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学科主题临床医学
Subarachnoid Extension of Intracerebral Hemorrhage and 90-Day Outcomes in INTERACT2
Chen, Guofang1,3; Arima, Hisatomi3; Wu, Guojun3,4; Heeley, Emma3; Delcourt, Candice3; Zhang, Peiying2; Rabinstein, Alejandro A.5; Robinson, Thompson6,7; Stapf, Christian8; Huang, Yining9; Song, Lili3,10; Yang, Jie3,11; Wang, Xia3; Li, Qiang3; Chen, Xiaoying3; Chalmers, John3; Anderson, Craig3; INTERACT2 Investigators
关键词assessment outcomes cerebral hemorrhage clinical trial
刊名STROKE
2014
DOI10.1161/STROKEAHA.113.003524
45期:1页:258-260
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Peripheral Vascular Disease
资助者National Health and Medical Research Council of Australia ; National Health and Medical Research Council of Australia
研究领域[WOS]Neurosciences & Neurology ; Cardiovascular System & Cardiology
英文摘要

Background and Purpose The prognostic significance of subarachnoid extension of intracerebral hemorrhage was determined in the INTEnsive blood pressure Reduction in Acute Cerebral hemorrhage Trial (INTERACT2) study.

Methods INTERACT2 was an open randomized controlled trial of early intensive compared with guideline-recommended blood pressure lowering in patients with elevated systolic blood pressure within 6 hours of intracerebral hemorrhage. Independent predictors of death or major disability (scores 3-6 on the modified Rankin Scale) at 90 days were analyzed in logistic regression models.

Results Of 2582 participants, 192 (7%) had subarachnoid extension, which was associated with larger hematoma volumes (P<0.0001) and higher National Institute of Health Stroke Scale score (P<0.0001). Subarachnoid extension predicted death or major disability at 90 days (71% versus 53%; unadjusted odds ratio, 2.25; 95% confidence interval, 1.63-3.10; P<0.0001). The association remained significant after adjusting for age, region, lipid-lowering therapy, systolic blood pressure, glucose, location of hematoma, intraventricular extension, and randomized treatment (odds ratio, 2.17; 95% confidence interval, 1.50-3.14; P<0.0001), but not after further adjustment for baseline hematoma volume (P=0.62).

Conclusions Subarachnoid extension of intracerebral hemorrhage is associated with poor prognosis, which is determined by a larger volume of the underlying intraparenchymal hematoma.

Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT00716079.

语种英语
所属项目编号571281 ; 512402 ; 1004170
资助者National Health and Medical Research Council of Australia ; National Health and Medical Research Council of Australia
WOS记录号WOS:000328823400050
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58204
Collection北京大学第一临床医学院_神经内科
作者单位1.Mayo Clin, Dept Neurol, Rochester, MN USA
2.PLA, Shanghai Hosp 85, Dept Neurol, Shanghai, Peoples R China
3.Hebei Yutian Hosp, Dept Neurol, Tang Shan, Peoples R China
4.Xuzhou Cent Hosp, Dept Neurol, Xuzhou, Jiangsu, Peoples R China
5.Xuzhou Cent Hosp, Dept Cardiol, Xuzhou, Jiangsu, Peoples R China
6.Univ Sydney, George Inst Global Hlth, Sydney, NSW 2050, Australia
7.Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England
8.Univ Leicester, NIHR Biomed Res Unit Cardiovasc Sci, Leicester, Leics, England
9.Univ Paris Diderot, Sorbonne Paris Cite, Dept Neurol, Paris, France
10.Peking Univ, Hosp 1, Dept Neurol, Beijing 100871, Peoples R China
11.Nanjing Med Univ, Nanjing Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China
Recommended Citation
GB/T 7714
Chen, Guofang,Arima, Hisatomi,Wu, Guojun,et al. Subarachnoid Extension of Intracerebral Hemorrhage and 90-Day Outcomes in INTERACT2[J]. STROKE,2014,45(1):258-260.
APA Chen, Guofang.,Arima, Hisatomi.,Wu, Guojun.,Heeley, Emma.,Delcourt, Candice.,...&INTERACT2 Investigators.(2014).Subarachnoid Extension of Intracerebral Hemorrhage and 90-Day Outcomes in INTERACT2.STROKE,45(1),258-260.
MLA Chen, Guofang,et al."Subarachnoid Extension of Intracerebral Hemorrhage and 90-Day Outcomes in INTERACT2".STROKE 45.1(2014):258-260.
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