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学科主题: 基础医学
题名:
Effect of chronic unpredictable mild stress on brain-pancreas relative protein in rat brain and pancreas
作者: Lin, YH; Liu, AH; Xu, Y; Tie, L; Yu, HM; Li, XJ
关键词: brain-pancreas relative protein ; chronic unpredictable mild stress ; depression ; diabetes
刊名: BEHAVIOURAL BRAIN RESEARCH
发表日期: 2005-11-30
DOI: 10.1016/j.bbr.2005.06.034
卷: 165, 期:1, 页:63-71
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]: DEPRESSIVE SYMPTOMS ; ANIMAL-MODELS ; HIPPOCAMPAL NEUROGENESIS ; SUCROSE CONSUMPTION ; TYPE-2 ; RISK ; VALIDITY ; ANTIDEPRESSANT ; VALIDATION ; INHIBITORS
英文摘要:

Brain-pancreas relative protein (BPRP) is a novel protein whose biological function remains unknown. Here, we report a possible role of BPRP in male rats exposed to chronic unpredictable mild stress (CUMS) to induce depression for 3 weeks. Compared to unstressed rats, those exposed to CUMS showed significantly less weight gain with age, decreased consumption of (and preference for) sucrose without a change in total fluid consumption. Exposure to CUMS significantly reduced open-field exploration, rearing and grooming indicative of lethargy, apathy and bodily neglect, respectively. Brain MAO-A and MAO-B activity were both significantly increased in the stressed rats. These results verified induction of depressive symptoms by CUMS. The stressed animals showed a significant reduction in pancreatic BPRP, which was accompanied by an increase in levels of blood sugar and a decrease of insulin. But they showed no apparent alteration in levels or distribution of BPRP in the hippocampal formation, which nevertheless displayed a thinner dentate granule cell layer perhaps related to elevated MAO-B activity. These findings suggest that stress-induced reduction of pancreatic BPRP may cause diabetic symptoms. Whether those symptoms in turn contribute to the onset of depression requires further study. (c) 2005 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000233091100008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58184
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100083, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
4.Nat Res Inst Family Planning, Beijing 100081, Peoples R China

Recommended Citation:
Lin, YH,Liu, AH,Xu, Y,et al. Effect of chronic unpredictable mild stress on brain-pancreas relative protein in rat brain and pancreas[J]. BEHAVIOURAL BRAIN RESEARCH,2005,165(1):63-71.
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