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学科主题临床医学
An update on the constitutive relation of ligament tissues with the effects of collagen types
Wan, Chao1,2; Hao, Zhixiu2; Tong, Lingying2; Lin, Jianhao3; Li, Zhichang3; Wen, Shizhu2
关键词Constitutive Relation Ligament Collagen Type Mechanical Properties Human Knee Joint Finite Element Biomechanics
刊名JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
2015-10-01
DOI10.1016/j.jmbbm.2015.06.018
50页:255-267
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]MEDIAL COLLATERAL LIGAMENT ; ANTERIOR CRUCIATE LIGAMENT ; FINITE-ELEMENT-ANALYSIS ; MECHANICAL-PROPERTIES ; IN-VITRO ; TENDON REPAIR ; KNEE-JOINT ; MODEL ; FIBRILS ; RECONSTRUCTION
英文摘要

The musculoskeletal ligament is a kind of multiscale composite material with collagen fibers embedded in a ground matrix. As the major constituent in ligaments to bear external loads, collagens are composed mainly of two collagen contents with different mechanical properties, i.e., types I and III collagen. The constitutive relation of ligaments plays a critical role in the stability and normal function of human joints. However, collagen types have not been distinguished in the previous constitutive relations. In this paper a constitutive relation for ligament tissues was modified based on the previous constitutive relation by considering the effects of collagen types. Both the collagen contents and the mechanical properties of sixteen ligament specimens from four cadaveric human knee joints were measured for determining their material coefficients in the constitutive relation. The mechanical behaviors of ligaments were obtained from both the uniaxial tensile and simple shear tests. A linear regression between joint kinematic results from in vitro and in silico experiments was made to validate the accuracy of this constitutive relation. The high correlation coefficient (R-2=0.93) and significance (P<0.0001) of the regression equation revealed that this modified constitutive relation of ligaments was accurate to be used in studying joint biomechanics. Another finite element analysis with collagen contents changing demonstrated that the effect of variations in collagen ratios on both joint kinematics and ligament biomechanics could be simulated by this constitutive relation. (C) 2015 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号51275267
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000361775000023
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58195
专题北京大学第二临床医学院
作者单位1.Tsinghua Univ, Inst Biomech & Med Engn, Dept Engn Mech, Beijing 100084, Peoples R China
2.Tsinghua Univ, State Key Lab Tribol, Beijing 100084, Peoples R China
3.Peking Univ, Peoples Hosp, Arthrit Clin & Res Ctr, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Wan, Chao,Hao, Zhixiu,Tong, Lingying,et al. An update on the constitutive relation of ligament tissues with the effects of collagen types[J]. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS,2015,50:255-267.
APA Wan, Chao,Hao, Zhixiu,Tong, Lingying,Lin, Jianhao,Li, Zhichang,&Wen, Shizhu.(2015).An update on the constitutive relation of ligament tissues with the effects of collagen types.JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS,50,255-267.
MLA Wan, Chao,et al."An update on the constitutive relation of ligament tissues with the effects of collagen types".JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS 50(2015):255-267.
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