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学科主题: 药学
题名:
Toward the development of chemoprevention agents. Part 1: Design, synthesis, and anti-inflammatory activities of a new class of 2,5-disubstituted-dioxacycloalkanes
作者: Gu, Keli; Bi, Lanrong; Zhao, Ming; Wang, Chao; Ju, Jingfang; Peng, Shiqi
关键词: chemoprevention agents ; stereoselective synthesis ; 2,5-disubstituted-dioxacycloalkanes ; anti-inflammatory activity ; structure-activity relationship study
刊名: BIOORGANIC & MEDICINAL CHEMISTRY
发表日期: 2007-07-15
DOI: 10.1016/j.bmc.2007.05.013
卷: 15, 期:14, 页:4775-4799
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: PROTEIN-KINASE-C ; PROSTAGLANDIN G/H SYNTHASE ; COLORECTAL-CANCER ; KETOROLAC TROMETHAMINE ; COX-2 INHIBITORS ; CELLS ; INFLAMMATION ; VOLUNTEERS ; MECHANISMS ; HEMORRHAGE
英文摘要:

A new class of 2,5-disubstituted-dioxacycloalkanes were designed and synthesized via stereoselective synthetic method as cancer chemoprevention agents. The anti-inflammatory activities of these compounds were tested using the xylene-induced mouse ear edema model. Some of these compounds exhibited comparable or better anti-inflammatory activities than that of aspirin suggesting that they can be Further developed as potential anti-inflammatory drug lead compounds. In addition, treatment of these anti-inflammatory agents did not prolong tail bleeding time in mice. The structure/activity relationships were also analyzed among these compounds. (c) 2007 Elsevier Ltd. All. rights reserved.

语种: 英语
WOS记录号: WOS:000247583300009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58159
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.USA Mitchell Canc Inst, Mobile, AL 36688 USA
2.Capital Univ Med Sci, Coll Pharmaceut Sci, Beijing 100054, Peoples R China
3.Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Gu, Keli,Bi, Lanrong,Zhao, Ming,et al. Toward the development of chemoprevention agents. Part 1: Design, synthesis, and anti-inflammatory activities of a new class of 2,5-disubstituted-dioxacycloalkanes[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2007,15(14):4775-4799.
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