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Toward the development of chemoprevention agents. Part 1: Design, synthesis, and anti-inflammatory activities of a new class of 2,5-disubstituted-dioxacycloalkanes
Gu, Keli; Bi, Lanrong; Zhao, Ming; Wang, Chao; Ju, Jingfang; Peng, Shiqi
关键词Chemoprevention Agents Stereoselective Synthesis Anti-inflammatory Activity 2 Structure-activity Relationship Study 5-disubstituted-dioxacycloalkanes
刊名BIOORGANIC & MEDICINAL CHEMISTRY
2007-07-15
DOI10.1016/j.bmc.2007.05.013
15期:14页:4775-4799
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
关键词[WOS]PROTEIN-KINASE-C ; PROSTAGLANDIN G/H SYNTHASE ; COLORECTAL-CANCER ; KETOROLAC TROMETHAMINE ; COX-2 INHIBITORS ; CELLS ; INFLAMMATION ; VOLUNTEERS ; MECHANISMS ; HEMORRHAGE
英文摘要

A new class of 2,5-disubstituted-dioxacycloalkanes were designed and synthesized via stereoselective synthetic method as cancer chemoprevention agents. The anti-inflammatory activities of these compounds were tested using the xylene-induced mouse ear edema model. Some of these compounds exhibited comparable or better anti-inflammatory activities than that of aspirin suggesting that they can be Further developed as potential anti-inflammatory drug lead compounds. In addition, treatment of these anti-inflammatory agents did not prolong tail bleeding time in mice. The structure/activity relationships were also analyzed among these compounds. (c) 2007 Elsevier Ltd. All. rights reserved.

语种英语
WOS记录号WOS:000247583300009
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58159
专题北京大学药学院
作者单位1.USA Mitchell Canc Inst, Mobile, AL 36688 USA
2.Capital Univ Med Sci, Coll Pharmaceut Sci, Beijing 100054, Peoples R China
3.Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Gu, Keli,Bi, Lanrong,Zhao, Ming,et al. Toward the development of chemoprevention agents. Part 1: Design, synthesis, and anti-inflammatory activities of a new class of 2,5-disubstituted-dioxacycloalkanes[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2007,15(14):4775-4799.
APA Gu, Keli,Bi, Lanrong,Zhao, Ming,Wang, Chao,Ju, Jingfang,&Peng, Shiqi.(2007).Toward the development of chemoprevention agents. Part 1: Design, synthesis, and anti-inflammatory activities of a new class of 2,5-disubstituted-dioxacycloalkanes.BIOORGANIC & MEDICINAL CHEMISTRY,15(14),4775-4799.
MLA Gu, Keli,et al."Toward the development of chemoprevention agents. Part 1: Design, synthesis, and anti-inflammatory activities of a new class of 2,5-disubstituted-dioxacycloalkanes".BIOORGANIC & MEDICINAL CHEMISTRY 15.14(2007):4775-4799.
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