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Proliferation, behavior, and cytokine gene expression of human umbilical vascular endothelial cells in response to different titanium surfaces
An, Na1,2; Schedle, Andreas3; Wieland, Marco4; Andrukhov, Oleh1; Matejka, Michael1; Rausch-Fan, Xiaohui1
关键词Endothelial Cell Titanium Surface Topography Surface Energy Angiogenesis
刊名JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
2010-04-01
DOI10.1002/jbm.a.32539
93A期:1页:364-372
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]PROTEIN-C RECEPTOR ; HUMAN GINGIVAL FIBROBLASTS ; IN-VITRO ; ADHESION MOLECULES ; OXIDATIVE STRESS ; EPITHELIAL-CELLS ; SLA SURFACE ; IMPLANTS ; OSTEOBLASTS ; INFLAMMATION
英文摘要

Success of dental implantation is initially affected by Wound healing of both, hard and soft tissues. Endothelial cells (ECs) are involved as crucial cells in the angiogenesis and inflamination process Of Wound healing. In the present study, proliferation, mobility, cluster formation, and gene expression of angiogenesis-related molecules of unibilical vascular endothelial cells (HUVECs) were investigated On titanium Surfaces with different roughnesses: acid-etched (A), coarse-grit-blasted and, acid-etched (SLA) surfaces, as well as on hydrophilic modified modA and modSLA Surfaces. Cell behaviors were analyzed by proliferation assay and time-lapse microscopy, gene expression was analyzed by real time PCR. Results showed that cell proliferation, mobility, and cluster formation were highest on modA surfaces compared with all other surfaces. HUVECs moved slowly and exhibited seldom cell aggregation on SLA and modSLA surfaces during the whole observing period of 120 h. The gene expressions of the angiogenesis-related factors von Willebrand factor, thrombomodulin, endothelial cell protein C receptor, and adhesion molecules intercellular adhesion molecule-1 and E-selectin were most enhanced on modSLA surfaces. These results suggest that modA Surface is optimal for proliferation and angiogenic behavior of ECs. However, modSLA Surface seems to promote ECs to express angiogenesis-related factor genes, which play essential roles in controlling inflammation and revascularization of wound healing. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 93A: 364-372, 2010

语种英语
WOS记录号WOS:000275131800040
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58192
专题北京大学口腔医学院_牙周科
北京大学口腔医学院_综合治疗二科
作者单位1.Med Univ Vienna, Bernhard Gottlieb Univ Clin Dent, Dept Periodontol, A-1090 Vienna, Austria
2.Peking Univ, Dept Periodontol, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
3.Med Univ Vienna, Bernhard Gottlieb Univ Clin Dent, Cent Res Unit, A-1090 Vienna, Austria
4.Inst Straumann AG, CH-4002 Basel, Switzerland
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An, Na,Schedle, Andreas,Wieland, Marco,et al. Proliferation, behavior, and cytokine gene expression of human umbilical vascular endothelial cells in response to different titanium surfaces[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2010,93A(1):364-372.
APA An, Na,Schedle, Andreas,Wieland, Marco,Andrukhov, Oleh,Matejka, Michael,&Rausch-Fan, Xiaohui.(2010).Proliferation, behavior, and cytokine gene expression of human umbilical vascular endothelial cells in response to different titanium surfaces.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,93A(1),364-372.
MLA An, Na,et al."Proliferation, behavior, and cytokine gene expression of human umbilical vascular endothelial cells in response to different titanium surfaces".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 93A.1(2010):364-372.
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