IR@PKUHSC  > 北京大学第三临床医学院  > 血液内科
学科主题临床医学
The Four types of Tregs in malignant lymphomas
Wang, Jing; Ke, Xiao-Yan1
关键词Lymphomas Regulator t Cells Prognosis
刊名JOURNAL OF HEMATOLOGY & ONCOLOGY
2011-12-09
DOI10.1186/1756-8722-4-50
4
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology
研究领域[WOS]Oncology ; Hematology
关键词[WOS]REGULATORY T-CELLS ; NON-HODGKINS-LYMPHOMA ; FOLLICULAR LYMPHOMA ; TUMOR-IMMUNITY ; PROGNOSTIC IMPACT ; SEZARY-SYNDROME ; HIGH NUMBERS ; FOXP3 ; EXPRESSION ; SURVIVAL
英文摘要

Regulatory T cells (Tregs) are a specialized subpopulation of CD4(+) T cells, which act to suppress the activation of other immune cells. Tregs represent important modulators for the interaction between lymphomas and host microenvironment. Lymphomas are a group of serious and frequently fatal malignant diseases of lymphocytes. Recent studies revealed that some lymphoma T cells might adopt a Treg profile. Assessment of Treg phenotypes and genotypes in patients may offer prediction of outcome in many types of lymphomas including diffuse large B-cell lymphoma, follicular lymphoma, cutaneous T cell lymphoma, and Hodgkin′s lymphoma. Based on characterized roles of Tregs in lymphomas, we can categorize the various roles into four groups: (a) suppressor Tregs; (b) malignant Tregs; (c) direct tumor-killing Tregs; and (d) incompetent Tregs. The classification into four groups is significant in predicting prognosis and designing Tregs-based immunotherapies for treating lymphomas. In patients with lymphomas where Tregs serve either as suppressor Tregs or malignant Tregs, anti-tumor cytotoxicity is suppressed thus decreased numbers of Tregs are associated with a good prognosis. In contrast, in patients with lymphomas where Tregs serve as tumor-killing Tregs and incompetent Tregs, anti-tumor cytotoxicity is enhanced or anti-autoimmune Tregs activities are weakened thus increased numbers of Tregs are associated with a good prognosis and reduced numbers of Tregs are associated with a poor prognosis. However, the mechanisms underlying the various roles of Tregs in patients with lymphomas remain unknown. Therefore, further research is needed in this regard as well as the utility of Tregs as prognostic factors and therapy strategies in different lymphomas.

语种英语
WOS记录号WOS:000298926400001
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58166
Collection北京大学第三临床医学院_血液内科
作者单位1.Peking Univ, Hosp 3, Dept Hematol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Lymphoma Res Ctr, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Wang, Jing,Ke, Xiao-Yan. The Four types of Tregs in malignant lymphomas[J]. JOURNAL OF HEMATOLOGY & ONCOLOGY,2011,4.
APA Wang, Jing,&Ke, Xiao-Yan.(2011).The Four types of Tregs in malignant lymphomas.JOURNAL OF HEMATOLOGY & ONCOLOGY,4.
MLA Wang, Jing,et al."The Four types of Tregs in malignant lymphomas".JOURNAL OF HEMATOLOGY & ONCOLOGY 4(2011).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Wang, Jing]'s Articles
[Ke, Xiao-Yan]'s Articles
百度学术
百度学术Similar articles in
[Wang, Jing]'s Articles
[Ke, Xiao-Yan]'s Articles
必应学术
必应学术Similar articles in
[Wang, Jing]'s Articles
[Ke, Xiao-Yan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.