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学科主题: 临床医学
题名:
Association between carotid artery intima-media thickness and early-stage CKD in a Chinese population
作者: Zhang, LuXia; Zhao, Feng; Yang, Ying; Qi, LiTong; Zhang, Bao Wei; Wang, Fang; Wang, ShuYu; Liu, LiSheng; Wang, HaiYan
关键词: intima-media thickness (IMT) ; chronic kidney disease (CKD) ; Chinese
刊名: AMERICAN JOURNAL OF KIDNEY DISEASES
发表日期: 2007-06-01
DOI: 10.1053/j.ajkd.2007.03.011
卷: 49, 期:6, 页:786-792
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: CHRONIC KIDNEY-DISEASE ; C-REACTIVE PROTEIN ; MYOCARDIAL-INFARCTION ; HEMODIALYSIS-PATIENTS ; RENAL-DISEASE ; RISK-FACTOR ; CARDIOVASCULAR-DISEASE ; ATHEROSCLEROSIS ; MORTALITY ; PHOSPHATE
英文摘要:

Background: Increased carotid artery intima-media thickness (IMT) predicts future vascular events in the general population. However, the relationship between IMT and chronic kidney disease (CKD) seldom was tested in subjects with early-stage CKD.

Study Design: Cross-sectional study.

Setting & Participants: 1,046 residents in 1 district of Beijing participated in the study.

Outcomes & Measurements: Carotid artery IMT was measured by means of high-resolution B-mode ultrasonography. Estimated glomerular filtration rate (eGFR) was calculated using the modified Modification of Diet in Renal Disease Study equation based on data for Chinese patients with CKD. Albuminuria was evaluated by means of urinary albumin-creatinine ratio on a morning spot urine sample. Results: Compared with subjects with eGFR greater than 90 mL/min/1.73 m(2) (>1.50 mL/s/1.73 m(2)), subjects with eGFR of 60 to 89 mL/min/1.73 m(2) (1.00 to 1.49 mLs/1.73 m(2)) and 30 to 59 mL/min/1.73 m(2) (0.50 to 0.99 mL/s/1.73 m(2)) had higher mean IMT (0.74 +/- 0.27 versus 0.82 +/- 0.30 versus 0.94 +/- 0.38 mm; P < 0.001). IMTs of subjects with albuminuria tended to be higher than the mean value (0.79 +/- 0.29 versus 0.93 +/- 0.38 mm; P < 0.001). eGFR and urinary albumin-creatinine ratio significantly correlated with IMT in univariable analysis, but not after adjusting for traditional cardiovascular disease risk factors.

Limitations: Selection bias and low prevalence of CKD might affect the strength of the study.

Conclusions: In this Chinese population older than 40 years, carotid artery IMT was significantly higher in subjects with early-stage CKD. The greater prevalence of cardiovascular disease risk factors in patients with CKD appeared to account for the higher carotid artery IMT.

语种: 英语
WOS记录号: WOS:000248570300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58189
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Beijing Hypertens League Inst, Beijing, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Div Nephrol, Beijing 100034, Peoples R China
4.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100871, Peoples R China
5.Peking Univ, Hosp 1, Div Cardiol, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, LuXia,Zhao, Feng,Yang, Ying,et al. Association between carotid artery intima-media thickness and early-stage CKD in a Chinese population[J]. AMERICAN JOURNAL OF KIDNEY DISEASES,2007,49(6):786-792.
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