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学科主题: 口腔医学
题名:
Proliferation, behavior, and cytokine gene expression of human umbilical vascular endothelial cells in response to different titanium surfaces
作者: An, Na1,2; Schedle, Andreas3; Wieland, Marco4; Andrukhov, Oleh1; Matejka, Michael1; Rausch-Fan, Xiaohui1
关键词: endothelial cell ; titanium ; surface topography ; surface energy ; angiogenesis
刊名: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
发表日期: 2010-04-01
DOI: 10.1002/jbm.a.32539
卷: 93A, 期:1, 页:364-372
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: PROTEIN-C RECEPTOR ; HUMAN GINGIVAL FIBROBLASTS ; IN-VITRO ; ADHESION MOLECULES ; OXIDATIVE STRESS ; EPITHELIAL-CELLS ; SLA SURFACE ; IMPLANTS ; OSTEOBLASTS ; INFLAMMATION
英文摘要:

Success of dental implantation is initially affected by Wound healing of both, hard and soft tissues. Endothelial cells (ECs) are involved as crucial cells in the angiogenesis and inflamination process Of Wound healing. In the present study, proliferation, mobility, cluster formation, and gene expression of angiogenesis-related molecules of unibilical vascular endothelial cells (HUVECs) were investigated On titanium Surfaces with different roughnesses: acid-etched (A), coarse-grit-blasted and, acid-etched (SLA) surfaces, as well as on hydrophilic modified modA and modSLA Surfaces. Cell behaviors were analyzed by proliferation assay and time-lapse microscopy, gene expression was analyzed by real time PCR. Results showed that cell proliferation, mobility, and cluster formation were highest on modA surfaces compared with all other surfaces. HUVECs moved slowly and exhibited seldom cell aggregation on SLA and modSLA surfaces during the whole observing period of 120 h. The gene expressions of the angiogenesis-related factors von Willebrand factor, thrombomodulin, endothelial cell protein C receptor, and adhesion molecules intercellular adhesion molecule-1 and E-selectin were most enhanced on modSLA surfaces. These results suggest that modA Surface is optimal for proliferation and angiogenic behavior of ECs. However, modSLA Surface seems to promote ECs to express angiogenesis-related factor genes, which play essential roles in controlling inflammation and revascularization of wound healing. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 93A: 364-372, 2010

语种: 英语
所属项目编号: 423/2005
项目资助者: ITI Foundation
WOS记录号: WOS:000275131800040
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58192
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Med Univ Vienna, Bernhard Gottlieb Univ Clin Dent, Dept Periodontol, A-1090 Vienna, Austria
2.Peking Univ, Dept Periodontol, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
3.Med Univ Vienna, Bernhard Gottlieb Univ Clin Dent, Cent Res Unit, A-1090 Vienna, Austria
4.Inst Straumann AG, CH-4002 Basel, Switzerland

Recommended Citation:
An, Na,Schedle, Andreas,Wieland, Marco,et al. Proliferation, behavior, and cytokine gene expression of human umbilical vascular endothelial cells in response to different titanium surfaces[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2010,93A(1):364-372.
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