STANDARD ; MASS-SPECTROMETRY ; UNCERTAINTY ; QUANTIFICATION ; SPECTROSCOPY
英文摘要:

In order to solve the bottleneck of reference standards shortage for comprehensive quality control of traditional Chinese medicines (TCMs), a series of strategies, including one single reference standard to determine multi-compounds (SSDMC), quantitative analysis by standardized reference extract (QASRE), and quantitative nuclear magnetic resonance spectroscopy (qNMR) were proposed, and Mahoniae Caulis was selected as an example to develop and validate these methods for simultaneous determination of four alkaloids, columbamine, jatrorrhizine, palmatine, and berberine. Comprehensive comparisons among these methods and with the conventional external standard method (ESM) were carried out. The relative expanded uncertainty of measurement was firstly used to compare their credibility. The results showed that all these three new developed methods can accurately accomplish the quantification by using only one purified reference standard, but each of them has its own advantages and disadvantages as well as the specific application scope, which were also discussed in detail in this paper. (C) 2015 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 81222051 ; 2012ZX09301002-002-002 ; 2012ZX09304-005
项目资助者: National Natural Sciences Foundation of China ; Chinese Pharmacopoeia Commission ; National Key Technology R&amp ; D Program "New Drug Innovation" of China
WOS记录号: WOS:000361252000012
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58148
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Wenguang,Ma, Xiaoli,Guo, Xiaoyu,et al. A series of strategies for solving the shortage of reference standards for multi-components determination of traditional Chinese medicine, Mahoniae Caulis as a case[J]. JOURNAL OF CHROMATOGRAPHY A,2015,1412:100-111.
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