北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 儿科  > 期刊论文
学科主题: 临床医学
题名:
Pathogenic Role of UPR (Unfolded Protein Response) Among Hereditary Leukoencephalopathy and Neurodegenerative Disorders After Endoplasmic Reticulum Stress
作者: Chen Na; Dai Li-Fang; Jiang Yu-Wu; Wu Ye
关键词: endoplasmic reticulum stress ; unfolded protein response ; neurodegenerative disorder
刊名: PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
发表日期: 2012-08-01
DOI: 10.3724/SP.J.1206.2012.00097
卷: 39, 期:8, 页:764-770
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: PELIZAEUS-MERZBACHER-DISEASE ; WHITE-MATTER DISEASE ; INDUCED CELL-DEATH ; PROTEOLIPID PROTEIN ; AMYLOID-BETA ; ALZHEIMERS-DISEASE ; INDUCED APOPTOSIS ; OXIDATIVE STRESS ; QUALITY-CONTROL ; IN-VITRO
英文摘要:

Endoplasmic reticulum (ER) is the protein-folding compartment. When the aggregation of unfolded or misfolded protein in the ER lumen excesses its folding capacity, unfolded protein response (UPR) and ER-associated protein degradation (ERAD) would be activated to eliminate the overload of nascent protein. However, the persistent ER stress would trigger apoptosis pathway and lead to cell death. There exist three pathways in the UPR process, which are mediated by three membrane receptors: PERK, ATF6 or IRE1 respectively. The first activated PERK would down regulates the protein synthesis through the phosphorylation of eukaryotic initiation factor (eIF) 2 alpha (eIF2 alpha) and activate the upstream open reading frame. ATF6 and IRE1 also make the contribution to UPR. Up to now, the most studied neurodegenerative diseases that related to ER stresses are Alzheimer′s disease, Parkinson′s disease, Vanishing White Matter disease, Pelizaeus-Merzbacher disease, Charcot-Marie-Tooth disease and CAG triplet repeat diseases (as Huntington′s disease and Spinocerebellar ataxia).

语种: 中文
所属项目编号: 81171065
项目资助者: National Natural Science Foundation of China ; Sponsor Program for The New Century Elites from The Ministry of Education of China
WOS记录号: WOS:000307851900013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58150
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China

Recommended Citation:
Chen Na,Dai Li-Fang,Jiang Yu-Wu,et al. Pathogenic Role of UPR (Unfolded Protein Response) Among Hereditary Leukoencephalopathy and Neurodegenerative Disorders After Endoplasmic Reticulum Stress[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2012,39(8):764-770.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Chen Na]'s Articles
[Dai Li-Fang]'s Articles
[Jiang Yu-Wu]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Chen Na]‘s Articles
[Dai Li-Fang]‘s Articles
[Jiang Yu-Wu]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace