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学科主题: 精神卫生
题名:
The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects
作者: Li, Jun; Zhang, Xia; Wang, Yufeng; Zhou, Rulun; Zhang, Haobo; Yang, Li; Wang, Bing; Faraone, Stephen V.
关键词: attention-deficit/hyperactivity disorder (ADHD) ; genetic polymorphisms ; TDT ; HTR1D ; serotonin
刊名: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
发表日期: 2006-12-05
DOI: 10.1002/ajmg.b.30364
卷: 141B, 期:8, 页:874-876
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Psychiatry
研究领域[WOS]: Genetics & Heredity ; Psychiatry
关键词[WOS]: DEFICIT/HYPERACTIVITY DISORDER ; POLYMORPHISM ; ADHD ; ASSOCIATION ; SUSCEPTIBILITY ; VARIANTS ; 5-HTTLPR ; BEHAVIOR ; FAMILY ; REGION
英文摘要:

Attention-deficit/hyperactivity disorder (ADHD) is a heritable disease. Serotonin is one of the neurotransmitters involved in the etiology of ADHD. Serotonin-1D receptors are autoreceptors which can regulate the release of serotonin in brain, so the HTR1D gene may be predisposing. The current study genotyped two variants of HTR1D gene in 272 ADHD trios of Chinese ethnicity, that is 1350T > C in the coding region and 1236A > G in 3′-UTR by the use of transmission disequilibrium test (TDT). The A allele of the 1236A > G polymorphism exhibited both a trend toward preferential transmission to ADHD probands (chi(2) = 3.815, P = 0.051) and a significant preferential transmission to probands of ADHDC (chi(2) = 4.198, P = 0.040). Additional polymorphisms in this gene need to be studied further. (c) 2006 Wiley-Liss, Inc.

语种: 英语
WOS记录号: WOS:000242546400007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58206
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ Hosp 6, Inst Mental Hlth, Beijing 100083, Peoples R China
2.SUNY Upstate Med Univ, Genet Res Program, Syracuse, NY USA
3.SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, Syracuse, NY USA

Recommended Citation:
Li, Jun,Zhang, Xia,Wang, Yufeng,et al. The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2006,141B(8):874-876.
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