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学科主题: 临床医学
题名:
Activation and Up-Regulation of Translation Initiation Factor 4B Contribute to Arsenic-Induced Transformation
作者: Zhang, Yong1,2,3; Wang, Qing1; Guo, Xiaoling1,4,5; Miller, Robert1; Guo, Yinglu2,3; Yang, Hsin-Sheng1,6
关键词: transformation ; eIF4B ; arsenic ; c-Myc
刊名: MOLECULAR CARCINOGENESIS
发表日期: 2011-07-01
DOI: 10.1002/mc.20733
卷: 50, 期:7, 页:528-538
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Oncology
研究领域[WOS]: Biochemistry & Molecular Biology ; Oncology
关键词[WOS]: INDUCED MALIGNANT TRANSFORMATION ; SUPPRESSOR PDCD4 ; MESSENGER-RNAS ; ANCHORAGE INDEPENDENCE ; EUKARYOTIC TRANSLATION ; AP-1 TRANSACTIVATION ; CELLS ; EXPRESSION ; PROMOTER ; PROTEIN
英文摘要:

Arsenic is a known human carcinogen. However, the mechanism of how arsenic induces cell transformation remains unclear. In this study, we demonstrated that long-term exposure to sodium arsenite at low-dose (2 mu M) increases cell proliferation and neoplastic transformation in a mouse epidermal cell model, JB6 promotion-susceptible cells. The phosphorylation of AKT and its downstream targets, 70-kDa ribosomal protein S6 kinase (p70S6K) and translation initiation factor 4B (eIF4B), are increased in the arsenite treated cells, indicating that long-term arsenite treatment activates AKT-p70S6K signaling pathway. In addition, long-term exposure to arsenite up-regulates eIF4B expression and increases the rate of translation. Knockdown of eIF4B expression resulted in inhibition of arsenic-induced cell proliferation, transformation, and translation. Moreover, the expression of c-Myc which is up-regulated by long-term arsenite treatment is inhibited by eIF4B knockdown. Taken together, these results indicate that activation and up-regulation of eIF4B contributes to arsenic-induced transformation in JB6 cells. (C) 2011 Wiley-Liss, Inc.

语种: 英语
所属项目编号: R01CA129015
项目资助者: National Cancer Institute
WOS记录号: WOS:000291606900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58153
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ First Hosp, Inst Urol, Beijing, Peoples R China
2.Peking Univ First Hosp, Dept Urol, Beijing, Peoples R China
3.Univ Kentucky, Coll Med, Grad Ctr Toxicol, Lexington, KY 40536 USA
4.Shandong Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Jinan, Shandong, Peoples R China
5.Shandong Univ, Hosp Stomatol, Dept Oral & Maxillofacial Surg, Jinan, Shandong, Peoples R China
6.Univ Kentucky, Coll Med, Lucille P Markey Canc Ctr, Lexington, KY 40536 USA

Recommended Citation:
Zhang, Yong,Wang, Qing,Guo, Xiaoling,et al. Activation and Up-Regulation of Translation Initiation Factor 4B Contribute to Arsenic-Induced Transformation[J]. MOLECULAR CARCINOGENESIS,2011,50(7):528-538.
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