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A series of strategies for solving the shortage of reference standards for multi-components determination of traditional Chinese medicine, Mahoniae Caulis as a case
Wang, Wenguang; Ma, Xiaoli; Guo, Xiaoyu; Zhao, Mingbo; Tu, Pengfei; Jiang, Yong
关键词Traditional Chinese Medicine Reference Standards Shortage One Single Reference Standard To Determine Multi-compounds Quantitative Analysis By Standardized Reference Extract Quantitative Nuclear Magnetic Resonance Spectroscopy Relative Expanded Uncertainty Of Measurement
刊名JOURNAL OF CHROMATOGRAPHY A
2015-09-18
DOI10.1016/j.chroma.2015.08.015
1412页:100-111
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
资助者National Natural Sciences Foundation of China ; Chinese Pharmacopoeia Commission ; National Key Technology R&amp ; D Program "New Drug Innovation" of China ; National Natural Sciences Foundation of China ; Chinese Pharmacopoeia Commission ; National Key Technology R&amp ; D Program "New Drug Innovation" of China
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]SINGLE REFERENCE-STANDARD ; MASS-SPECTROMETRY ; UNCERTAINTY ; QUANTIFICATION ; SPECTROSCOPY
英文摘要

In order to solve the bottleneck of reference standards shortage for comprehensive quality control of traditional Chinese medicines (TCMs), a series of strategies, including one single reference standard to determine multi-compounds (SSDMC), quantitative analysis by standardized reference extract (QASRE), and quantitative nuclear magnetic resonance spectroscopy (qNMR) were proposed, and Mahoniae Caulis was selected as an example to develop and validate these methods for simultaneous determination of four alkaloids, columbamine, jatrorrhizine, palmatine, and berberine. Comprehensive comparisons among these methods and with the conventional external standard method (ESM) were carried out. The relative expanded uncertainty of measurement was firstly used to compare their credibility. The results showed that all these three new developed methods can accurately accomplish the quantification by using only one purified reference standard, but each of them has its own advantages and disadvantages as well as the specific application scope, which were also discussed in detail in this paper. (C) 2015 Elsevier B.V. All rights reserved.

语种英语
所属项目编号81222051 ; 2012ZX09301002-002-002 ; 2012ZX09304-005
资助者National Natural Sciences Foundation of China ; Chinese Pharmacopoeia Commission ; National Key Technology R&amp ; D Program "New Drug Innovation" of China ; National Natural Sciences Foundation of China ; Chinese Pharmacopoeia Commission ; National Key Technology R&amp ; D Program "New Drug Innovation" of China
WOS记录号WOS:000361252000012
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58148
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
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Wang, Wenguang,Ma, Xiaoli,Guo, Xiaoyu,et al. A series of strategies for solving the shortage of reference standards for multi-components determination of traditional Chinese medicine, Mahoniae Caulis as a case[J]. JOURNAL OF CHROMATOGRAPHY A,2015,1412:100-111.
APA Wang, Wenguang,Ma, Xiaoli,Guo, Xiaoyu,Zhao, Mingbo,Tu, Pengfei,&Jiang, Yong.(2015).A series of strategies for solving the shortage of reference standards for multi-components determination of traditional Chinese medicine, Mahoniae Caulis as a case.JOURNAL OF CHROMATOGRAPHY A,1412,100-111.
MLA Wang, Wenguang,et al."A series of strategies for solving the shortage of reference standards for multi-components determination of traditional Chinese medicine, Mahoniae Caulis as a case".JOURNAL OF CHROMATOGRAPHY A 1412(2015):100-111.
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