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学科主题基础医学
The effects of morphine on basal neuronal activities in the lateral and medial pain pathways
Su, Yuan-Lin1,2; Huang, Jin3; Wang, Ning1; Wang, Jin-Yan1; Luo, Fei1
关键词Morphine Spontaneous activity The primary somatosensory cortex The anterior cingulate cortex Thalamus
刊名NEUROSCIENCE LETTERS
2012-09-13
DOI10.1016/j.neulet.2012.07.032
525期:2页:173-178
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]ANTERIOR CINGULATE CORTEX ; THALAMIC NUCLEI ; RATS ; STIMULATION ; RESPONSES ; BRAIN ; DIZOCILPINE ; ACTIVATION ; EXCITATION ; ANALGESIA
英文摘要

Numerous studies indicate that morphine suppresses pain-evoked activities in both spinal and supraspinal regions. However, little is known about the effect of morphine on the basal brain activity in the absence of pain. The present study was designed to assess the effects of single-dose morphine on the spontaneous discharge of many simultaneously recorded single units, as well as their functional connections, in the lateral pain pathway, including the primary somatosensory cortex (SI) and ventral posterolateral thalamus (VPL), and medial pain pathway, including the anterior cingulate cortex (ACC) and medial dorsal thalamus (MD), in awake rats. Morphine (5 mg/kg) was administered intraperitoneally before the recording. Naloxone plus morphine and normal saline injections were performed respectively as controls. The results showed that morphine administration produced significant changes in the spontaneous neuronal activity in more than one third of the total recorded neurons, with primary activation in the lateral pathway while both inhibition and activation in the medial pathway. Naloxone pretreatment completely blocked the effects induced by morphine. In addition, the correlated activities between and within both pain pathways was exclusively suppressed after morphine injection. These results suggest that morphine may play different roles in modulating neural activity in normal vs. pain states. Taken together, this is the first study investigating the morphine modulation of spontaneous neuronal activity within parallel pain pathways. It can be helpful for revealing neuronal population coding for the morphine action in the absence of pain, and shed light on the supraspinal mechanisms for preemptive analgesia. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000309015600017
项目编号KSCX2-EW-Q-18 ; YZ200944 ; KSCX2-YW-R-254 ; KSCX2-EW-J-8 ; 30770688 ; 30970959 ; 61033011 ; 31171067 ; R03 TW008038
资助机构Chinese Academy of Sciences ; NNSF ; NIH Fogarty International Center
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58188
专题北京大学基础医学院_神经生物学系
北京大学第三临床医学院_妇产科
作者单位1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Beijing 100871, Peoples R China
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GB/T 7714
Su, Yuan-Lin,Huang, Jin,Wang, Ning,et al. The effects of morphine on basal neuronal activities in the lateral and medial pain pathways[J]. NEUROSCIENCE LETTERS,2012,525(2):173-178.
APA Su, Yuan-Lin,Huang, Jin,Wang, Ning,Wang, Jin-Yan,&Luo, Fei.(2012).The effects of morphine on basal neuronal activities in the lateral and medial pain pathways.NEUROSCIENCE LETTERS,525(2),173-178.
MLA Su, Yuan-Lin,et al."The effects of morphine on basal neuronal activities in the lateral and medial pain pathways".NEUROSCIENCE LETTERS 525.2(2012):173-178.
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