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学科主题临床医学
Both FOXO3a and FOXO1 are involved in the HGF-protective pathway against apoptosis in endothelial cells
Li, Fang1; Qu, Huan2; Cao, Heng-Chang3; Li, Mei-Hong2; Chen, Chen2; Chen, Xiao-Fan1; Yu, Bo4; Yu, Lin5; Zheng, Le-Min6; Zhang, Wei1,4
关键词Akt Apoptosis FLIP FOXO3a FOXO1 HUVEC
刊名CELL BIOLOGY INTERNATIONAL
2015-10-01
DOI10.1002/cbin.10486
39期:10页:1131-1137
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]HEPATOCYTE GROWTH-FACTOR ; FORKHEAD TRANSCRIPTION FACTOR ; PROTEIN-KINASE-B ; NF-KAPPA-B ; NUCLEAR TRANSLOCATION ; EPITHELIAL-CELLS ; FACTOR AFX ; ACTIVATION ; EXPRESSION ; AKT
英文摘要

Hepatocyte growth factor (HGF) was identified as an endogenous tissue protective agent against apoptosis in many cell types. The mechanism by which HGF protects primary endothelial cells (ECs) has not yet been completely elucidated. FOXO1 and FOXO3a, two members of the FOXO family, are the most abundant FOXO isoforms in mature endothelial cells. In this study, we aimed to explore whether FOXO1 and FOXO3a play similar roles in HGF-mediated protection against apoptosis in mature endothelial cells. Our result showed that HGF prevented ECs from oxidative-stress induced apoptosis in part by inducing the phosphorylation of FOXO proteins. FOXO1 and FOXO3a are equally important in this process by regulating the expression of Bim, PUMA, FasL, and TRAIL.

语种英语
WOS记录号WOS:000362790900006
项目编号2011CB503900 ; 201103019 ; KQCX20120803145850990 ; 81370235 ; 81170101 ; 7122106
资助机构"973" National ST Major Project ; Research Grants of Shenzhen Science and Technology Project ; National Natural Science Foundation of China ; Natural Science Foundation of Beijing
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58203
专题北京大学深圳医院
北京大学医学部管理机构_医学部
北京大学基础医学院
北京大学第三临床医学院_普通外科
作者单位1.Shenzhen Peking Univ, Biomed Res Inst, Hong Kong Univ Sci & Technol, Med Ctr, Shenzhen, Guangdong, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Cardiovascularol, Shenzhen, Guangdong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Emergency Surg, Shenzhen, Guangdong, Peoples R China
4.Peking Univ, Shenzhen Hosp, Dept Dermatol, Shenzhen, Guangdong, Peoples R China
5.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynaecol, Shenzhen, Guangdong, Peoples R China
6.Peking Univ, Hlth Sci Ctr, Dept Cardiovasc Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Li, Fang,Qu, Huan,Cao, Heng-Chang,et al. Both FOXO3a and FOXO1 are involved in the HGF-protective pathway against apoptosis in endothelial cells[J]. CELL BIOLOGY INTERNATIONAL,2015,39(10):1131-1137.
APA Li, Fang.,Qu, Huan.,Cao, Heng-Chang.,Li, Mei-Hong.,Chen, Chen.,...&Zhang, Wei.(2015).Both FOXO3a and FOXO1 are involved in the HGF-protective pathway against apoptosis in endothelial cells.CELL BIOLOGY INTERNATIONAL,39(10),1131-1137.
MLA Li, Fang,et al."Both FOXO3a and FOXO1 are involved in the HGF-protective pathway against apoptosis in endothelial cells".CELL BIOLOGY INTERNATIONAL 39.10(2015):1131-1137.
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