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Extramedullary Relapse of Acute Leukemia after Haploidentical Hematopoietic Stem Cell Transplantation: Incidence, Risk Factors, Treatment, and Clinical Outcomes
Mo, Xiao-Dong1,2; Kong, Jun1,2; Zhao, Ting1,2; Xu, Lan-Ping1,2; Zhang, Xiao-Hui1,2; Liu, Dai-Hong1,2; Wang, Yu1,2; Chen, Huan1,2; Yan, Chen-Hua1,2; Chen, Yu-Hong1,2; Han, Wei1,2; Wang, Feng-Rong1,2; Wang, Jing-Zhi1,2; Liu, Kai-Yan1,2; Huang, Xiao-Jun1,2,3
关键词Extramedullary Relapse Chronic Graft-versus-host Disease Hematopoietic Stem Cell Transplantation Haploidentical Acute Leukemia
刊名BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
2014-12-01
DOI10.1016/j.bbmt.2014.08.023
20期:12页:2023-2028
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Immunology ; Transplantation
研究领域[WOS]Hematology ; Immunology ; Transplantation
关键词[WOS]BONE-MARROW-TRANSPLANTATION ; ACUTE MYELOID-LEUKEMIA ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; VERSUS-HOST-DISEASE ; ACUTE MYELOGENOUS LEUKEMIA ; TERM-FOLLOW-UP ; GRANULOCYTIC SARCOMA ; RANDOMIZED-TRIAL ; SINGLE-CENTER ; CHRONIC GRAFT
英文摘要

We examined the incidence, risk factors, treatment, and clinical outcomes of extramedullary relapse (EMR) in 961 acute leukemia patients undergoing HLA-haploidentical hematopoietic stem cell transplantation (haplo-HSCT) between 2002 and 2013. Multiple control subjects were selected at random from the same cohort and matched to EMR cases for diagnosis, disease status at HSCT, age at the time of the HSCT, and year of HSCT. Forty patients exhibited EMR, with a median time to EMR of 207 days. The cumulative incidence of EMR was 4.0% at 3 years, and the incidence was higher in acute lymphoblastic leukemia patients compared with acute myeloid leukemia patients (5.6% versus 2.4%). In the multivariate analysis, non complete remission (CR) status at HSCT (hazard ratio [HR] = 4.6; P = .018) and non chronic graft-versus-host disease after HSCT (HR = 3.2; P < .001) were the independent risk factors for EMR after haplo-HSCT. Twenty-seven patients received combination treatments, and the proportion of patients who achieved CR was higher than those who received single treatment. Multifocal involvement at EMR (HR = 2.7; P = .024) and non-CR after EMR treatments (HR = 4.6; P < .001) were the independent risk factors for poor survival rates among EMR patients. We found that graft-versus-leukemia effect may help to prevent EMR after haplo-HSCT. (C) 2014 American Society for Blood and Marrow Transplantation.

语种英语
WOS记录号WOS:000345606500023
项目编号Z111107067311070 ; Z121107001012085 ; 81230013
资助机构Beijing Municipal Science and Technology Program ; Clinical Characteristic Study of Capital Project ; Key Program of the National Natural Science Foundation of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58173
专题北京大学第二临床医学院
医学人文研究院/公共教学部_哲学与社会科学系
北京大学第二临床医学院_血液科
作者单位1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Univ, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China
3.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Mo, Xiao-Dong,Kong, Jun,Zhao, Ting,et al. Extramedullary Relapse of Acute Leukemia after Haploidentical Hematopoietic Stem Cell Transplantation: Incidence, Risk Factors, Treatment, and Clinical Outcomes[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2014,20(12):2023-2028.
APA Mo, Xiao-Dong.,Kong, Jun.,Zhao, Ting.,Xu, Lan-Ping.,Zhang, Xiao-Hui.,...&Huang, Xiao-Jun.(2014).Extramedullary Relapse of Acute Leukemia after Haploidentical Hematopoietic Stem Cell Transplantation: Incidence, Risk Factors, Treatment, and Clinical Outcomes.BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,20(12),2023-2028.
MLA Mo, Xiao-Dong,et al."Extramedullary Relapse of Acute Leukemia after Haploidentical Hematopoietic Stem Cell Transplantation: Incidence, Risk Factors, Treatment, and Clinical Outcomes".BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 20.12(2014):2023-2028.
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