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The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects
Li, Jun; Zhang, Xia; Wang, Yufeng; Zhou, Rulun; Zhang, Haobo; Yang, Li; Wang, Bing; Faraone, Stephen V.
关键词attention-deficit/hyperactivity disorder (ADHD) genetic polymorphisms TDT HTR1D serotonin
刊名AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
2006-12-05
DOI10.1002/ajmg.b.30364
141B期:8页:874-876
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Psychiatry
研究领域[WOS]Genetics & Heredity ; Psychiatry
关键词[WOS]DEFICIT/HYPERACTIVITY DISORDER ; POLYMORPHISM ; ADHD ; ASSOCIATION ; SUSCEPTIBILITY ; VARIANTS ; 5-HTTLPR ; BEHAVIOR ; FAMILY ; REGION
英文摘要

Attention-deficit/hyperactivity disorder (ADHD) is a heritable disease. Serotonin is one of the neurotransmitters involved in the etiology of ADHD. Serotonin-1D receptors are autoreceptors which can regulate the release of serotonin in brain, so the HTR1D gene may be predisposing. The current study genotyped two variants of HTR1D gene in 272 ADHD trios of Chinese ethnicity, that is 1350T > C in the coding region and 1236A > G in 3′-UTR by the use of transmission disequilibrium test (TDT). The A allele of the 1236A > G polymorphism exhibited both a trend toward preferential transmission to ADHD probands (chi(2) = 3.815, P = 0.051) and a significant preferential transmission to probands of ADHDC (chi(2) = 4.198, P = 0.040). Additional polymorphisms in this gene need to be studied further. (c) 2006 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000242546400007
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58206
专题北京大学精神卫生研究所
作者单位1.Peking Univ Hosp 6, Inst Mental Hlth, Beijing 100083, Peoples R China
2.SUNY Upstate Med Univ, Genet Res Program, Syracuse, NY USA
3.SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, Syracuse, NY USA
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Li, Jun,Zhang, Xia,Wang, Yufeng,et al. The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2006,141B(8):874-876.
APA Li, Jun.,Zhang, Xia.,Wang, Yufeng.,Zhou, Rulun.,Zhang, Haobo.,...&Faraone, Stephen V..(2006).The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,141B(8),874-876.
MLA Li, Jun,et al."The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 141B.8(2006):874-876.
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