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学科主题: 基础医学
题名:
IMPAIRED SYNAPTIC VESICLE RECYCLING CONTRIBUTES TO PRESYNAPTIC DYSFUNCTION IN LIPOPROTEIN LIPASE-DEFICIENT MICE
作者: Liu, X.1,2,3; Zhang, B.4; Yang, H.1,2,3; Wang, H.1,2,3; Liu, Y.1,2,3; Huang, A.5; Liu, T.1,2,3; Tian, X.1,2,3; Tong, Y.1,2,3; Zhou, T.1,2,3; Zhang, T.1,2,3; Xing, G.1,2,3; Xiao, W.6; Guo, X.6; Fan, D.6; Han, X.7; Liu, G.8; Zhou, Z.4; Chui, D.1,2,3,5
关键词: lipoprotein lipase ; presynaptic dysfunction ; synaptic vesicle recycling ; readily releasable pool (RRP) ; synaptic plasticity
刊名: NEUROSCIENCE
发表日期: 2014-11-07
DOI: 10.1016/j.neuroscience.2014.07.080
卷: 280, 期:nov 7, 页:275-281
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: READILY RELEASABLE POOL ; HIPPOCAMPAL SYNAPSES ; MESSENGER-RNA ; LOCALIZATION ; NEURONS ; TISSUES ; ACIDS ; SIZE ; DISEASE ; BRAIN
英文摘要:

Lipoprotein lipase (LPL) is expressed at high levels in hippocampal neurons, although its function is unclear. We previously reported that LPL-deficient mice have learning and memory impairment and fewer synaptic vesicles in hippocampal neurons, but properties of synaptic activity in LPL-deficient neurons remain unexplored. In this study, we found reduced frequency of miniature excitatory postsynaptic currents (mEPSCs) and readily releasable pool (RRP) size in LPL-deficient neurons, which led to presynaptic dysfunction and plasticity impairment without altering postsynaptic activity. We demonstrated that synaptic vesicle recycling, which is known to play an important role in maintaining the RRP size in active synapses, is impaired in LPL-deficient neurons. Moreover, lipid assay revealed deficient docosahexaenoic acid (DHA) and arachidonic acid (AA) in the hippocampus of LPL-deficient mice; exogenous DHA or AA supplement partially restored synaptic vesicle recycling capability. These results suggest that impaired synaptic vesicle recycling results from deficient DHA and AA and contributes to the presynaptic dysfunction and plasticity impairment in LPL-deficient neurons. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2012CB911000 ; 2012CB911004 ; 81171015 ; 81371205 ; 81211140047
项目资助者: National High Technology Research and Development Program of China (973 Program) ; National Natural Science Foundation of China (NSFC) ; NSFC-JSPS
WOS记录号: WOS:000343633100025
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58207
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Inst Mol Med, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Beijing 100191, Peoples R China
3.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
4.Peking Univ, Minist Educ, Dept Neurobiol, Key Lab Neurosci, Beijing 100191, Peoples R China
5.Peking Univ, Minist Publ Hlth, Hlth Sci Ctr, Beijing 100191, Peoples R China
6.Univ Wisconsin, Sch Med, Madison, WI 53706 USA
7.Sanford Burnham Med Res Inst, Diabet & Obes Res Ctr, La Jolla, CA 92037 USA
8.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100191, Peoples R China

Recommended Citation:
Liu, X.,Zhang, B.,Yang, H.,et al. IMPAIRED SYNAPTIC VESICLE RECYCLING CONTRIBUTES TO PRESYNAPTIC DYSFUNCTION IN LIPOPROTEIN LIPASE-DEFICIENT MICE[J]. NEUROSCIENCE,2014,280(nov 7):275-281.
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