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学科主题: 临床医学
题名:
Both FOXO3a and FOXO1 are involved in the HGF-protective pathway against apoptosis in endothelial cells
作者: Li, Fang1; Qu, Huan2; Cao, Heng-Chang3; Li, Mei-Hong2; Chen, Chen2; Chen, Xiao-Fan1; Yu, Bo4; Yu, Lin5; Zheng, Le-Min6; Zhang, Wei1,4
关键词: Akt ; Apoptosis ; FLIP ; FOXO3a ; FOXO1 ; HUVEC
刊名: CELL BIOLOGY INTERNATIONAL
发表日期: 2015-10-01
DOI: 10.1002/cbin.10486
卷: 39, 期:10, 页:1131-1137
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: HEPATOCYTE GROWTH-FACTOR ; FORKHEAD TRANSCRIPTION FACTOR ; PROTEIN-KINASE-B ; NF-KAPPA-B ; NUCLEAR TRANSLOCATION ; EPITHELIAL-CELLS ; FACTOR AFX ; ACTIVATION ; EXPRESSION ; AKT
英文摘要:

Hepatocyte growth factor (HGF) was identified as an endogenous tissue protective agent against apoptosis in many cell types. The mechanism by which HGF protects primary endothelial cells (ECs) has not yet been completely elucidated. FOXO1 and FOXO3a, two members of the FOXO family, are the most abundant FOXO isoforms in mature endothelial cells. In this study, we aimed to explore whether FOXO1 and FOXO3a play similar roles in HGF-mediated protection against apoptosis in mature endothelial cells. Our result showed that HGF prevented ECs from oxidative-stress induced apoptosis in part by inducing the phosphorylation of FOXO proteins. FOXO1 and FOXO3a are equally important in this process by regulating the expression of Bim, PUMA, FasL, and TRAIL.

语种: 英语
所属项目编号: 2011CB503900 ; 201103019 ; KQCX20120803145850990 ; 81370235 ; 81170101 ; 7122106
项目资助者: "973" National ST Major Project ; Research Grants of Shenzhen Science and Technology Project ; National Natural Science Foundation of China ; Natural Science Foundation of Beijing
WOS记录号: WOS:000362790900006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58203
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Shenzhen Peking Univ, Biomed Res Inst, Hong Kong Univ Sci & Technol, Med Ctr, Shenzhen, Guangdong, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Cardiovascularol, Shenzhen, Guangdong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Emergency Surg, Shenzhen, Guangdong, Peoples R China
4.Peking Univ, Shenzhen Hosp, Dept Dermatol, Shenzhen, Guangdong, Peoples R China
5.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynaecol, Shenzhen, Guangdong, Peoples R China
6.Peking Univ, Hlth Sci Ctr, Dept Cardiovasc Sci, Beijing, Peoples R China

Recommended Citation:
Li, Fang,Qu, Huan,Cao, Heng-Chang,et al. Both FOXO3a and FOXO1 are involved in the HGF-protective pathway against apoptosis in endothelial cells[J]. CELL BIOLOGY INTERNATIONAL,2015,39(10):1131-1137.
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