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学科主题基础医学
IMPAIRED SYNAPTIC VESICLE RECYCLING CONTRIBUTES TO PRESYNAPTIC DYSFUNCTION IN LIPOPROTEIN LIPASE-DEFICIENT MICE
Liu, X.1,2,3; Zhang, B.4; Yang, H.1,2,3; Wang, H.1,2,3; Liu, Y.1,2,3; Huang, A.5; Liu, T.1,2,3; Tian, X.1,2,3; Tong, Y.1,2,3; Zhou, T.1,2,3; Zhang, T.1,2,3; Xing, G.1,2,3; Xiao, W.6; Guo, X.6; Fan, D.6; Han, X.7; Liu, G.8; Zhou, Z.4; Chui, D.1,2,3,5
关键词lipoprotein lipase presynaptic dysfunction synaptic vesicle recycling readily releasable pool (RRP) synaptic plasticity
刊名NEUROSCIENCE
2014-11-07
DOI10.1016/j.neuroscience.2014.07.080
280期:nov 7页:275-281
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]READILY RELEASABLE POOL ; HIPPOCAMPAL SYNAPSES ; MESSENGER-RNA ; LOCALIZATION ; NEURONS ; TISSUES ; ACIDS ; SIZE ; DISEASE ; BRAIN
英文摘要

Lipoprotein lipase (LPL) is expressed at high levels in hippocampal neurons, although its function is unclear. We previously reported that LPL-deficient mice have learning and memory impairment and fewer synaptic vesicles in hippocampal neurons, but properties of synaptic activity in LPL-deficient neurons remain unexplored. In this study, we found reduced frequency of miniature excitatory postsynaptic currents (mEPSCs) and readily releasable pool (RRP) size in LPL-deficient neurons, which led to presynaptic dysfunction and plasticity impairment without altering postsynaptic activity. We demonstrated that synaptic vesicle recycling, which is known to play an important role in maintaining the RRP size in active synapses, is impaired in LPL-deficient neurons. Moreover, lipid assay revealed deficient docosahexaenoic acid (DHA) and arachidonic acid (AA) in the hippocampus of LPL-deficient mice; exogenous DHA or AA supplement partially restored synaptic vesicle recycling capability. These results suggest that impaired synaptic vesicle recycling results from deficient DHA and AA and contributes to the presynaptic dysfunction and plasticity impairment in LPL-deficient neurons. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000343633100025
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58207
专题北京大学基础医学院_神经生物学系
北京大学公共卫生学院_北京大学儿童青少年卫生研究所
北京大学临床肿瘤学院_流行病学研究室
作者单位1.Peking Univ, Inst Mol Med, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Beijing 100191, Peoples R China
3.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
4.Peking Univ, Minist Educ, Dept Neurobiol, Key Lab Neurosci, Beijing 100191, Peoples R China
5.Peking Univ, Minist Publ Hlth, Hlth Sci Ctr, Beijing 100191, Peoples R China
6.Univ Wisconsin, Sch Med, Madison, WI 53706 USA
7.Sanford Burnham Med Res Inst, Diabet & Obes Res Ctr, La Jolla, CA 92037 USA
8.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100191, Peoples R China
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Liu, X.,Zhang, B.,Yang, H.,et al. IMPAIRED SYNAPTIC VESICLE RECYCLING CONTRIBUTES TO PRESYNAPTIC DYSFUNCTION IN LIPOPROTEIN LIPASE-DEFICIENT MICE[J]. NEUROSCIENCE,2014,280(nov 7):275-281.
APA Liu, X..,Zhang, B..,Yang, H..,Wang, H..,Liu, Y..,...&Chui, D..(2014).IMPAIRED SYNAPTIC VESICLE RECYCLING CONTRIBUTES TO PRESYNAPTIC DYSFUNCTION IN LIPOPROTEIN LIPASE-DEFICIENT MICE.NEUROSCIENCE,280(nov 7),275-281.
MLA Liu, X.,et al."IMPAIRED SYNAPTIC VESICLE RECYCLING CONTRIBUTES TO PRESYNAPTIC DYSFUNCTION IN LIPOPROTEIN LIPASE-DEFICIENT MICE".NEUROSCIENCE 280.nov 7(2014):275-281.
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