IR@PKUHSC  > 北京大学第二临床医学院  > 北京大学肝病研究所
学科主题临床医学
Genomic and evolutionary characterization of TT virus (TTV) in tupaias and comparison with species-specific TTVs in humans and non-human primates
Okamoto, H; Nishizawa, T; Takahashi, M; Tawara, A; Peng, YH; Kishimoto, J; Wang, Y
刊名JOURNAL OF GENERAL VIROLOGY
2001-09-01
82页:2041-2050
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Virology
研究领域[WOS]Biotechnology & Applied Microbiology ; Virology
关键词[WOS]CHICKEN ANEMIA VIRUS ; FEATHER DISEASE VIRUS ; NONHUMAN-PRIMATES ; NUCLEOTIDE-SEQUENCE ; PORCINE CIRCOVIRUS ; POSTTRANSFUSION HEPATITIS ; PLANT CIRCOVIRUSES ; UNKNOWN ETIOLOGY ; HIGH PREVALENCE ; TREE SHREWS
英文摘要

TT virus (TTV) was recovered from the sera of tupaias (Tupaia belangeri chinensis) by PCR using primers derived from the noncoding region of the human TTV genome, and its entire genomic sequence was determined. One tupaia T-TV isolate (Tbc-TTV1 4) consisted of only 2199 nucleotides (nt) and had three open reading frames (ORFs), spanning 1506 nt (ORF1), 177 nt (ORF2) and 642 nt (ORF3), which were in the same orientation as the ORFs of the human prototype TTV (TA278). ORF3 was presumed to arise from a splicing of TTV mRNA, similar to reported human TTVs whose spliced mRNAs have been identified, and encoded a joint protein of 214 amino acids with a Ser-, Lys- and Arg-rich sequence at the C terminus. Tbc-TTV 14 was less than 50% similar to previously reported TTVs of 3.4-3.9 kb and TTV-like mini viruses (TLMVs) of 2.8-3.0 kb isolated from humans and non-human primates, and known animal circoviruses. Although Tbc-TTV1 4 has a genomic length similar to animal circoviruses (1.8-2.3 kb), Tbc-TTV1 4 resembled TTVs and TLMVs with regard to putative genomic organization and transcription profile. Conserved motifs were commonly observed in the coding and noncoding regions of the Tbc-TTV 14 genome and in all TTV and TLMV genomes. Phylogenetic analysis revealed that Tbc-TTV1 4 is the closest to TLMVs, and is closer to TTVs isolated from tamarin and douroucouli than to TTVs isolated from humans and chimpanzees. These results indicate that tupaias are naturally infected with a new TTV species that has not been identified among primates.

语种英语
WOS记录号WOS:000170707800003
Citation statistics
Cited Times:72[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58175
Collection北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Inst Immunol, Tokyo 1120004, Japan
2.Jichi Med Sch, Div Immunol, Minami Kawachi, Tochigi 3290498, Japan
3.Jichi Med Sch, Div Mol Virol, Minami Kawachi, Tochigi 3290498, Japan
4.Yamanashi Med Univ, Dept Internal Med 1, Kofu, Yamanashi 4093898, Japan
5.Beijing Univ, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Okamoto, H,Nishizawa, T,Takahashi, M,et al. Genomic and evolutionary characterization of TT virus (TTV) in tupaias and comparison with species-specific TTVs in humans and non-human primates[J]. JOURNAL OF GENERAL VIROLOGY,2001,82:2041-2050.
APA Okamoto, H.,Nishizawa, T.,Takahashi, M.,Tawara, A.,Peng, YH.,...&Wang, Y.(2001).Genomic and evolutionary characterization of TT virus (TTV) in tupaias and comparison with species-specific TTVs in humans and non-human primates.JOURNAL OF GENERAL VIROLOGY,82,2041-2050.
MLA Okamoto, H,et al."Genomic and evolutionary characterization of TT virus (TTV) in tupaias and comparison with species-specific TTVs in humans and non-human primates".JOURNAL OF GENERAL VIROLOGY 82(2001):2041-2050.
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